الصفحة 1
الصفحة 1
Natural poisons and venoms: Plant toxins : Polyketides, phenylpropanoids and further compounds
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural poisons and venoms : Animal toxins
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural poisons and venom : Plant toxins : Terpenes and steroids
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Mercury Pollution in Minamata
It overviews the poisoning which occurred in the 1950s and 1960s among the residents in Minamata who ate seafood contaminated with methylmercury discharged from the chemical factory, Chisso Corporation. It describes the history, symptoms pathogenesis and research on the causal agent, and discusses the responses of Chisso and the national and local governments to the outbreak, the victims, the compensation and environmental restructuring as well as the court ruling on claims. Based on lecture notes from a university course, it includes students’ suggestions for avoiding a repeat of the tragedy. The issue has not been settled yet, and this analysis of the incident provides useful insights into solutions to the current global mercury pollution problem.
Introduction to toxicology
Charts the evolution of the field of toxicology, from the use of natural toxins by ancient tribes through the developments established by Paracelsus, and progresses through to the current topics in the public interest. For centuries, the study of toxicology has fascinated students. The book begins with basic toxicological principles, including an historical summary, dose-response relationships (NEW chapter), exposure-response relationships (NEW chapter), disposition, and metabolism of xenobiotic toxic substances. Other important new chapters include target organ toxicity, toxicity of carcinogenic agents and new and updated concepts in toxicity testing, and antidotes and treatment of poisonings. In all, nine new or expanded chapters from the third edition are advanced. Current concerns about the effects of therapeutic drugs, carcinogens, industrial toxins, pesticides, and herbicides on human health, animal welfare, and the stability and maintenance of the ecosystem continue to highlight toxicology as an important and growing scientific discipline.
Handbook of Poisonous and Injurious Plants
The Handbook of Poisonous and Injurious Plants, rich in visual images, emergency medical information, botanical descriptions, and scientific references, is the easiest to use and most comprehensive handbook of its kind available today. It will be of great value to physicians, naturalists, horticulturists, parents of small children, pet owners, and all those who interact with plants and the landscapes -- both indoors and outdoors -- in temperate, desert, tropical, and subtropical habitats throughout the year.
Gases and Toxins that Cause Pulmonary Edema
Pulmonary edema is a major health problem in the lung, it is a cardinal feature of congestive heart failure. Pulmonary edema defined as excessive extravascular water in the lungs, is a common and serious clinical problem. Pulmonary edema can be life-threatening, but effective therapy is available to rescue patients from the deleterious consequences of disturbed lung fluid balance, which usually can be identified and, in many instances, corrected. So we like to talk about this common disease because of its importance and its wide spread around the world. Other important causes of pulmonary edema are human exposure to some gases and toxins, the most important of which is chlorine gas, phosgene, mustard gas, heroin, paraquat and ammonia. This research paper will discuss also the procedures that are included, as well as a wider knowledge of these toxins and gases.
Fundamentals of Pharmacognosy and Phytotherapy
Pharmacognosy (the science of biogenic or nature-derived pharmaceuticals and poisons) has been an established basic pharmaceutical science taught in institutions of pharmacy education for over two centuries. Over the past 20 years though it has become increasingly important given the explosion of new drugs, phytomedicines (plant medicines), nutraceuticals and dietary supplements – all of which need to be fully understood, tested and regulated.
Fundamentals of analytical toxicology : Clinical and forensic ; 2nd ed.
An integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques. Focuses on analytical, statistical, and pharmacokinetic principles / Describes basic methodology, including colour tests and immunoassay and enzyme-based assays / Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation / Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides / Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS)
Ethnobotany : A phytochemical perspective
Explores the chemistry behind hundreds of plant medicines, dyes, fibers, flavors, poisons, insect repellants, and many other uses of botanicals. Bridging the gap between ethnobotany and chemistry, this book presents an introduction to botany, ethnobotany, and phytochemistry to clearly join these fields of study and highlight their importance in the discovery of botanical uses in modern industry and research. Part I. Ethnobotany, explores the history of plant exploration, current issues such as conservation and intellectual property rights, and a review of plant anatomy. An extensive section on plant taxonomy highlights particularly influential and economically important plants from across the plant kingdom. Part II. Phytochemistry, provides fundamentals of secondary metabolism, includes line drawings of biosynthetic pathways and chemical structures, and describes traditional and modern methods of plant extraction and analysis. The last section is devoted to the history of native plants and people and case studies on plants that changed the course of human history from five geographical regions: Africa, the Americas, Asia, Europe, and Ocean. Throughout the entire book, vivid color photographs bring science to life, capturing the essence of human botanical knowledge and the beauty of the plant kingdom.
Ecology of Harmful Algae
Harmful algal blooms are one of the consequences of the human impact on aquatic ecosystems, particularly the process of eutrophication. They can cause a variety of deleterious effects, including the poisoning of fish and shellfish, habitat disruptions for many organisms, water discolouration, beach fouling, and even toxic effects for humans. This volume is a comprehensive synthesis of the latest research achievements concerning harmful algae (HA) ecology. International experts provide an in-depth analysis of HA topics including: global distribution, ecology of major HA groups, ecology and physiology of HA, HA and the food web, studying and mitigating HA, the human impact on HA and HA impact on human activity. This volume is an invaluable source of information for researchers in HA ecology as well as for advanced students, lecturers, and environmental managers.
Drugs used in murder and drugs facilitated sexual assaults
Since ancient times, the methods of committing crimes have varied and the methods of killing have varied. The killer has always sought to hide his crime. One of the methods of killing is poisoning the victim, but with the development of science also methods for detecting toxins inside the victim's body have developed. Also, in recent decades, drugs facilitating sexual assault have spread, which aim to make the victim unconscious and paralyze his resistance...
Drugs and Poisons in Humans : A Handbook of Practical Analysis
At the beginning of the book, general topics are addressed, including instructions on h- dling biological materials, measurement of drugs in alternative specimens, and guidance on resolving analytical problems that may occur. T ere are discussions of extraction modalities and detection methodologies and how to select these appropriately based on the physioche- cal characteristics of the drug. Analysis of specif c classes of drugs and relevant metabolites are covered in subsequent chapters.
Drug safety evaluation : Methods and protocols
Focuses on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.
Criminal Poisoning : Investigational Guide for Law Enforcement, Toxicologists, Forensic Scientists, and Attorneys
Investigational Guide for Law Enforcement, Toxicologists, Forensic Scientists, and Attorneys, leading forensic scientist John Trestrail offers a pioneering survey of all that is known about the use of poison as a weapon in murder. Topics range from the use of poisons in history and literature to convicting the poisoner in court, and include a review of the different types of poisons, techniques for crime scene investigation, and the critical essentials of the forensic autopsy. The author updates what is currently known about poisoners in general (psychological profile, types, and statistical analyses) and their victims (who gets poisoned, investigative considerations, and classic symptoms of poisoning).
Marine Natural Products
The search for marine natural products is well-known for colorful pictures of exotic creatures which, after having been found to contain the cure for cancer, disappear into the depths, never to be seen again, or for accounts of scuba-diving chemists in waters alive with poisonous sea snakes - in short, the sort of sensational stuff that even nonchemists find interesting. That sort of thing will not be found in this book.
Layce (Image data poisoning) = لايس (تسميم بيانات الصور )
The ongoing growth of image generative artificial intelligence models was paved with existing drawings and art pieces by great artists both past and present, and while generative models are very useful and helpful, there is the issue of the origin of the datasets trained on, and the morality of usage regarding copyrights and artistic identity. A novel line of defense that helps artists and visual content creators actively protect their pieces emerged, dubbed Data Poisoning and it works by misleading Artificial Intelligence models that attempt to use a Poisoned Image for training, or as a reference, as the Poisoned Image will appear to the human eye identical to the original art piece, while the Artificial Intelligence model will be seeing a remarkably different image, causing generative models to generate false positive results when given a prompt poisoned by the author or when trained on data poisoned by the original owner. This study aims to study image data poisoning methods and technologies, and build an application containing multiple image models, and poisoning models as well, accompanied by a Community for artists to share art and interact with each other.
Carbon monoxide in drug discovery, basics, pharmacology, and therapeutic potential
Carbon monoxide, one of the smallest organic natural molecules, is widely known for its toxicity. Formation of CO via incomplete combustion is a major contributing factor to accidental or intentional CO poisoning, leading to severe health consequences or death. In addition, CO is a by-product of tobacco smoking, and has been associated with some of the harmful effects of smoking. However, less known and probably far more important is the recognition of the essential physiological roles of CO as a signaling molecule in mammals. Against over more than a century of negative connotation, the last few decades have proven that CO possesses a multitude of physiological roles and therapeutic functions including regulation of the immune response, cellular proliferation, and control of cell survival. This concept is supported by the discovery that CO is produced by all cells and more so under conditions of stress. This book comprehensively summarizes key aspects of CO's endogenous roles, therapeutic functions, and challenges that we face in its development as a therapeutic agent. We hope this preface will provide a thread for reading this book and a birds-eye view of the landscape for understanding this field, and more importantly lay out the challenges ahead in understanding the detailed mechanisms of action of CO and in its development as a therapeutic agent.
Botox side effect and natural alternatives
Botox is a drug made from a toxin produced by the bacterium Clostridium botulinum. It's the same toxin that causes a life-threatening type of food poisoning called botulism. Doctors use it in small doses to treat health problems. Botox injections work by weakening or paralyzing certain muscles or by blocking certain nerves. The effects last about three to twelve months, depending on what you are treating...
