الصفحة 1
الصفحة 1
Novel Carrier Systems for Targeted and Controlled Drug Delivery
Presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers.
Nanostructured Soft Matter : Experiment, Theory, Simulation and Perspectives
This book provides an interdisciplinary overview of a new and broad class of materials under the unifying name Nanostructured Soft Matter. It covers materials ranging from short amphiphilic molecules to block copolymers, proteins, colloids and their composites, microemulsions and bio-inspired systems.
Nanoscale Assembly : Chemical Techniques
Recent advances have pushed the limits of lithography firmly into the sub-100 nm domain, with smallest feature sizes around 10 nm. However, compared to living organisms, devices fabricated using nanolithography are not nearly as complex, as they are essentially 2D and contain only a limited number of chemical elements. For centuries, Nature has been a major inspiration for science. First of all to learn how Life functions at cellular level, but increasingly, as a blueprint for designing non-natural devices where the building blocks and their assembly are inspired by biological examples. The key tool in translating these examples into the domain of engineering, has been self-assembly or self-organization. This book gathers a spectrum researchers who have not only furthered our knowledge of self-assembly using small molecules, polymers and colloidal particles as building blocks, but who have also shown it to be a practical tool in the assembly of an astonishing variety of devices, ranging from molecular electronics to biosensors.
N4-Macrocyclic Metal Complexes
The study of nanoparticles is anchored in Colloid Science. Colloid Science as we consider it today was nucleated by Wolfgang Ostwald and initiated by his biological studies. The strong connection between biology and Colloid Science lost attractiveness in the last decades. The revival of this interdisciplinary science is now noted and we hope that a signal will start from the Potsdam conference. "This is an excellent and detailed book of 14 chapters that is timely in its reviews of the electrochemical and electrocatalytic properties of the porphyrinoids and is written by a range of experts in the different fields covered.
Molecular Organisation on Interfaces
This volume contains studies on the molecular organisation on interfaces and nanoparticles. The contributions were presented during the 40. General Meeting (Hauptversammlung) of the Kolloid-Gesellschaft in Potsdam in September 2001 and are related to the subject "Colloids and Life Science". Therefore, a diversity of papers were collected covering a large field: synthesis of polymer colloids, biominerals and nanoparticles, investigations on monolayers, lyotropic mesophases, polymeric surfactants, micellar transitions, supramolecular compounds for modifying polymers, solid particles for emulsion stabilisers, and adsorbents for odour control.
Modern treatments for chronic blood diseases
Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. In vertebrates, it is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloida osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). Thalassemias are inherited blood disorders characterized by decreased hemoglobin production Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.
Medical Applications of Colloids
This volume collects chapters dealing with significant topics in colloids and surfaces relevant to medical applications. The book will be of interest to scientists and practitioners in areas as diverse as medical diagnostics, drug formulations, X-ray photoelectron spectroscopy of biomaterials, and particle transport in human airways.
Interfacial Processes and Molecular Aggregation of Surfactants
Given the enormous interest in surface phenomena in areas ranging from materials science to applications in life science, this volume is a very timely addition to the literature. Emphasis is on surfactants mediating interfacial and molecular aggregation phenomena, and the following topics are reviewed in particular: dissolution rates, equilibrium adsorption, mixing rules, and spreading on a solid surface of surfactants, as well as the role of surfactants in mediating a range of processes, such as the fabrication of various nanomaterials.
Integrated Molecular and Cellular Biophysics
Biophysics represents perhaps one of the best examples of interdisciplinary research areas, where concepts and methods from disciplines such as physics, biology, b- chemistry, colloid chemistry, and physiology are integrated. It is by no means a new ?eld of study and has actually been around, initially as quantitative physiology and partly as colloid science, for over a hundred years. For a long time, biophysics has been taught and practiced as a research discipline mostly in medical schools and life sciences departments, and excellent biophysics textbooks have been published that are targeted at a biologically literate audience. With a few exceptions, it is only relatively recently that biophysics has started to be recognized as a physical science and integrated into physics departments’ curr- ula, sometimes under the new name of biological physics.
Hydrogels : Design, Synthesis and Application in Drug Delivery and Regenerative Medicine
Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions.
Functional Hydrogels in Drug Delivery : Key Features and Future Perspectives
Deals with the synthesis and characterization of hydrogels specifically used as drug delivery systems. Each chapter includes the most recent updates about the different starting materials employed--whether natural and synthetic--and the improvement, such as modifications of synthetic approach and polymerization technique, of their physicochemical and biological properties to synthetize high performing carriers for specific uses, i.e. stimuli-responsive materials, molecularly imprinted polymers, mucoadhesive materials, carrier for the delivery of high molecular weight drugs, and gene-delivery.
Forces, Growth and Form in Soft Condensed Matter : At the Interface between Physics and Biology
This volume comprises the proceedings of a NATO Advanced Study Institute held at Geilo, Norway, 24 March - 3 April 2003, the seventeenth ASI in a series held every two years since 1971. The objective of this ASI was to identify and discuss areas where synergism between modern physics, soft condensed matter and biology might be most fruitful. The main pedagogical approach was to have lecturers focussing on basic understanding of important aspects of the relative role of the various interaction- electrostatic, hydrophobic, steric, conformational, van der Waals etc. Soft condensed matter and the connection between physics and biology have been the themes of several earlier Geilo Schools. A return to these subjects thus allowed a fresh look and a possibility for defining new directions for research. Examples of soft materials, which were discussed at this ASI, included colloidal dispersions, gels, biopolymers and charged polymer solutions, polyelectrolytes, protein/membrane complexes, nucleic acids and their complexes. Indeed, most forms of condensed matter are soft and these substances are composed of aggregates and macromolecules, with interactions that are too weak and complex to form crystals spontaneously. A characteristic feature is that small external forces, slight perturbations in temperature, pressure or concentration, can all be enough to induce significant structural changes. Thermal fluctuations are almost by definition strong in soft materials and entropy is a predominant determinant of structure, so that disorder, slow dynamics and plastic deformation are the rule. Hence the phrase ‘soft condensed matter’ has been coined.
Food Materials Science : Principles and Practice
Food manufacture is about producing billions of units of standardized products which must be cheap, nutritious, safe and appealing to the consumer’s taste. Food products are complex multicomponent and structured edible materials that nevertheless must comply with the laws of physics and fundamentals of engineering sciences. In the last 20 years the design of food products with specific functionalities has advanced significantly by the application of scientific knowledge from disciplines such as polymer physics, colloidal and mesoscopic physics, materials science and new imaging and probing techniques borrowed from chemistry, biology and medicine. Our knowledge of the relationship between microstructure, processing, and macroscopic properties continues to increase as the science of food materials advances at a fast pace.
Dendrimer Catalysis
catalytically active dendrimers have emerged as a class of molecular catalysts that has substantially enriched the field of homogeneous (and in part heterogeneous) catalysis. A general survey of transition metal dendrimer catalysts and the way they have developed is followed by in-depth discussions of dendritic transition metal catalysis based on non-covalent catalyst-support interaction and an overview of the rapidly growing field of stereoselective dendrimer catalysis. The development of dendrimer-encapsulated bimetallic nanoparticles has provided the interface with heterogeneous colloid catalysis. As cheaper and readily accessible alternatives to regular dendrimers, hyperbranched polymers are increasingly being used as catalyst platforms. These topics are complemented by a review of metallodendritic exoreptors for the redox recognition of oxo-anions and halides.
Conformation-Dependent Design of Sequences in Copolymers II
The book include : 1 V.O. Aseyev, H. Tenhu, F. Winnik: Temperature Dependence of the Colloidal Stability of Neutral Amphiphilic Polymers in Water.- 2 V.I. Lozinsky: Approaches to Chemical Synthesis of Protein-Like Copolymers.- 3 S.I. Kuchanov, A.R. Khokhlov: Role of Physical Factors in the Processes of Obtaining of Copolymers.- 4 A.Y. Grosberg, A.R. Khokhlov: After-Action of the Ideas of I.M. Lifshitz in Polymer and Biopolymer Physics.-
Conformation-Dependent Design of Sequences in Copolymers I
The book include : *Computer-aided conformation-dependent design of copolymer sequences *Folding and Formation of Mesoglobules in Dilute Copolymer Solutions *Water solutions of amphiphilic polymers : nanostructure formation and possibilities for catalysis Temperature Dependence of the Colloidal Stability of neutral amphiphilic polymers in water *Approaches to chemical synthesis of protein like copolymers *Role of physical factors in the process of obtaining copolymers *After-action of the ideas of I.M. Lifshitz in polymer and biopolymer physics
Computer simulations in condensed matter : From materials to chemical biology ; Vol.2
This extensive and comprehensive collection of lectures by world-leading experts in the field introduces and reviews all relevant computer simulation methods and their applications in condensed matter systems. Volume 1, published as LNP 703 (ISBN 3-540-35270-8) is an in-depth introduction to a vast spectrum of computational techniques for statistical mechanical systems of condensed matter. It will enable the graduate student and both the specialist and nonspecialist researcher to get acquainted with the tools necessary to carry out numerical simulations at an advanced level. The present volume is a state-of-the-art survey on numerical experiments carried out for a great number of systems, ranging from materials sciences to chemical biology, such as supercooled liquids, spin glasses, colloids, polymers, liquid crystals, biological membranes and folding proteins.
Computational methods for nanoscale applications : Particles, plasmons and waves
Computational Methods for Nanoscale Applications: Particles, Plasmons and Waves presents new perspectives on modern nanoscale problems where fundamental science meets technology and computer modeling. This book describes well-known computational techniques such as finite-difference schemes, finite element analysis and Ewald summation, as well as a new finite-difference calculus of Flexible Local Approximation MEthods (FLAME) that qualitatively improves the numerical accuracy in a variety of problems. Application areas in the book include long-range particle interactions in homogeneous and heterogeneous media, electrostatics of colloidal systems, wave propagation in photonic crystals, photonic band structure, plasmon field enhancement, and metamaterials with backward waves and negative refraction.
Colloids for Nano- and Biotechnology
This volume contains a selection of the papers presented at the 9th Conference on Colloid Chemistry. A colloid chemical approach to nano- and biotechnology was one of the main topics of the meeting held in Siófok, Hungary in October 2007. It was organized by the Hungarian Chemical Society in cooperation with leading Hungarian universities and the Hungarian Academy of Sciences. The contributions demonstrated the progress of the field and supported that "The world of neglected dimensions" should not be neglected at all in modern material sciences and technologies. This volume is intended for professionals dealing with fundamental research or development of industrial applications, who encounter colloids, nanostructures, and interfacial phenomena during their work.
Colloidal Transport in Porous Media
Colloids are known to be the often neglected phase for the transport of pollutants in aquatic ecosystems. The book covers the basics of abiotic colloid characterization, of biocolloids and biofilms, the resulting transport phenomena and their engineering aspects. The subject is presented from an international group of leading specialists devoted to colloidal sciences. The contributions include theoretical considerations, results from model experiments as well as field studies. The information given will serve students and scientists interested in the analytical, chemical, microbiological, geological and hydrological aspects of material transport in aquatic systems and soils.
