الصفحة 1
الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontology Alignment : Bridging the Semantic Gap
Ontology Alignment: Bridging the Semantic Gap introduces novel methods and approaches for semantic integration. In addition to developing new methods for ontology alignment, the author provides extensive explanations of up-to-date case studies. The topic of this book, coupled with the application-focused methodology, will appeal to professionals from a number of different domains.
Ontologies : A Handbook of Principles, Concepts and Applications in Information Systems
The primary objective of ONTOLOGIES: A Handbook of Principles, Concepts and Applications in Information Systems is to mobilize a collective awareness in the research community to the leading and emerging developments in ODIS, and consequently, highlight the enormous potential of ODIS research to both fundamentally transform and create innovative solutions to several problems in various domains. This book is a compilation of 32 leading-edge chapter contributions from some of the top researchers in the community working in various fundamental and applied disciplines related to ODIS. These chapters are organized into four broad themes: Foundations of ODIS, Ontological Engineering, ODIS Architectures, and ODIS Applications.
On the path to AI : Law’s prophecies and the conceptual foundations of the machine learning age
This book explores machine learning and its impact on how we make sense of the world. It does so by bringing together two ‘revolutions’ in a surprising analogy: the revolution of machine learning, which has placed computing on the path to artificial intelligence, and the revolution in thinking about the law that was spurred by Oliver Wendell Holmes Jr in the last two decades of the 19th century.
On Bypass : Advanced Perfusion Techniques
With the introduction of cardiac surgery more than five decades ago and the use of the heart-lung machine for open heart surgical procedures granting the surgeon unlimited time in which to operate inside the heart, a complex task has been given to the Perfusionist. With a pairing of a perfusionist and a surgeon for each chapter, On Bypass: Advanced Perfusion Techniques is an essential collection of techniques and protocols to aid in the difficult and immediate decision making in the operating room. Among the topics covered in this comprehensive text are pediatric perfusion techniques for complex congenital, separation from cardiopumonary bypass, blood flow during cardiopumonary bypass, and minimally invasive perfusion techniques. Also covered is ultrafiltration in cardiac surgery, echocardiography and cardiopulmonary bypass, and advances in long-term pulmonary support.
Omics sudies of medicinal plants
Herbal drugs play a pivotal role in modern medicine and pharmaceutical care; however, only limited biotechnology applications have been seen in medicinal plants. Revolutions in high-throughput approaches emphasize omics approaches, such as genomics, transcriptomics, proteomics, and metabolomics. A volume in the Exploring Medicinal Plants series, this book provides a comprehensive and in-depth analysis of breakthroughs in high-throughput approaches for the research of medicinal plants.
Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting
ompiles the step-by-step investigations made concerning the potential of nanosized emulsions on both drug delivery and drug targeting areas by different group of scientists in various laboratories across the world Inverts the common nano-emulsions coverage trend of focusing on focused on the particulate system itself, instead exploring the way to turn nanosized emulsions as biomedical tool, as well as, treating the in vitro and in vivo aspects after administration Provides an overview of the current state-of-the art regarding the development of tocol emulsions, emulsion adjuvants in immunization research, oxygen-carrying emulsions (called as fluorocarbon emulsion) and emulsions for delivering drugs to nasal and topical (ocular and transdermal) routes
Official Statistics 4.0 : Verified Facts for People in the 21st Century
Explores official statistics and their social function in modern societies. Digitisation and globalisation are creating completely new opportunities and risks, a context in which facts (can) play an enormously important part if they are produced with a quality that makes them credible and purpose-specific. In order for this to actually happen, official statistics must continue to actively pursue the modernisation of their working methods.
Ocular Angiogenesis : Diseases, Mechanisms, and Therapeutics
Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches. Comprehensive and multidisciplinary, Ocular Angiogenesis: Diseases, Mechanisms, and Therapeutics offers a novel view of the clinical features of pathological angiogenesis in the eye, the molecular and environmental switches that govern vessel growth, and the tremendous opportunities for and progress made in the development of new therapeutics.
Ocean Wave Energy : Current Status and Future Prespectives
The authors of this reference provide an updated and global view on ocean wave energy conversion for wave energy developers as well as for students and professors. The book is orientated to the practical solutions that this new industry has found so far and the problems that any device needs to face. It describes the actual principles applied to machines that convert wave power in electricity. Additionally, an historical review, state of the art of modern systems, a full scale prototype experience, and future perspectives are given.
Obstructions in Security-Aware Business Processes : Analysis, Detection, and Handling
This book explores the dilemma-like stalemate between security and regulatory compliance in business processes on the one hand and business continuity and governance on the other. The growing number of regulations, e.g., on information security, data protection, or privacy, implemented in increasingly digitized businesses can have an obstructive effect on the automated execution of business processes. Such security-related obstructions can particularly occur when an access control-based implementation of regulations blocks the execution of business processes. By handling obstructions, security in business processes is supposed to be improved. For this, the book presents a framework that allows the comprehensive analysis, detection, and handling of obstructions in a security-sensitive way. Thereby, methods based on common organizational security policies, process models, and logs are proposed. The Petri net-based modeling and related semantic and language-based research, as well as the analysis of event data and machine learning methods finally lead to the development of algorithms and experiments that can detect and resolve obstructions and are reproducible with the provided software.
Obstetric Anesthesia Handbook
As the field of obstetric anesthesia continues to change rapidly, both in technique and in specific pharmaceutical agents used, it is essential for all practitioners caring for the pregnant patient to be familiar with current anesthetic protocols and general concepts in obstetric anesthesia. The Handbook appeals to a wide audience, as it was written with the practicing anesthesiologists in mind, as well as nurse anesthetists, obstetricians, housestaff, and residents. The Obstetric Anesthesia Handbook supplies expert advice on every facet of anesthesia for childbirth and related obstetric procedures. The text is authoritative, succinct, and highly practical. It is accompanied by over 100 illustrations and tables making the text a convenient reference to the busy practitioner.
Obsessed by a Dream: The Physicist Rolf Widerøe – a Giant in the History of Accelerators
This biography chronicles the life and achievements of the Norwegian engineer and physicist Rolf Widerøe. Readers who meet him in the pages of this book will wonder why he isn't better known.
Object-Oriented Software Engineering Using UML Patterns and Java
Shows students how to use both the principles of software engineering and the practices of various object-oriented tools, processes, and products. Using a step-by-step case study to illustrate the concepts and topics in each chapter, Bruegge and Dutoit emphasize learning object-oriented software engineer through practical experience: students can apply the techniques learned in class by implementing a real-world software project. The third edition addresses new trends, in particular agile project management (Chapter 14 Project Management) and agile methodologies (Chapter 16 Methodologies).
Object Recognition, Attention, and Action
This book provides an excellent introduction to the issues that are involved, with chapters that address the ways in which humans and machines attend to, recognize, and act toward objects in the visual environment.
Object detection with deep learning models : Principles and applications
Discusses recent advances in object detection and recognition using deep learning methods, which have achieved great success in the field of computer vision and image processing. It provides a systematic and methodical overview of the latest developments in deep learning theory and its applications to computer vision, illustrating them using key topics, including object detection, face analysis, 3D object recognition, and image retrieval / A structured overview of deep learning in object detection / A diversified collection of applications of object detection using deep neural networks / Emphasize agriculture and remote sensing domains / Exclusive discussion on moving object detection
Nuucleic acids in medicinal chemistry and chemical biology : Drug development and clinical applications
Delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field
Nutraceuticals in obesity management and control
Provides detailed information on nutraceuticals that can be helpful in the control and management of obesity. It clarifies key aspects of nutraceuticals that include sources, extraction, chemistry, mechanisms of action, pharmacology, bioavailability, safety, and various applications. Beginning with a concise overview of the prevalence of obesity, complications related to obesity, and current treatment regimens, the volume delves into the roles of functional foods and nutraceuticals for the management of body weight and for alleviating obesity comorbidities. It goes on to discuss the effect of some of the most commonly and frequently used naturally occurring nutraceutical substances, along with their mechanisms of action in controlling obesity. The volume looks at the role of nutraceutical fruits as well as the beneficial aspects of carotenoids in fruits and vegetables and explores antioxidant-rich nutraceuticals, the role of vitamins and supplements, the use of green tea, and the potential of pseudocereals and spices in the management of metabolic syndrome.
Nutraceuticals and health care ; 1st ed.
Explores the role of plant-based nutraceuticals as food ingredients and as therapeutic agents for preventing various diseases. The book assesses the role of nutraceuticals in addressing cardiovascular disease, cancer, diabetes, and obesity by highlighting the derivatives, extraction, chemistry, mechanism of action, pharmacology, bioavailability, and safety of specific nutraceuticals. It analyzes twenty one nutraceuticals in a systematic way, providing a welcomed reference for nutrition researchers, nutritionists and dieticians, as well as other scientists studying related areas in food science, technology or agriculture. Students studying related topics will also benefit from this material.
Nutraceuticals : Sources, processing methods, properties, and applications
Explores the impact of nutraceutical compounds on human health and their main pharmacological contributions. Organized into three parts, this book addresses nutraceutical production, applications for disease prevention and treatment, and current trends, especially the role of nutraceuticals in cosmeceutical. Nutraceuticals are a class of products that can help people improve their health, reduce the risk of disease, extend their lives, and control the structure and functioning of their bodies. However, due to multiple hurdles that prevent nutraceuticals from circulating in an active form in the body, their use is associated with diminished therapeutic efficacy. Recognizing this problem, the book explores the root of the nutraceutical delivery system and its codelivery methods with a focus on medicines. With contributions from experienced nutraceutical experts, this book serves as a valuable reference for nutrition researchers, food scientists, pharmacologists, and those who are researching and studying in related areas.
