الصفحة 1
الصفحة 1
Tobacco Control Policy in the Netherlands : Between Economy, Public Health, and Ideology
Governments have known since the 1960s that smoking results in irreversible health damage. This open access book examines why governments have done so little to combat this when they have been aware of the problem and its solutions for decades. What are the strategies and decisions that make a difference, given that policy environments are often not conducive to change? Taking the Netherlands as an example, this book helps to understand the complex policy process at the national level and why it so often appears irrational to us. It is the most sophisticated analysis of tobacco control policy to date, applying insights from political sciences to the field of tobacco control.
The Histone Code and Beyond : New Approaches to Cancer Therapy
Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
The Evolution of the US Airline Industry : Theory, Strategy and Policy
For over three decades the airline industry has continued to maintain a high profile in the public mind and in public policy interest. This high profile is probably not surprising. There does seem to be something inherently newsworthy about airplanes and the people and companies that fly them. The industry was one of the first major industries in the United States to undergo deregulation, in 1978. It thereby transitioned from a closely regulated sector (the former Civil Aeronautics Board tightly controlled everyt thing from prices to routes to entry) to one that is largely market oriented. The incumbent carriers transformed themselves from the point-to-point operators that the CAB had required to the hub-and-spokes structures that took better advantage of their network characteristics. This legacy, when combined with the high-fare end of the yield-management pricing structure, has made them vulnerable to entry by new carriers with lower cost structures.
Telecommunications Planning : Innovations in Pricing, Network Design and Management
Focuses on the latest methodological developments in three key areas---pricing of telecommunications services, network design, and resource allocation. These three elements are most relevant to current telecommunications planning. The first five chapters cover global deregulation of the telecommunications industry, effective pricing and revenue management, as well as an understanding of competitive pressures are key factors that will improve revenue in telecommunications companies. These chapters present some novel ideas related to pricing (including auction-based pricing of network bandwidth) and modeling competition in the industry. The next seven chapters outline what successful telecommunications companies of the future will need to do in order to minimize their costs and still meet customer expectations. In this context the optimal design/provisioning of telecommunication networks plays an important role. These chapters focus on network design for a wide range of technologies including SONET, SDH, WDM, and MPLS. They include the latest research developments related to the modeling and solving of network design problems. The final six chapters provide insightful solutions to several resource allocation problems. Day-to-day management/control of telecommunications networks is dependant upon the optimal allocation of resources.
Risk-Averse Capacity Control in Revenue Management
“If necessity is the mother of invention, then deregulation is the father, and r- enue management (also known as yield management) is the couple’s golden child – at least as far as operations research is concerned.” (Horner, 2000, p. 47) Deregulation had a signi?cant impact on the U.S. airline industry in the late 1970s. Charter and low-cost airlines such as People Express and Southwest wereabletoo?erseatsatafractionofthepricechargedbyestablishedcarriers like Pan Am and American Airlines. Due to their di?erent cost structure, it seemed to be impossible for the big carriers to o?er tickets at the same low price. Yet they had to ?nd a way to compete. Robert L. Crandall from American Airlines is widely credited with the - lution to the problem:yield management – today calledrevenue management, since it maximizes revenue earned on a ?ight rather than yield (revenue per passenger mile).
Business freedoms and fundamental rights in European Union law
The recognition of the freedom to conduct a business as a fundamental right within European Union law has reignited debate as to the proper place of competing economic freedoms and fundamental social rights within the European Union legal order. In particular, the Court of Justice of the European Union has relied on freedom of contract as a component of the freedom to conduct a business in order to undermine the protection of competing employment rights.
Obtaining the best from Regulation and Competition
Deregulation has introduced competition into traditionally monopolistic markets, particularly telecommunications and electric utilities. This book brings together ten essays that were presented at the Center for Research in Regulated Industries at Rutgers University and funded by several regulated companies. The authors, who include young scholars as well as established and highly regarded consultants and researchers, address some of the major issues now facing network industries and regulators - deregulation, competition, stranded assets, diversification, pricing, and mergers and acquisitions.
Molecular Pathology of Gynecologic Cancer
This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients.
International Corporate Finance : Value Creation with Currency Derivatives in Global Capital Markets
International Corporate Finance offers thorough coverage of the international monetary system, international financing, foreign exchange risk management and cross-border valuation. Additionally, the book offers keen insight on how disintermediation, deregulation and securitization are re-shaping global capital markets.
Inhibitors of protein kinases and protein phosphates
The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases.
Handbook Utility Management
As the deregulation of European utility markets has progressed, the dynamics of and the competitive pressure in the utility industries have steadily intensified over recent years. These changes in the regulatory framework have caused a shift in the direction of an integrated market environment, resulting in new challenges for the management of power and gas companies and a substantial need for strategic reorientation. The Handbook Utility Management is concerned with these changes and challenges in the utility industries and emerging managerial issues of high practical relevance. Inclusion of the latest insights into the economic, technological, and legal drivers of the diverse value chain activities makes the Handbook a valuable asset for both professionals and researchers.
Genome instability in cancer development
Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes.
Economic Analysis of Information System Investment in Banking Industry
Explains in reahty, examines theoretically, and analyzes statistically information system investment in the banking industry with regard to the process of the information technology revolution. This kind of comprehensive research on the banking industry is the first in the world. It could be seen as an application study for Japanese financial deregulation after 1997. However, our project, the Workshop of Information System Investment, is a theoretical research venture, consisting originally, when it began in 1994, of economists and computer scientists. It aimed to measure the effect of com puter hardware and software on the modern economy, based on the microdata of each firm, and to extend the frontiers of economic science. It was, coin- dentally, the time when this project began full-scale operation, in July 1997, that the voluntary closure of Yamaichi Securities was decided. The failure of the Hokkaido Takushoku Bank was disclosed in November of the same year, and the breakdown, temporary nationalization, buying out, and mergers of several banks succeeded one another. Our research therefore suddenly got into the social spotlight on the application stage. Part I is the first history and strategic guidelines of information systems in the banking industry. Part II summarizes the economic analyses of informa tion system investment in the United States, Europe, and Japan. These parts are foundations for the statistical analyses in Part III.
Drug Delivery Systems for Metabolic Disorders
Covers recent developments in advanced drug delivery systems in various metabolic disorders, including disturbances in protein, lipid, carbohydrate and hormone metabolism and lysosomal and mitochondrial disorders. It provides a brief introduction to metabolic disorders, along with a focus on the current landscape and trends in understanding disease pathology using different in vitro and in vivo models required for clinical applications and developments of new therapeutics.
Competition Policies in Emerging Economies : Lessons and Challenges from Central America and Mexico
Do small developing economies, or SDEs, need a specific competition policy to create competitive markets? Against the backdrop of globalization, protectionist policies that promote state ownership and heavy regulation of key industries are proving increasingly ineffective for driving growth. Countries around the world are instituting reforms to promote competition and business creation, yet the economic and political concentration of power, feeble judicial systems, and the scarcity of human and financial resources pose special challenges to SDEs. Competition Policies in Emerging Economies features an in-depth analysis of two strategic industries — telecommunications and banking — in several Central American nations which sheds light on the dynamics of the transition to deregulation and trade liberalization. Examining the lessons learned from these experiences and presenting discussion of political, legal, economic, financial, cultural, and organizational issues, the book provides unique perspectives on competition policy and economic development.
Chinese Railways : Reform and Efficiency Improvement Opportunities
Although being huge by any measure, Chinese Railways are a bottleneck for economic growth in China. The state-owned enterprise returns a small profit but is severely capacity constrained and burdened with inefficiency. A comprehensive reform and efficiency improvement program needs to be developed in order to enable Chinese Railways to support further GDP growth in China. Application of industrial economics to the case of Chinese Railways suggests that moderate deregulation of e.g., the freight business could make Chinese Railways fit for future growth. Operational improvements need to complement this development, such as a redesign of the schedule or the introduction of value added services in the freight business. Based on interviews with Chinese experts, benchmarking with railways in the US, Germany, Russia, and Japan as well as broad coverage of Chinese-language sources, the book makes detailed recommendations on how to design a comprehensive turnaround program for Chinese Railways.
Cell Cycle Regulation
The cell cycle is tightly regulated on many different levels to ensure properly controlled proliferation. Deregulation of cell cycle regulation is a hallmark of cancer. In this book, many aspects of cell cycle regulation are discussed, which include G1, S, M phase control, ubiquitin-mediated degradation, DNA damage response, mitotic spindle checkpoint, the centrosome cycle, Retinoblastoma protein family, the Myc oncogene, and mouse models for tumor suppressors, cyclin-dependent kinases, and meiosis. These chapters written by experts provide an updated view on how the cell cycle is regulated in vivo and about the involvement of cell cycle regulators in cancer.
Breast cancer chemosensitivity
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.
Asymmetric Cell Division
Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
25 Years of P53 Research
Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. This book may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.
