الصفحة 1
الصفحة 1
Ultrasound of the Gastrointestinal Tract
Transabdominal ultrasound has become accepted in clinical practice as a primary imaging procedure in the diagnostic work-up and follow-up of various disorders of the gastrointestinal tract. This book provides a comprehensive overview of the use of ultrasound in the imaging of acute and chronic inflammatory conditions of the gastrointestinal tract as well as of neoplastic and infectious diseases. The specific ultrasound features of gastrointestinal disorders are explained, and the value and limits of ultrasound are discussed. Each chapter provides a description of the findings obtained with ultrasound imaging, with inclusion of alternative diagnostic imaging methods for comparative purposes. Specific technical developments and applications of ultrasound relevant to studies of the gastrointestinal tract, such as functional and 3D ultrasound, contrast agents and operative ultrasound, are also discussed.
Toll-like Receptors in Inflammation
Toll-like receptors (TLRs) are critical mediators of the innate immune response in mammals. This family of receptors recognizes a variety of microbial products or motifs and initiates the host response to infection. Examples include TLR4 which recognizes lipopolysaccharide (LPS) from Gram-negative bacteria, TLR3 which recognizes viral double-stranded RNA, and TLR9 which recognizes CpG DNA motifs, found in both viruses and bacteria. All TLRs possess an intracellular region termed the Toll-IL-1 receptor-Resistance (TIR) domain which is essential for signaling from these receptors. The specificity of signaling from individual TLRs arises from differential utilization of adapter proteins. This specificity results in a tailoring of the host defense response depending on the microbe being sensed. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis, and asthma. There is, therefore, great interest in targeting TLRs therapeutically since a disruption of TLR function will result in a decrease in the production of inflammatory mediators.
Therapeutic Management of Incontinence and Pelvic Pain : Pelvic Organ Disorders
Chapters include coverage of the management and treatment of bladder and bowel dysfunctions in men and women, pelvic organ prolapse; issues concerning the elderly, neurologically impaired patients and those with pelvic pain. Allied updated chapters are presented on research methodology, the importance of fluids and infection control. Other new chapters are concerned with quality of life, the treatment of bladder and bowel dysfunction in children, the history of pelvic floor muscle exercise and manual therapy. In addition, the use of real-time ultrasound to evaluate pelvic floor muscle contractility, exercise balls to promote coordination of trunk stabilisers and the pelvic floor muscles, and the role of the Occupational Therapist in the continence service are discussed. Finally, a new section on ethical issues regarding the management of incontinence completes this well-illustrated text.
The future of capsule endoscopy from diagnostic to therapeutic experimental prototype capsule
Capsule endoscopy (CE) is indicated as a first-line clinical examination for the detection of small-bowel pathology, and there is an ever-growing drive for it to become a method for the screening of the entire gastrointestinal tract (GI). However systemic side effects of medications in the field of pharmacology is a huge obstacle for administration mainly in age related diseases therefore although CE's main function is diagnosis, our research for therapeutic capabilities has intensified to make therapeutic capsule endoscopy (TCE) a target within reach.
Small Bowel Obstruction : CT Features with Plain Film and US correlations
The aim of this book is connect pathophysiology to imaging using many illustrations and examples, emphasizing the capabilities and limitations of multidetector computed tomography and its role in the correct management approach to these disorders. Furthermore, the place of allied imaging modalities (plain film and ultrasound) in the clinical algorithm is comprehensively illustrated.
Scheins Common Sense Emergency Abdominal Surgery
Emergency Abdominal Surgery is a battlefield for the surgeon - providing character-building experiences, and opportunities for triumph and disaster. In the second edition of this 'simple' book emergency abdominal surgery is discussed in an informal and no nonsense fashion - as practiced in the 'trenches' of the ER and the OR. The preferred approach for a given situation is discussed in context; it has to fulfill certain prerequisites: save live, decrease morbidity, be cost effective and be performed correctly.
Reoperative Pediatric Surgery
Reoperative surgery is a prevailing challenge faced by pediatric surgeons. Reoperative Pediatric Surgery constitutes in one volume the most up to date information and techniques for critical cases in all of the pediatric surgical specialties including oncology, gastroenterology, gynecology, urology, radiology, and cardiology. Recognized experts impart their knowledge of indications for reoperative surgeries, radiologic evaluation, surgical procedures which may require seldom used and extremely complex techniques, and the risks and outcomes of these specialized approaches. These practicing surgeons provide insight into intricate corrective procedures involving the placement of grafts, stents, and supports with necessary forecasting for complications arising from anatomic growth and disease recurrence.
Radiological Imaging of the Digestive Tract in Infants and Children
This comprehensive, up-to-date and extensively illustrated volume offers a multimodality approach to gastrointestinal imaging in children and infants. The role of each of the currently available imaging techniques is considered carefully, and diagnostic dilemmas are discussed and illustrated. After an initial chapter that addresses pediatric gastrointestinal imaging in the emergency setting, detailed individual chapters are devoted to the esophagus, stomach and duodenum, accessory organs of digestion, small bowel and colon. A closing chapter focuses on pediatric interventional procedures performed with imaging guidance. Against the background of rapid recent advances in imaging technology and the distinctive aspects of gastrointestinal imaging in children and infants, this volume will serve as an essential reference work for all who are engaged in the field.
Quantitative pharmacology and individualized therapy strategies in development of therapeutic proteins for immune-mediated inflammatory diseases
Discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins / Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) / Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus
Psychosomatics diseases
Psychosomatics definition is a branch of medicine that deals with psychosomatic diseases which are diseases in which the mental and psychological factors of the patient greatly influence their emergence, development and turbulence, such as: migraine, eczema, ulcers, irritable bowel ... Etc., and in the event of a medical examination, no physical or organic causes appear for these diseases, or in the event of a disease resulting from an emotional or mood state such as anger, anxiety, depression, or guilt, in this case such cases are considered psychosomatic diseases. Psychosomatic diseases differ from transformational hysteria in that hysteria does not include a true organic defect, where the organ is healthy but is unable to perform its function, while in psychosomatic diseases, emotional and psychological factors lead to a defect in the anatomical formation of the affected organ, such as cases of stomach ulcers or inflammation Joints..etc.
Probiotics : The future to lowering blood pressure
The intestines harbor a complex array of microorganisms collectively known as the gut microbiota. The past two decades have witnessed increasing interest in studying the gut microbiota in health and disease, largely driven by rapid innovation in high-throughput multi-omics technologies. As a result, microbial dysbiosis has been linked to many human pathologies, including type 2 diabetes mellitus, inflammatory bowel disease, and hypertension. Probiotics, contained in yogurt, fermented milk, cheese, and in supplements act beneficially by improving the microbial balance of the gut, promoting diversity, stability, remodeling of gut microbiota, regulating the body’s inflammatory state, enhancing the intestinal mucosal barrier function, and maintain blood pressure levels as part of a healthy lifestyle.
Principles and practice of phytotherapy : Modern herbal medicine
Covers all major aspects of herbal medicine from fundamental concepts, traditional use and scientific research through to safety, effective dosage and clinical applications. Written by herbal practitioners with active experience in clinical practice, education, manufacturing and research, the textbook is both practical and evidence based. The focus, always, is on the importance of tailoring the treatment to the individual case. New insights are given into the herbal management of approxiately 100 modern ailments, including some of the most challenging medical conditions, such as asthma, inflammatory bowel disease and other complex autoimmune and inflammatory conditions, and there is vibrant discussion around the contribution of phytotherapy in general to modern health issues, including health ageing.
Pediatric Inflammatory Bowel Disease
Pediatric Inflammatory Bowel Diseases (IBD) are the most common and most significant chronic disorders in Pediatric Gastroenterology. The onset of Crohn disease and ulcerative colitis in the first two decades of life presents a number of diagnostic and therapeutic challenges that are unique to pediatric patients. Although the studies available for pediatric diagnosis have improved dramatically in the past three decades, the improvement in technology alone cannot account for the increased frequency of IBD recognized in early childhood. While therapy for older patients has improved dramatically with the use of immunomodulators and the development of exciting biologic strategies, rarely if ever have comprehensive studies of the pharmacokinetics, safety and efficacy of any of the IBD medications been performed in pediatric patients. A number of excellent medications are not available in liquid preparations that can be swallowed by children, and others, such as timed-release formulations, are developed for delivery to an adult gastrointestinal tract. It is unfortunate that the care we provide to children is often an extrapolation of what is known about and available for adults with IBD. Pediatric patients with IBD face a number of unique challenges.
Operative Neuromodulation ; Vol.2 : Neural Networks Surgery
Neuromodulation is a rapidly evolving multidisciplinary biomedical and biotechnological field.This volume present the state-of-the-art in established and emerging applications for pain, spasticity, movement disorders, bladder and bowel dysfunction, cardiovascular disease, epilepsy, psychiatric illness, impairment of hearing and vision, and computational neuromodulation. Experts describe the neural networks involved and the appropriate surgical approaches, provide clinical guidelines, technical descriptions of implanted devices, proposals for refinements and personal views on future prospects of the field. It also describes the techniques and procedures applied by direct a) contact with the central nervous system or cranial nerves, in order to modulate the function of neural networks as in the case of motor cortext stimulation for pain or vagus nerve stimulation for epilepsy, or b) in deeply located structures inside the nervous system, in order to alter the function on specific networks as in the case of deep brain stimulation for Parkinson’s disease.
Operative Neuromodulation ; Vol.1 : Functional Neuroprosthetic Surgery. An Introduction
Neuromodulation is a rapidly evolving multidisciplinary biomedical and biotechnological field. The two volumes present the state-of-the-art in established and emerging applications for pain, spasticity, movement disorders, bladder and bowel dysfunction, cardiovascular disease, epilepsy, psychiatric illness, impairment of hearing and vision, and computational neuromodulation. Experts describe the neural networks involved and the appropriate surgical approaches, provide clinical guidelines, technical descriptions of implanted devices, proposals for refinements and personal views on future prospects of the field. Volume I describes techniques and procedures applied in internal contact with non-neural tissues surrounding the nervous system (dura or cerebrospinal fluid), as in the case of epidural stimulation for pain, etc. or intrathecal drug application for the treatment of spasticity and pain. There is also a special section on non-invasive functional neuroprosthetic systems, which are usually applied by transcutaneous contact with the nervous system.
Nutrition and Gastrointestinal Disease
Nutritional support of people with gastrointestinal impairment is critical to treatment and ultimately successful management. As such, gastroenterologists should be experts in nutrition and knowledgeable about the affects of nutrition on disease management. Nutritional and Gastrointestinal Disease fulfills that need, serving as a hands-on, practical reference in nutrition support for the clinical gastroenterologist and other clinicians with similar interests. The volume offers expert nutritional knowledge and management ideas as well as methodology for combating problems such as short bowel syndrome, inflammatory bowel disease, celiac disease and obesity. Renowned authorities also investigate nutrition’s influence on such issues as liver failure and acute pancreatitis. While gastroenterology training programs around the world remain deficient in their nutrition curriculum, Nutritional and Gastrointestinal Disease provides a comprehensive and groundbreaking support for clinical gastroenterologists.
Nutraceutical fruits : Overview and disease prevention
While nutritional supplements have enormous advantages, food ingredients such as fruits and vegetables can play a significant preventative and therapeutic role in our daily lives. Fruits are found to have anti-inflammatory, antibacterial, antifungal, and chemopreventive properties that can boost health, as well as prevent diseases. This new book explores the use of fruits as nutraceuticals for alternative treatment, as well as for disease prevention. It looks at how nutraceutical fruits can be used to prevent and manage a range of diseases that include mental illness, cancer, respiratory and lung diseases, cardiovascular diseases, liver disease, inflammatory bowel diseases, sleep disorders, etc. The book also looks at the roles of nutraceutical fruits in the metabolic syndrome and provides information regarding the safety and toxicity of neutraceutical fruits.
Irritable Bowel syndrome I.B.S
Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder with a range of symptoms that significantly affect quality of life for patients. Is currently one of the most common disorders of the digestive system in the Western society? Almost 2 out of 10 people suffer from IBS, and it is associated with abdominal pain, bloating and altered stool consistency and imposes a heavy burden for the affected patients. The difficulty of differential diagnosis and its treatment may significantly delay initiation of optimal therapy. Hence, persons with IBS often self-treat symptoms with non-prescribed pharmacological regimens and/or complementary and alternative medicines (CAM) and by modifying diet and daily activities.
Inflammatory Bowel Disease and Familial Adenomatous Polyposis : Clinical Management and Patients' Quality of Life
Inflammatory bowel disease (IBD) and familial adenomatous polyposis (FAP) are complex diseases, which are subject to numerous medical researches. IBD and FAP represent a challenge for a multidisciplinary medical approach where different personnel play major roles in different stages of the patient’s treatment.
Inflammatory Bowel Disease : From Bench to Bedside
Inflammatory Bowel Disease: From Bench to Bedside is a detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders are explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.
