الصفحة 1
الصفحة 1
Novel mouse model for future autism research
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures in the first 3 years of life. It is not a single disorder, and it is broadly considered to be a multi-factorial disorder resulting from genetic and non-genetic risk factors and their interaction. Genetic studies of ASD have identified mutations that interfere with typical neurodevelopment in utero through childhood. These complexes of genes have been involved in synaptogenesis and axon motility. Recent developments in neuroimaging studies have provided many important insights into the pathological changes that occur in the brain of patients with ASD in vivo. Especially, the role of amygdala, a major component of the limbic system and the affective loop of the cortico-striatothalamo-cortical circuit, in cognition and ASD has been proved in numerous neuropathological and neuroimaging studies.
Next generation information technologies and systems ; 6th International Conference, NGITS 2006, Kebbutz Sehfayim, Israel, July 4-6, 2006, Proceedings
The selected papers may be classified roughly in ten broad areas: ? Information systems development ? Distributed systems ? Semi-structured data ? Data mining and agent-oriented computing ? User-oriented design ? Frameworks, models and taxonomies ? Simulation and incremental computing ? Information integration ? Security and privacy ? Next-generation applications This event is the culmination of efforts by many talented and dedicated individuals.
New Dimensions of Business Reporting and XBRL
The authors of this book analyse the social and technical nature and role of XBRL in information supply chains and capital markets as well as the XBRL standard and taxonomies. They provide a critical view of XBRL from a research perspective, present different projects in the XBRL area and indicate future directions for XBRL research. Current research questions are taken up and discussed from different perspectives. From a technical point of view, the research spectrum encompasses the internal perspective up to the final user layer. Apart from these technical issues, there are also key socio-technical aspects which are vital to the understanding of XBRL use.
Neuronal cell death : Methods and protocols
Covers comprehensive methods on ways to assess structural and ultrastructural changes in the mitochondria, cytoskeleton, and microglia using state-of-the-art microscopy techniques including super-resolution imaging, electron microscopy, and ultra-high field MRI. The chapters in this book cover topics such as analysis of neurodegeneration in the post-mortem characterization of preclinical animal models, in vivo modeling in cell death in different model systems and brain organoids, single cell clonal analysis using Mosaic Analysis with Double Markers in genetic mouse models, and genome and proteomic methods for analysis of mRNA dynamics and quantitation of targeted peptides.
Multiple Sclerosis: Autoimmunity and Management
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20–25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or years apart and affect different anatomic locations. Also, see the Autoimmune Disorders: Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. MS is diagnosed on the basis of clinical findings and supporting evidence from ancillary tests. Treatment consists of immunomodulatory therapy for the underlying immune disorder and management of symptoms, as well as nonpharmacologic treatments, such as physical and occupational therapy. Disease-modifying therapies have shown beneficial effects in patients with relapsing MS, including reduced frequency and severity of clinical attacks. These agents appear to slow the progression of disability and the reduce accumulation of lesions within the brain and spinal cord.
Multimedia big data computing for IoT applications : Concepts, paradigms and solutions
This book considers all aspects of managing the complexity of Multimedia Big Data Computing (MMBD) for IoT applications and develops a comprehensive taxonomy. It also discusses a process model that addresses a number of research challenges associated with MMBD, such as scalability, accessibility, reliability, heterogeneity, and Quality of Service (QoS) requirements, presenting case studies to demonstrate its application. Further, the book examines the layered architecture of MMBD computing and compares the life cycle of both big data and MMBD. Written by leading experts, it also includes numerous solved examples, technical descriptions, scenarios, procedures, and algorithms.
Monograph of the Urostyloidea (Ciliophora, Hypotricha)
This monograph is the second of a series treating the hypotrichs, a major part of the spirotrichous ciliates. The urostyloids are characterised by a zigzag-arrangement of the ventral cirri. Like the first part of the series, the Oxytrichidae, it summarises the morphological, morphogenetic, faunistic, and ecological data from the past 230 years, scattered in more than 1300 references from all over the world. Dichotomous keys lead to 36 genera and subgenera comprising 153 species illustrated by more than 2100 figures, including original ones. The treatise offers taxonomists, cell biologists, and ecologists a thorough and up-to-date revision because for each species a detailed list of synonyms, a discussion of the nomenclature and systematics, and an extensive description of the morphology and ecology, including almost all published faunistic records, are provided. With the monographs of the Urostyloidea and the Oxytrichidae the interested scientist can identify more than 320 species of hypotrichs, which are an important component of the eukaryotic microbial life in limnetic, marine, and terrestrial habitats.
Monograph of the Spathidiida (Ciliophora, Haptoria) ; Vol. I : Protospathidiidae, Arcuospathidiidae, Apertospathulidae
The present monograph carefully revises the taxonomy, nomenclature, and ecology of all nominal species and shows that spathidiid diversity has been greatly underestimated. Based on the reinvestigation of described species with modern methods (silver impregnation, scanning electron microscopy) and the first description of over 50 new species, the family Spathidiidae is split into four families and 20 genera. Each species is described and figured in detail, making it unnecessary to go back to the original literature often difficult to obtain. Two identification keys are provided, viz., one for taxonomists and another, simple key for users not specifically trained in ciliate taxonomy.
Modern Food Microbiology
With 30 revised and updated chapters, the new edition of this classic text brings benefits to professors and students alike who will find new sections on proteobacteria, bottled water, food sanitizers (eletrolyzed oxidating water, ozone, chlorine, activin, chitosans, endolysins, etc.), bicontrol, biosensors quorum sensing, molecular genetic methods of analysis, food safety objectives, noroviruses, and prions. The book builds on the trusted and established sections on food preservation by modified atmosphere, high pressure and pulsed electric field processing, food-borne pathogens, food regulations, fresh-cut produce, new food products, and risk assessment and analysis. In-depth references, appendixes, illustrations, index and thorough updating of taxonomies make this an essential for every food scientist.
Modern asset allocation for wealth management
This book provides a complete taxonomy of modern methods for constructing investment portfolios. It goes beyond the simplest models and heuristics that are commonly used today and brings advances that are otherwise buried in Ph.D.-level mathematics to the financial advisor community. It covers all aspects of creating client portfolios, including choosing asset classes to invest in, selecting securities within asset classes, client risk preference assessment, portfolio construction, and portfolio rebalancing.
Mobile response ; 1st International Workshop on mobile information technology, for emergency response, mobile response 2007, Sankt Augustin, Germany, February 22-23, 2007. Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Mobile Information Technology for Emergency Response, MobileResponse 2007 held in Sankt Augustin, Germany in February 2007.
Micromammals and Macroparasites : From Evolutionary Ecology to Management
Small mammals are among the most ubiquitous and important components of terrestrial ecosystems. They have coevolved, and now coexist, with a diverse array of parasites, such that not only are all aspects of their biology influenced by parasitism but they also play key roles in the transmission and maintenance of parasitic diseases. This book provides a comprehensive survey of the diversity and biology of metazoan parasites affecting small mammals, of their impact on host individuals and populations, and of the management implications of these parasites for conservation biology and human welfare. Designed for a broad, multidisciplinary audience, it will be an essential resource for researchers, students, and practitioners alike in the fields of parasitology, evolutionary ecology, wildlife management, and conservation biology.
Microbial Phosphate Solubilization
Last decade has seen a significantly increased knowledge about phosphate solubilizing microorganisms. Sixty specialists from thirteen countries met in Salamanca to discuss the problems of the high P-unavailability as a soil nutrient for crops, and the hazards of an increasing phosphate input to aquatic habitats from industrial and mining activities, sewage disposal, detergents, and other sources. Updated solutions to enhance P-uptake by plants, bioremediation potential in the rehabilitation of ecosystems, taxonomic characterization interactions with mycorrizae, the physiological and molecular basis of PSM, and possibilities of genetic modifications of rhizospheric microorganisms were among the contributions presented. Challenges in commercializing a phosphate solubilizing microorganism were also outlined by a relevant biotech company.
Intersecting colors : Josef Albers and his contemporaries
Offers a timely reappraisal of the immense impact of Albers's thinking, writing, teaching, and art on generations of students. It shows the formative influence on his work of non-scientific approaches to color (notably the work of Johann Wolfgang von Goethe) and the emergence of Gestalt psychology in the first decades of the twentieth century. The work also shows how much of Albers's approach to color-dismissed in its day by a scientific approach to the study and taxonomy of color driven chiefly by industrial and commercial interests-ultimately anticipated what neuroscience now reveals about how we perceive this most fundamental element of our visual experience.
International Handbook of Juvenile Justice
This comprehensive reference work presents an in-depth analysis on the juvenile justice systems of 19 different countries, both in EU-member states (old and new) and in the United States and Canada. The book is the result of research conducted by a group of outstanding scholars working in the field of juvenile justice. The book reflects a collective concern about trends in juvenile justice over the past two decades; trends that have begun to blur the difference between criminal and juvenile justice. The introduction highlights similarities and differences between the various systems, identifying three clusters of countries with a similar approach to juvenile justice. In particular, differences are found between the Anglo-Saxon countries, and continental Europe.
Inglese per radiologi : Scrivere, presentare e comunicare in ambito internazionale = Imaging in vascular emergencies - Body : Case studies for Radiologists : Writing, presenting and communicating internationally
The volume deals with the different aspects and multiple applications of radiological English, providing useful suggestions for preparing a scientific work, for understanding the meaning of abbreviations and acronyms commonly used in the Anglo-Saxon language, for presenting a report to a congress international or to moderate a scientific session.
Indian Medicinal Plants : An Illustrated Dictionary
This volume lists the taxonomy and medicinal usage of Indian plants. Also given are both traditional Indian and international synonyms along with details of the habitats of the plants. Indian Medicinal Plants. An Illustrated Dictionary is aimed at bringing out an updated Acute Study Dictionary of plant sources of Indian medicine. The text is based on authentic treatises which are the outcome of scientific screening and critical evaluation by eminent scholars.
Hybrid metaheuristics ; Vol. 3636 ; 2nd International Workshop, HM 2005, Barcelona, Spain, August 29-30, 2005. Proceedings
Constitutes the refereed proceedings of the Second International Workshop on Hybrid Metaheuristics, HM 2005, held in Barcelona, Spain, in August 2005. In this book, the papers addresses topics such as: low-level hybridization, high-level hybridization, portfolio techniques, expert systems, co-operative search, taxonomy, terminology, and more.
Handbook of Pathogens and Diseases in Cephalopods
The aim of this book is to facilitate the identification and description of the different organs as well as pathogens and diseases affecting the most representative species of cephalopods focussed on Sepia officinalis, Loligo vulgaris and Octopus vulgaris. These species are valuable ‘morphotype’ models and belong to the taxonomic groups Sepioidea, Myopsida and Octopoda, which include most of the species with a high market value and aquaculture potential. The study is based on photographs at macroscopic and histological level in order to illustrate the role of the most important pathogens and related diseases from the view of a pathological diagnosis. The reader is able to familiarize with functional anatomy, necropsy and general histology of adults and paralarvae, as well as with the identification of different pathogens and pathologies. This work is thus an invaluable guide for the diagnosis of cephalopod diseases. Besides including pathogens for non-European cephalopod species, it also provides a useful contribution encouraging marine pathologists, parasitologists, veterinarians and those involved in fishery sanitary assessments, aquarium maintenance and aquaculture practices aiming to increase their knowledge about the pathology of cephalopods.
Handbook of neurochemistry and molecular neurobiology : Sensory neurochemistry
This volume of the Handbook of Neurochemistry and Molecular Biology focuses on molecular events involved in synapse formation, synaptic plasticity and ongoing neural activity. The volume explores axonal growth cones, synapse development, and mechanisms of LTP and LTD, and calcium dynamics.
