الصفحة 1
الصفحة 1
Ondansetron Patches
The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.
Nutraceuticals : Sources, processing methods, properties, and applications
Explores the impact of nutraceutical compounds on human health and their main pharmacological contributions. Organized into three parts, this book addresses nutraceutical production, applications for disease prevention and treatment, and current trends, especially the role of nutraceuticals in cosmeceutical. Nutraceuticals are a class of products that can help people improve their health, reduce the risk of disease, extend their lives, and control the structure and functioning of their bodies. However, due to multiple hurdles that prevent nutraceuticals from circulating in an active form in the body, their use is associated with diminished therapeutic efficacy. Recognizing this problem, the book explores the root of the nutraceutical delivery system and its codelivery methods with a focus on medicines. With contributions from experienced nutraceutical experts, this book serves as a valuable reference for nutrition researchers, food scientists, pharmacologists, and those who are researching and studying in related areas.
Numerical computation, data analysis and software in mathematics and engineering
Include the aspects of the meshless method, numerical simulation, mathematical models, deep learning and data analysis. Meshless methods, such as the improved element-free Galerkin method, the dimension-splitting, interpolating, moving, least-squares method, the dimension-splitting, generalized, interpolating, element-free Galerkin method and the improved interpolating, complex variable, element-free Galerkin method, are presented. Some complicated problems, such as tge cold roll-forming process, ceramsite compound insulation block, crack propagation and heavy-haul railway tunnel with defects, are numerically analyzed.
Novel Drug Delivery Systems for Chinese Medicines
Describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.
Nicotine addiction and its treatment = إدمان النيكوتين وكيفية علاجه
Nicotine is the main cause of smoking addiction, and the custom of preparation for smoking itself and smell of cigarettes create addictive behavior among smokers. Today, nicotine is socially most widely accepted legal drug in the world, and its uptake into the organism through the respiratory tract is 10 times stronger than heroin. Addiction and necessity for cigarettes are constant and intense, and the treatment for smoking addicts is long and difficult. Smoking is a worldwide epidemic, which is closely connected to other addictions such as coffee, alcohol, drugs, and gambling. Smoking cessation is associated with clear health benefits. Cigarette smoking is the leading preventable cause of death in worldwide. In this project we will discuss the nicotine, the mechanism of its addiction and medications used for smoking cessation
New diagnostic method th detect peritoneal metastases in colorectal cancer
Colorectal cancer is the third common reason of death in population worldwide therefore we will focus in our study about description of this type of cancer and its symptoms to raise the public awareness to go to the right specialist as soon as the symptoms appear to improve early detection of this disease and the overall survival and we will highlight the best diet and life style to avoid this type of cancer hopefully beside that we will present all the most successful therapies of this disease from different classes of compounds such as chemotherapy or anti angiogenic and Metformin and other bacterial therapy however the major goal of the experimental part of this research is performed to establish a new promising diagnostic tool by Near Infra-red camera after injection of indyocine green to detection the peritoneal metastasis of colorectal in 15 patients since this kind of metastasis
New Aspects of Zirconium Containing Organic Compounds
Metal carbene complexes have made their way from organometallic curiosities to valuable reagents and catalysts. They offer novel synthetic opportunities in carbon-carbon bond formation based on either carbene-centered reactions or on metal-templated processes which makes them indispensable in modern synthetic methodology. The most prominent metal carbenes are now either commercially available or easy to synthesize and handle with modern laboratory techniques. This volume organized in eight chapters written by the leading scientists in the field illustrates the theoretical background, non-classical nucleophilic and cycloaddition patterns, chromium-templated benzannulation and photo-induced reactions, rhodium-catalyzed carbene transfer as well as the principles and applications of olefin metathesis which has coined the progress in synthetic methodology over the past decade. Designed for researchers in academia and industry as well as graduate students it presents the state-of-the-art potential of carbene complexes in modern organic synthesis.
New Aspects in Phosphorus Chemistry V
The use of polyphosphazenes as fluoroelastomers, flame retardants and self-extinguishing macromolecules, polymeric ionic conductors, biomaterials, and photosensitive polymeric compounds is outlined. This volume,as well as the four precedent volumes,describes only in part the huge number of original papers on phosphorus-related topics. Some further volumes will be necessary in the future to cover all aspects of this chemistry in perpetual rebirth.
Natural Products Targeting Clinically Relevant Enzymes
Covers the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Natural products and human diseases : Pharmacology, molecular targets, and therapeutic benefits
Provides insight into the clinical and translational application of natural products in human diseases Details the impact of natural products on a molecular basis Describes the identification of biomarkers, therapeutic effects of phytochemicals, and and new targets
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Natural poisons and venoms: Plant toxins : Polyketides, phenylpropanoids and further compounds
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural Compounds as Drugs ; Vol. II
This book highlights new trends and aspects in natural products research. It discusses the biodiversity-driven approaches which are now of eminent importance in natural products research, addressing the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Natural Compounds as Drugs ; Vol. I
This book highlights new trends and aspects in natural products research. It discusses the biodiversity-driven approaches which are now of eminent importance in natural products research, addressing the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Nanopharmaceuticals ; Vol.1 : Expectations and realities of multifunctional drug delivery systems
Reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.
Multiple Bonds between Metal Atoms
The 3rd edition of the Multiple Bonds between Metal Atoms deals with one of the most active fields of inorganic chemistry … . It presents an extensive, critical review and discussion of preparations, reactions, bonding, and physical properties of more than 4000 compounds … heartily recommend it to inorganic and materials chemists, and to all scientists concerned with the synthesis, spectroscopy, and structures of transition-metal compounds. It also belongs in academic, industrial, and government research libraries.
Multicomponent reactions towards heterocycles : Concepts and applications
Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs.
Monitors of Organic Chemicals in the Environment : Semipermeable Membrane Devices
Modern, industrialized societies depend on a wide range of chemical substances such as fuels, plastics, biocides, pharmaceuticals and detergents for maintaining the high quality lifestyle to which we aspire. The challenge is to ensure that while we enjoy the benetsof thes esubstances,theirinevitablereleaseintoourbiosphere does not result in unwanted human and ecosystem exposures, and the risk of - verse effects. One response to this challenge has been the extensive effort to detect and analyze or monitor a multitude of chemicals in a variety of environmental media, especially toxic organic compounds in air, water, soils and biota. An extensive literature on these traditional techniques has evolved over the years.
Molluscs : From Chemo-ecological Study to Biotechnological Application
Marine molluscs are very promising candidates for a wide range of biotechnological applications. For example, they possess analgesic drugs more potent than morphine and very effective anticancer agents. The present book gives an up-to-date overview of the main classes of bioactive compounds from molluscs, moving from ecological observations, to chemical characterization, to biosynthesis, to large-scale synthesis, and to pharmacological applications. A truly outstanding international panel of experts from all continents provides complete coverage of the most stimulating topics related to molluscs. This knowledge of their history and current studies provides an open door to the future.
Molecular Pharmacognosy
This book discusses the application of molecular biology in resource science and authentication of traditional Chinese medicine (TCM). It also reviews the latest developments in pharmacognosy, introduces new perspectives and insights, discusses the hotspots and focuses in the field of molecular pharmacognosy, and predicts new directions of study. In the last five years, the technologies and scope of molecular pharmacognosy have constantly expanded and evolved. As such, this new edition includes extra content, such as the molecular phylogeography of medicinal plants, functional genome of medicinal plants, and synthetic biology of active compounds. Elucidating the concept, theory, and methodology of molecular pharmacognosy, it promotes the full use of the newly developed technologies and methodologies within the framework of molecular pharmacognosy to solve problems in the field.
