الصفحة 1
الصفحة 1
Oncology : An Evidence-Based Approach
Reflect the principles and current practice of oncology with contributors from the fields of medical, surgical, and radiation oncology. The textbook will incorporate an evidence-based approach, enabling the reader to make decisions on the basis of concrete data. Sections on solid tumors, hematologic malignancies and the practice of oncology address the natural history and therapy for the full spectrum of neoplastic diseases in the adult. Further sections present fundamentals of supportive care of the cancer patient, the management of oncologic emergencies and acute toxicities of therapy, as well as care of metastatic disease and the terminally-ill patient. Breaking new ground, the textbook features thoughtful, in-depth sections on cancer prevention and control, cancer surviorship, the economics of cancer care, and cancer informatics. Cancer imaging is covered with an organ system-based approach, with an additional chapter on the especially intriguing potential of PET. Furthermore, a comprehensive section on translational basic science reviews the fundamentals of molecular biology, the cell cycle and signal transduction, carcinogenesis, cancer genetics, the biology of invations and metastasis, and tumor immunology.
Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
On the move to meaningful internet systems 2007 : CoopIS, DOA, ODBASE, GADA, and IS ; OTM Confederated International Conferences, CoopIS, DOA, ODBASE, GADA, and IS 2007, Vilamoura, Portugal, November 25-30, 2007, Proceedings, Part II
This two-volume set LNCS 4803/4804 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2007), Distributed Objects and Applications (DOA 2007), Ontologies, Databases and Applications of Semantics (ODBASE 2007), Grid computing, high performance and Distributed Applications (GADA 2007), and Information Security (IS 2007) held as OTM 2007 in Vilamoura, Portugal, in November 2007.
On the Move to Meaningful Internet Systems : OTM 2008 ; OTM 2008 Confederated International Conferences, CoopIS, DOA, GADA, IS, and ODBASE 2008, Monterrey, Mexico, November 9-14, 2008, Proceedings, Part II
This two-volume set LNCS 5331/5332 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2008), Distributed Objects and Applications (DOA 2008), Grid computing, high performAnce and Distributed Applications (GADA 2008), Information Security (IS 2008), and Ontologies, Databases and Applications of Semantics (ODBASE 2008), held as OTM 2008 in Monterrey, Mexico, in November 2008.
Oilseeds
Genome Mapping and Molecular Breeding in Plants presents the current status of the elucidation and improvement of plant genomes of economic interest. The focus is on genetic and physical mapping, positioning, cloning, monitoring of desirable genes by molecular breeding and the most recent advances in genomics. The series comprises seven volumes: Cereals and Millets; Oilseeds; Pulses, Sugar and Tuber Crops; Fruits and Nuts; Vegetables; Technical Crops; and Forest Trees.
Office Andrology
The investigation and management of male infertility can be a formidable diagnostic challenge to family physicians, urologists, and reproductive specialists alike. In Office Andrology, noted clinical physicians and scientists have joined forces to create a comprehensive resource guide to current diagnostic and treatment options for a broad spectrum of clinical issues relevant to male infertility disorders. Topics covered range from basic sperm biology and male reproductive endocrinology, to immunology, specialized sperm testing, and the genetic background to male infertility. Although emphasis is on the investigation, diagnostic testing, and management of the infertile male, controversial medical and surgical treatment options are also fully discussed. For the reproductive specialist, the text thoughtfully reviews such timely issues as gender selection, human immunodeficiency virus-discordance couples, and posthumous reproduction. Other topics of interest include laboratory accreditation, vasectomy reversal, ethical and legal considerations of donor insemination, optimizing success in a donor insemination program, and strategic therapies for ejaculatory disorders and erectile dysfunction in infertile men.
Obesity and Cancer
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development.
Nutrigenomics and nutraceuticals
Provides an authoritative and comprehensive overview of the field of nutraceuticals and genomics—also called nutrigenomics, a rapidly growing field. It discusses both nutrigenomic and nutrigenetic techniques to investigate the nutritional basis of several health disorders because scientists have found that diet can affect gene expression. The book covers the nutrigenomic tools for the prevention of disease conditions such as cancer, viral infection, microbial infection, COVID-19, HIV/AIDS, tuberculosis, hypertension, neurodegenerative disease, obesity, baldness, and anemia. Some nutrigenomic tools that can also be used for brain health, weight loss, human nutrition, skin care, and maintaining health during pregnancy are also explored.
Nuclear Import and Export in Plants and Animals
Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA. A chapter on research methods to study nuclear transport concludes the book.
Novel mouse model for future autism research
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures in the first 3 years of life. It is not a single disorder, and it is broadly considered to be a multi-factorial disorder resulting from genetic and non-genetic risk factors and their interaction. Genetic studies of ASD have identified mutations that interfere with typical neurodevelopment in utero through childhood. These complexes of genes have been involved in synaptogenesis and axon motility. Recent developments in neuroimaging studies have provided many important insights into the pathological changes that occur in the brain of patients with ASD in vivo. Especially, the role of amygdala, a major component of the limbic system and the affective loop of the cortico-striatothalamo-cortical circuit, in cognition and ASD has been proved in numerous neuropathological and neuroimaging studies.
Novel Biotechnologies for Biocontrol Agent Enhancement and Management
This multidisciplinary group, having backgrounds in the diff- ent aspects of biotechnologies (transgenic enhancement, molecular biology, formulation, genetics, risk assessment, new technology, biochemistry, and physiology), presented highly advanced lectures during the 10-day-ASI, in order to allow students to improve their capability to enhance and manage - ological control agents. This approach will allow ASI attendees to bring new ideas, new approaches, or new methodologies coming from different ?elds of application to their own ?eld of expertise.
Non-viral Gene Therapy: Gene Design and Delivery
The development of gene medicine based on the concept of molecular therapy has opened new medical horizons. Among the many techniques in gene medicine, gene design and delivery are especially significant in clinical applications. This book presents state-of-the-art information on non-viral gene-delivery techniques, covering a broad spectrum of disciplines that include chemistry, molecular biology, cell biology, and pharmacokinetics
Nitrogen-fixing Leguminous Symbioses
This book is the self-contained final volume of a comprehensive seven-volume series covering the basic and applied science relating to nitrogen fixation. It addresses the most important nitrogen-fixing symbiosis of all – that between legumes and their root-nodule bacteria – and therefore deals with the properties and behaviour of both macro- and micro-symbiont.
Nitrogen-fixing Actinorhizal Symbioses
This book is the self-contained sixth volume of a comprehensive series on nitrogen fixation. It presents the state-of-the-art in regards to actinorhizal symbioses. Like legumes, actinorhizal plants form root nodules that host nitrogen-fixing soil bacteria. However, because the macrosymbionts are, with one exception, woody plants rather than crop plants, actinorhizal symbioses are less well-known than legume symbioses to which they are phylogenetically related. Actinorhizal plants come from eight different families. This volume includes chapters that deal with all these aspects of the symbiosis and both symbionts plus their ecological role and use. Other chapters tackle the global distribution of different actinorhizal plants and their microsymbionts and how this impacts the question of co-evolution of the micro- and macrosymbionts as well as comparing the actinorhizal and leguminous symbioses.
Nitrogen Fixation in Agriculture, Forestry, Ecology, and the Environment
Sustainability has a major part to play in the global challenge of continued development of regions, countries, and continents all around the World and biological nitrogen fixation has a key role in this process. This volume begins with chapters specifically addressing crops of major global importance, such as soybeans, rice, and sugar cane. It continues with a second important focus, agroforestry, and describes the use and promise of both legume trees with their rhizobial symbionts and other nitrogen-fixing trees with their actinorhizal colonization. An over-arching theme of all chapters is the interaction of the plants and trees with microbes and this theme allows other aspects of soil microbiology, such as interactions with arbuscular mycorrhizal fungi and the impact of soil-stress factors on biological nitrogen fixation, to be addressed. Furthermore, a link to basic science occurs through the inclusion of chapters describing the biogeochemically important nitrogen cycle and its key relationships among nitrogen fixation, nitrification, and denitrification. The volume then provides an up-to-date view of the production of microbial inocula, especially those for legume crops.
New trends in computational vision and bio-inspired computing : Selected works presented at the ICCVBIC 2018, Coimbatore, India
Gathers selected, peer-reviewed original contributions presented at the International Conference on Computational Vision and Bio-inspired Computing (ICCVBIC) conference which was held in Coimbatore, India, on November 29-30, 2018. The works included here offer a rich and diverse sampling of recent developments in the fields of Computational Vision, Fuzzy, Image Processing and Bio-inspired Computing. The topics covered include computer vision; cryptography and digital privacy; machine learning and artificial neural networks; genetic algorithms and computational intelligence; the Internet of Things; and biometric systems, to name but a few. The applications discussed range from security, healthcare and epidemic control to urban computing, agriculture and robotics.
New Trends in Applied Artificial Intelligence ; 20th International Conference on Industrial, Engineering, and Other Applications of Applied Intelligent Systems. IEA/AIE 2007, Kyoto, Japan, June 26-29, 2007, Proceedings
The 20 International Conference on Industrial, Engineering and Other Applications of Applied Intelligent S- tems (IEA/AIE-2007) held in Kyoto, Japan presented such work performed by many scientists worldwide. The previous IEA/AIE conference held in Japan was the Ninth International Conference on Industrial and Engineering Applications of Arti?cial Intelligence and Expert systems (IEA/AIE-1996) in Fukuoka in 1996.
New Frontiers in Applied Artificial Intelligence ; 21st International Conference on Industrial, Engineering and Other Applications of Applied Intelligent Systems, IEA/AIE 2008 Wrocław, Poland, June 18-20, 2008 Proceedings
The 75 revised full papers presented were carefully reviewed and selected from 302 submissions. The papers are organized in topical sections on computer vision, fuzzy system applications, robot and manufacturing, data mining and KDS, neural networks, machine learning, natural language processing, internet application and education, heuristic search, application systems, agent-based system, evolutionary and genetic algorithms, knowledge management, and other applications. The book concludes with 15 contributions from the following special sessions: knowledge driven manufacturing systems, joint session on adaptive networked systems and fuzzy knowledge bases, and software agents and multi-agent systems.
New Computational Methods in Power System Reliability
Power system reliability is in the focus of intensive study due to its critical role in providing energy supply to the modern society. This book is not aimed at providing the overview of the state of the art in power system reliability. On the contrary, it describes application of some new specific techniques: universal generating function method and its combination with Monte Carlo simulation and with random processes methods, Semi-Markov and Markov reward models and genetic algorithm.
New Challenges in Applied Intelligence Technologies
This book includes 37 chapters which discuss examples of applications of intelligence technologies to five fields, reflecting main streams of practical and scientific interest of computer related community: agent and multi-agent systems; personal assistants and recom mender systems; knowledge modeling and processing; optimization and combinatorial problems; computer and telecommunication systems.
