الصفحة 1
الصفحة 1
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Biopharmaceutics applications in drug development

This book introduces fundamental concepts, methods, and advances in the areas of dissolution, absorption, and permeability and their key applications in dosage form performance. Case studies are used to discuss the applications of biopharmaceutic strategies in the development of successful drugs, with a specific focus on the applications of biopharmaceutic strategies in the development of successful drugs. The book presents an integrated view in linking pharmaceutic to the biological consequences of drug products and leverages those for decision making in drug development.

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Kinetics of Water-Rock Interaction

Systems at the surface of the Earth are continually responding to energy inputs derived from solar radiation or from the radiogenic heat in the interior. These energy inputs drive plate movements and erosion, exposing metastable mineral phases at the Earth’s surface. In addition, these energy fluxes are harvested and transformed by living organisms. As long as these processes persist, chemical disequilibrium at the Earth’s surface will be perpetuated. Chemical disequilibrium is also driven by human activities related to production of food, extraction of water and energy resources, and burial of wastes. To understand how the surface of the Earth will change over time, we must understand the rates at which reactions occur and the chemical feedbacks that relate these reactions across extreme temporal and spatial scales. This book addresses fundamental and applied questions concerning the rates of water-rock interactions driven by tectonic, climatic, and anthropogenic forcings.

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Biogeochemistry of Trace Elements in Arid Environments

Global warming has worsened the water resource crisis in many arid zones worldwide, from Africa to Asia, affecting millions of people and putting them at risk of hunger. Effective management of arid zone resources, including understanding the risks of toxic trace and heavy elements to humans, coupled with the need to produce more food to feed the world’s growing population, has thus become increasingly important. This very timely book, the only one of its kind on the market, fills the gap of our knowledge of trace elements in these regions. This book begins by introducing the nature and properties of arid zone soil, followed by an updated overview and comprehensive coverage of the major aspects of the trace elements and heavy metals of most concern in the world’s arid and semi-arid soils. These aspects include: - content and distribution - solution chemistry - solid-phase chemistry - selective sequential dissolution techniques - transfer fluxes - bioavailability - pollution and remediation In order to illustrate the themes, a comprehensive and focused case study on transfer fluxes of trace elements in Israeli arid soils is presented. Finally it closes with the global perspectives on anthropogenic interferences in the natural trace elements’ distribution.

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25 Years of Transformations of Higher Education Systems in Post-Soviet Countries : Reform and Continuity

A result of the first ever study of the transformations of the higher education institutional landscape in fifteen former USSR countries after the dissolution of the Soviet Union in 1991. It explores how the single Soviet model that developed across the vast and diverse territory of the Soviet Union over several decades has evolved into fifteen unique national systems, systems that have responded to national and global developments while still bearing some traces of the past. The book is distinctive as it presents a comprehensive analysis of the reforms and transformations in the region in the last 25 years; and it focuses on institutional landscape through the evolution of the institutional types established and developed in Pre-Soviet, Soviet and Post-Soviet time. It also embraces all fifteen countries of the former USSR, and provides a comparative analysis of transformations of institutional landscape across Post-Soviet systems.

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