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Open and Closed Innovation : Different Cultures for Different Strategies
Open Innovation is a phenomenon in both research and management practice. Since radical innovation or new business development often require external technologies or ways of commercialization, many firms have shifted from a Closed to an Open Innovation model. However, firms often face difficulties during the implementation. While the implementation effort usually focuses on external ideas and technologies as well as the processes to identify them, cultural challenges are neglected. Philipp Herzog develops a theoretical framework arguing that Open Innovation and Closed Innovation cultures need to be different (e.g. regarding the not-invented-here (NIH) syndrome). Based on a multi-respondent survey among 120 R&D employees from three business units of a leading chemical firm, he provides empirical evidence for many of the hypothesized differences in innovation culture.
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontologies for Urban Development
Action C21 of the European programme for Cooperation in the field of Scientific and Technical Research (COST—http://www.cost.esf.org/) is dedicated to investigating urban ontologies for an improved communication in urban civil engineering projects. The Action, known informally as "Towntology", brings together a large and heterogeneous grouping from across Europe, whose interests range from construction to urban tourism and from transport infrastructure to resource visualisation. On 6-7 November 2006, in Geneva, the Action convened a successful workshop to address emerging issues in the field. This volume presents the contributions to that workshop, in many cases revised afterwards to capture some of the outcomes of discussion.
Ontologies for Software Engineering and Software Technology
The editors structured the contributions into three parts: first, a detailed introduction into the use of ontologies in software engineering and software technology in general; second, the use of ontologies to conceptualize different process-related domains such as software maintenance, software measurement, or SWEBOK, initiated by IEEE; third, the use of ontologies as artifacts in several software processes, like, for example, in OMG’s MOF or MDA.
Ontologies : A Handbook of Principles, Concepts and Applications in Information Systems
The primary objective of ONTOLOGIES: A Handbook of Principles, Concepts and Applications in Information Systems is to mobilize a collective awareness in the research community to the leading and emerging developments in ODIS, and consequently, highlight the enormous potential of ODIS research to both fundamentally transform and create innovative solutions to several problems in various domains. This book is a compilation of 32 leading-edge chapter contributions from some of the top researchers in the community working in various fundamental and applied disciplines related to ODIS. These chapters are organized into four broad themes: Foundations of ODIS, Ontological Engineering, ODIS Architectures, and ODIS Applications.
Online Storage Systems and Transportation Problems with Applications : Optimization Models and Mathematical Solutions
This books covers the analysis and development of online algorithms involving exact optimization and heuristic techniques, and their application to solve two real life problems. The first problem is concerned with a complex technical system: a special carousel based high-speed storage system - Rotastore. It is shown that this logistic problem leads to an NP-hard Batch PreSorting problem which is not easy to solve optimally in offline situations. The second problem originates in the health sector and leads to a vehicle routing problem. Reasonable solutions for the offline case covering a whole day with a few hundred orders are constructed with a heuristic approach, as well as by simulated annealing. Optimal solutions for typical online instances are computed by an efficient column enumeration approach leading to a set partitioning problem and a set of routing-scheduling subproblems. The latter are solved exactly with a branch-and-bound method which prunes nodes if they are value-dominated by previous found solutions or if they are infeasible with respect to the capacity or temporal constraints.
One hundred years of social protection : The changing social question in Brazil, India, China, and South Africa
As the first in-depth study of the ideational foundations of social protection policies and programmes in these four countries, the contributions demonstrate that the social question was articulated in an increasingly inclusive way.
One Hundred Years of Intuitionism (1907-2007) : The Cerisy Conference
With logicism and formalism, intuitionism is one of the main foundations for mathematics proposed in the twentieth century; and since the seventies, notably its views on logic have become important also outside foundational studies, with the development of theoretical computer science. The aim of the book is threefold: to review and complete the historical account of intuitionism; to present recent philosophical work on intuitionism; and to give examples of new technical advances and applications of intuitionism.
One Hundred Years of Chemical Warfare : Research, Deployment, Consequences
On April 22, 1915, the German military released 150 tons of chlorine gas at Ypres, Belgium. Carried by a long-awaited wind, the chlorine cloud passed within a few minutes through the British and French trenches, leaving behind at least 1,000 dead and 4,000 injured. This chemical attack, which amounted to the first use of a weapon of mass destruction, marks a turning point in world history. The preparation as well as the execution of the gas attack was orchestrated by Fritz Haber, the director of the Kaiser Wilhelm Institute for Physical Chemistry and Electrochemistry in Berlin-Dahlem. During World War I, Haber transformed his research institute into a center for the development of chemical weapons (and of the means of protection against them).
On the Way to the Web : The Secret History of the Internet and its Founders
On the Way to the Web: The Secret History of the Internet and Its Founders is an absorbing chronicle of the inventive, individualistic, and often cantankerous individuals who set the Internet free. Michael A. Banks describes how the online population created a new culture and turned a new frontier into their vision of the future. This book will introduce you to the innovators who laid the foundation for the Internet and the World Wide Web, the man who invented online chat, and the people who invented the products all of us use online every day. Learn where, when, how and why the Internet came into being, and exactly what hundreds of thousands of people were doing online before the Web. See who was behind it all, and what inspired them.
On the history of the idea of law
On the History of the Idea of Law is the first book ever to trace the development of the philosophical theory of law from its first appearance in Plato's writings to today. Professor Letwin finds important and positive insights and tensions in the theories of Plato
On the construction of engineering handbooks : With an Illustration from the railway safety domain
This book is the first to reflect upon the question of how to construct a desktop handbook. It is demonstrated how concept analysis can be used for identifying settled knowledge as the key ingredient by utilizing the assembled data for classification; a presentation scheme for handbook articles is developed and demonstrated to be suitable. The sketched approach is then illustrated by an example from the railway safety domain. Finally, the limitations of the presented methods are discussed.
On color
Investigates color from numerous perspectives: literary, historical, cultural, anthropological, philosophical, art historical, political, and scientific. In ten lively and wide-ranging chapters, each devoted to a different color, they examine the various ways colors have shaped and continue to shape our social and moral imaginations. Each individual color becomes the focal point for a consideration of one of the extraordinary ways in which color appears and matters in our lives. Beautifully produced in full color, this book is a remarkably smart, entertaining, and fascinating guide to this elusive topic.
Omega-3 fatty acids : Keys to nutritional health
Argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health.
Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting
ompiles the step-by-step investigations made concerning the potential of nanosized emulsions on both drug delivery and drug targeting areas by different group of scientists in various laboratories across the world Inverts the common nano-emulsions coverage trend of focusing on focused on the particulate system itself, instead exploring the way to turn nanosized emulsions as biomedical tool, as well as, treating the in vitro and in vivo aspects after administration Provides an overview of the current state-of-the art regarding the development of tocol emulsions, emulsion adjuvants in immunization research, oxygen-carrying emulsions (called as fluorocarbon emulsion) and emulsions for delivering drugs to nasal and topical (ocular and transdermal) routes
Oil Spill Response : A Global Perspective
This book provides a timely international perspective on applied research and development, technology transfer, and “lessons learned” from field trials and actual case studies associated with recent spill events. This book provides a synopsis as to the methods currently employed to deals with spills and an insight on future technologies under development.
Oil and Security : A World Beyond Petroleum
This book examines the economic impact of changes in the global demand and supply for fossil fuels both on the major producers in Middle Eastern countries around the Persian Gulf, other producers, as well as the world at large. The economic, social and political life of most countries is not only intimately linked to and influenced by the energy market but also affected by historical developments. Among other issues, it shows how the economic, social and political development of societies in Arabia, the peoples of the Arab Peninsula are influenced by their historic and cultural environment, and what the future may bring to this region when their principal economic assets, petroleum and gas, start to lose markets as alternative sources of fossil fuel, alternative, and renewable energy supply the bulk of global energy needs. It also describes how changing fossil fuel costs, access, security of supply, and environmental impacts may affect future economic, social, and political developments as well as technological advances and changes in priorities.
Offshore Wind Energy : Research on Environmental Impacts
The accompanying ecological research for using wind energy in the German North and Baltic Seas has brought out a variety of results concerning possible effects on the marine environment. This book provides an overview of the state of the accompanying ecological research in Germany. It shows the relevance of the new results of the research projects for the planning and permission process for offshore wind energy farms.
Offshore Risk Assessment : Principles, Modelling and Applications of QRA Studies
This updated and expanded second edition has been informed by a major R&D programme on offshore risk assessment in Norway (2002–2006), and reflects the trend of expanded use of floating production installations. It starts with a thorough discussion of risk metrics and risk analysis methodology with subsequent chapters devoted to analytical approaches to escalation, escape, evacuation and rescue analysis of safety and emergency systems. Separate chapters analyse the main hazards of offshore structures: fire, explosion, collision and falling objects. Risk mitigation and control are discussed, as well as an illustration of how the results from quantitative risk assessment studies should be presented. The second edition has a stronger focus on the use of risk assessment techniques in the operation of offshore installations. Also decommissioning of installations is covered.
Official Statistics 4.0 : Verified Facts for People in the 21st Century
Explores official statistics and their social function in modern societies. Digitisation and globalisation are creating completely new opportunities and risks, a context in which facts (can) play an enormously important part if they are produced with a quality that makes them credible and purpose-specific. In order for this to actually happen, official statistics must continue to actively pursue the modernisation of their working methods.
