The Frailty Model
Clustered survival data are encountered in many scientific disciplines including human and veterinary medicine, biology, epidemiology, public health and demography. Frailty models provide a powerful tool to analyse clustered survival data. In contrast to the large number of research publications on frailty models, relatively few statistical software packages contain frailty models.It is demanding for statistical practitioners and graduate students to grasp a good knowledge on frailty models from the existing literature. This book provides an in-depth discussion and explanation of the basics of frailty model methodology for such readers. The discussion includes parametric and semiparametric frailty models and accelerated failure time models. Common techniques to fit frailty models include the EM-algorithm, penalised likelihood techniques, Laplacian integration and Bayesian techniques. More advanced frailty models for hierarchical data are also included.
Sturm-Liouville Theory and its Applications
Undergraduate textbooks on Fourier series which follow a pointwise approach to convergence miss the rich geometric content which comes with treating the subject within the inner product space L2. This book, developed from a course taught to senior undergraduates, provides a unified introduction to Fourier analysis and special functions based on the Sturm-Liouville theory in L2. The basic results of this theory, namely the orthogonality and completeness of its eigenfunctions, are established in Chapter 2; the remaining chapters present examples and applications. The last two chapters, on Fourier and Laplace transformations, while not part of the Sturm-Liouville theory, extend the Fourier series method for representing functions to integral representations.
Principles of signals and systems
Presents basic concepts of signals and systems in a clear manner, based on the author’s 15+ years of teaching the undergraduate course for engineering students. To attain full benefit from the content, readers should have a strong knowledge of calculus and be familiar with integration, differentiation, and summation operations. The book starts with an introduction to signals and systems and continues with coverage of basic signal functions and their manipulations; energy, power, convolution, and systems; Fourier analysis of continuous time signals and digital signals; Laplace transform; and Z transforms. Practical applications are included throughout.
Pharmacocinétique avec Mathematica® = Pharmacokinetics with Mathematica®
This work provides a computer method which allows you to calculate yourself the dispensing of a drug and to visualize the result by varying the ordinary parameters of the medical prescription. It is based on the practical use of Mathematica® as a single or repeated administration regardless of the route of administration in one or two distribution compartments. The traditional differential equations are all replaced by the Laplace transformation which also makes it possible to better differentiate the phenomenon of linearity and non-linearity. It also offers an introduction to population kinetics which, in essence, validates previous calculations and paves the way for modern use of pharmacokinetics for drugs that require greater precision of use. Students of medicine, science and pharmacy will benefit from reading this book, as will drug professionals.
Numerical Methods for Laplace Transform Inversion
Operational methods have been used for over a century to solve many problems—for example, ordinary and partial differential equations. In many problems it is fairly easy to obtain the Laplace transform, but it can be very demanding to determine the inverse Laplace transform that is the solution of the given problem. Sometimes, after some difficult contour integration, we find that a series solution results, but even this may be quite difficult to evaluate in order to get an answer at a particular time value.
Moment Analysis for Subsurface Hydrologic Applications
This book deals with the concept of moments, and how they find application in subsurface hydrologic problems-particularly those dealing with solute transport. This book will be very valuable to researchers who are beginning to learn about moment analysis, and will also be of interest to advanced researchers as well. Both temporal and spatial moments are dealt with in some detail for a wide variety of problems. Several examples using experimental data, both from laboratory columns and field experiments, are provided to give the readers a clear idea about the scope of this method. Apart from conventional uses of moments for solute transport problems, this book contains chapters dealing with use of moments in interval computing, vapour phase transport applications, transfer functions to subsurface tile drains, and construction of breakthrough curves from knowledge of moments.
Metodi Matematici della Fisica = Mathematical Methods of Physics
This text draws its origin from my old notes, prepared for the course of Mathematical Methods of Physics and gradually arranged, refined and updated over the course of many years of teaching. The aim has always been to provide as simple and direct a presentation as possible of the mathematical methods relevant to Physics: Fourier series, Hilbert spaces, linear operators, functions of complex variables, Fourier and Laplace transforms, distributions. In addition to these basic topics, a brief introduction to the first notions of group theory, Lie algebras and symmetries in view of their applications to Physics is presented in the Appendix.
Continuous-Time Systems
The book systematically covers major foundations of the systems theory. First, the quantitative and qualitative methods of systems description are presented along with the stability analysis. The representation of linear time-invariant systems in the time domain is provided using the convolution, ordinarily differential equations (ODEs), and state space. In the frequency domain, these systems are analyzed using the Fourier and Laplace transforms. The linear time-varying systems are represented using the general convolution, ODEs, and state space. The nonlinear time-invariant systems are described employing the Taylor and Volterra series expansions, ODEs, state space, and approximate methods such as averaging, equivalent linearization, and describing function. Finally, the representation of nonlinear time-varying systems is given using the Taylor and Volterra series, ODEs, modulation functions method, and state space modelling.
Mathematical methods for engineers and scientists 2 : Vector analysis, ordinary differential equations and laplace transforms
Pedagogical insights gained through 30 years of teaching applied mathematics led the author to write this set of student-oriented books. Topics such as complex analysis, matrix theory, vector and tensor analysis, Fourier analysis, integral transforms, ordinary and partial differential equations are presented in a discursive style that is readable and easy to follow.








