الصفحة 1
الصفحة 1
Nutraceutical fruits : Overview and disease prevention
While nutritional supplements have enormous advantages, food ingredients such as fruits and vegetables can play a significant preventative and therapeutic role in our daily lives. Fruits are found to have anti-inflammatory, antibacterial, antifungal, and chemopreventive properties that can boost health, as well as prevent diseases. This new book explores the use of fruits as nutraceuticals for alternative treatment, as well as for disease prevention. It looks at how nutraceutical fruits can be used to prevent and manage a range of diseases that include mental illness, cancer, respiratory and lung diseases, cardiovascular diseases, liver disease, inflammatory bowel diseases, sleep disorders, etc. The book also looks at the roles of nutraceutical fruits in the metabolic syndrome and provides information regarding the safety and toxicity of neutraceutical fruits.
Nimesulide - Actions and Uses
Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) which acts as a cyclooxygenase- 2 inhibitor but also has other novel pharmacological features which account for its effect in the control of pain and inflammation. It has become a leading NSAID in over 50 countries worldwide. This book provides a comprehensive and fully up-to-date critical review of the published literature on nimesulide, including comparisons with anti-inflammatory, analgesic and antipyretic agents. The emphasis is on the action of nimesulide in relation to its therapeutic and side effects in comparison with other established NSAIDs, including the new class of Coxibs.
Natural occurrence and biological activities of quinoline derivatives
Provides a comprehensive overview of quinoline derivatives, focusing on their chemical structure, biological activities, and therapeutic benefits. It delves into the natural sources of these derivatives, covering their isolation, characterization, and potential therapeutic applications, particularly in areas such as anti-cancer, anti-inflammatory, antimicrobial, and antimalarial activity. With its emphasis on providing valuable reference material, this book is an indispensable resource for researchers, educators, and professionals in the fields of chemistry, biology, pharmacology, and drug discovery.
Medicinal compounds in modern healthcare : From tradition to innovation
Reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.
Inflammation and natural products ; 1st ed.
Brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes.
Ibuprofen : Pharmacology, Therapeutics and Side Effects
Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions. Over the past 40 years, ibuprofen has been proven to be as safe or even safer and also as effective as the established non-steroidal anti-inflammatory drugs (NSAIDs) and the coxibs. This well-written book reviews the pharmacology, clinical uses and the various adverse effects of Ibuprofen, the disposition and unique modes of action in relation to clinical effects of the drug as well as various formulations. The use of combinations with other drugs (e.g. paracetamol, codeine, caffeine) are critically assessed and the impact of natural products and Chinese Medicines on the safety of ibuprofen.
Handbook of Atopic Eczema
This second edition comprises the state of the art in pathophysiology, clinical medicine and therapeutic management. It demonstrates that there is no simple "miracle" cream, pill or diet for this disease, but that a disturbed barrier function can only be repaired by adequate and individualized skin care and it shows how unspecific anti-inflammatory treatment has to be individually tailored according to body area affected, patient age and acuity of skin lesions.
Gene Therapy of Autoimmune Disease
Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Gastric ulcers the cases and treatment
A gastric ulcer also known as stomach ulcer is an excoriated area of stomach caused principally by the digestive action of gastric juice Secretion in many ways the most common reasons are the taking non steroid anti-inflammatory drugs (NSAID) or an infection with Helicobacter pylori bacteria. It used to be Thought that stress or certain foods or drinking alcohol and smoking tobacco might cause stomach ulcer but in less cases. stomach ulcer can affect people of any age, including children, but mostly occur in people aged 50 or over. the common symptom is the pain in stomach and nausea with or without vomiting. the diagnosis through endoscopy is the best method to be sure about ulcer. the treatment of ulcer according to the reasons of ulcer is caused bacteria or not gastric ulcer It occurs in 80% of cases with the level of curvature The little one, especially the angle and antra, and effect men and women are the same.
Flavonoids as nutraceuticals
Flavonoids are well-known plant metabolites that have extraordinary properties that can be used for treating health issues. The pharmaceutical importance of flavonoids is due to their anti-depressant, anti-viral, anti-inflammatory, and antioxidant capacities. They are also of great importance when it comes to neuroprotection, cardiovascular disorders, and many types of cancer. Flavonoids are also easily available and produce less harmful side effects than some conventional therapeutics. This new volume examines the growing use of flavonoids for prevention and treatment of diseases and discusses their beneficial mechanisms. Chapters in the volume address diverse uses as anti-aging tools, as anti-inflammatory agents, for treating pregnancy-induced disorders, as a promising tool to combat infection of Covid-19, etc. The book explores their specific therapeutic antiviral potentials, the gene expression by flavonoids, and the role of flavonoids in agriculture.
Evaluation of the use of medicine plants in cancer treatment
Turmeric (Curcuma longa) and ginger (Zingiber officinale) have been widely studied for their potential anticancer effects, primarily due to the bioactive compounds curcumin and gingerol. Both compounds exhibit significant therapeutic properties, including anti-inflammatory, antioxidant, pro-apoptotic, and anti-angiogenic activities, which target key pathways implicated in cancer progression, such as NF-κB, STAT-3, and mTOR. Through these mechanisms, curcumin and gingerol inhibit tumor growth, reduce metastasis, and enhance the efficacy of conventional cancer treatments.
ECZEMA (Atopic Dermatitis)
Atopic dermatitis (eczema) is a condition that makes your skin red and itchy. It's common in children but can occur at any age. Atopic dermatitis is long lasting (chronic) and tends to flare periodically. It may be accompanied by asthma or hay fever. No cure has been found for atopic dermatitis, Certain substances or conditions called trigger factors can cause eczema to flare-up: Irritants such as soaps and detergents, wool, skin infections, dry skin, low humidity, heat, sweating or emotional stress. Allergens such as dust mites, pollen, moulds, or foods.and the treatment for the condition aims to heal the affected skin and prevent flares of symptoms.Topical medications (typically, steroids or other anti-inflammatory medications, and found a correlation between eczema and the Quality of life, Recently some study have done to study the relation with COVID-19.
Drug repurposing : A new fashion for a new hope
The repurposing of drugs is becoming increasingly attractive as it avoids the long process and cost implications associated with bringing a novel drug to market i.e., drug repurposing is cost effective and time saving. This study will discuss the repositioning of several drugs that belong to different pharmaceutical classifications such as antimicrobials (itraconazole and fluoroquinolones), anti-diabetic agents (metformin and sodium glucose co-transporter 2 inhibitors), cardiovascular drugs (β-blockers and digoxin), anticonvulsants (topiramate), immunosuppressants (sirolimus), non-steroidal anti-inflammatory drugs (NSAIDs e.g., COX inhibitors), and cholesterol lowering drugs (statins).
Diabetes meal planning nutrition For dummies
Offers you a holistic approach to living your best life with diabetes. Optimize your diet and plan delicious meals that will empower you to take control, improve your health, prevent, and even reverse diabetes. Written by an award-winning chef and renowned doctor who are both experts in the field of nutrition, this book helps you understand what defines healthful eating for diabetes, its crucial role to long term health, and how meal planning is a key to successful diabetes management. Learn how to receive all the nutrients necessary for glucose control while managing Type 1 or Type 2 diabetes and maintaining ideal weight. Discover how to supercharge your diet and protect yourself from the complications associated with diabetes with anti-inflammatory and antioxidant-rich foods.
Current Drug Synthesis
Delivers an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as well as the cutting-edge science involved in their synthesis. The book demystifies the process of modern drug discovery for both industry practitioners and students, while capturing the state-of-the-art techniques used to discover some of the most impactful medicines on the market today. Covering six different disease areas – including infectious disease, cancer, cardiovascular and metabolic disease, the central nervous system, anti-inflammatory disease, and a miscellaneous section – the book explores 18 different drugs before concluding with chapters on computational drug discovery and peptide drugs.
Curcumin : clinical uses, health effects and potential complications
Curcumin is a natural product with polyphenolic structure. It is used in therapeutic remedies alone or in combination with other natural substances. Many researchers are investigating it because of its biological activities such as: anti-inflammatory, anti-cancer, anti-protozoal, anti-viral, anti-bacterial and has been found to be effective for treatment of Alzheimer, depression, headaches, fibromyalgia, leprosy, fever, menstrual problems, water retention, worms and kidney problems etc. It is an active ingredient in dietary spice, turmeric. It has reactive functional groups: a diketone moiety and two phenolic groups. Despite its unique biological activities, it suffers from some shortcomings which include: gastrointestinal problems, poor bioavailability due to its poor absorption, short half-life, poor solubility in aqueous solutions, rapid systemic elimination and antithrombotic activity which can interfere with blood clotting. The first chapter of this book reviews the different delivery systems used for incorporation of curcumin and its derivatives, release kinetics and up to date in vivo results. Chapter two discusses curcumin nano and microencapsulation and its implications on clinical uses.
CRP and the relation with heart disease
Cardiovascular diseases are the leading causes of mortality and morbidity in industrialized and developing countries. Many efforts have been undertaken during the last decades to identify environmental, behavioral and genetic factors modulating the risk of cardiovascular diseases.It will explain the role of CRP - an acute-phase protein- as indicator of potential cardiovascular disease as well as a predictor of the risk for heart disease and future heart attack
Consequences of Unawareness in Usage of Some Medicines and Diet Routine
In the short term, imbalanced nutrition can contribute to stress, tiredness and our capacity to work, and over time, it can contribute to the risk of developing some illnesses and other health problems such as: being overweight or obese, tooth decay, high blood pressure. Such habits cause considerable damage to human existence such as loss of potential and motivation, premature aging of the human body and the acquisition of diseases of various kinds. Such habits include the consumption of the following substances and medications which we will focus on in our research project in order to contribute to the public health awareness and to provide people with the best way to eat, on the other hand as an effect, pharmacologist we will also include the possible therapy of such diseases. However, with their side and some other commune drugs we are used to take on daily terms or very often but it may have a toxic side effect.
Chemokine biology : Basic research and clinical application ; Vol.1 : Immunobiology of chemokines
The discovery of interleukin-8 close to 20 years ago initiated a new field of research touching on many aspects of immunology and inflammation. Interleukin-8 is just one member of a large class of structurally related chemoattractant proteins, known as chemokines. Chemokines are involved in the traffic control of leukocytes, which bear the corresponding chemokine receptors on their surfaces. Today, it is clear that chemokines affect all aspects of immunology and even many unrelated fields, such as tissue development and tumor cell metastasis. Their fundamental contributions to chronic inflammatory diseases make them a principal target for the development of novel, anti-inflammatory therapeutics.
Chemistry of Biologically Potent Natural Products and Synthetic Compounds
Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.
