الصفحة 1
الصفحة 1
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
Molecular Neurosurgery with Targeted Toxins
Focuses on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.
Guyton and Hall textbook of medical physiology
Employs a distinctive format to ensure maximum learning and retention of complex concepts. A larger font size emphasizes core information, while supporting information, including clinical examples, are detailed in smaller font and highlighted in pale blue - making it easy to quickly skim the essential text or pursue more in-depth study. This two-tone approach, along with other outstanding features, makes this bestselling text a favorite of students worldwide. Offers a clinically oriented perspective written with the clinical and preclinical student in mind, bridging basic physiology with pathophysiology. Focuses on core material and how the body maintains homeostasis to remain healthy, emphasizing the important principles that will aid in later clinical decision making. Presents information in short chapters using a concise, readable voice that facilitates learning and retention. Contains more than 1,200 full-color drawings and diagrams - all carefully crafted to make physiology easier to understand. Features expanded clinical coverage including obesity, metabolic and cardiovascular disorders, Alzheimer's disease, and other degenerative diseases.
Fullerene and Alzheimer disease
Patients have suffered for a long time from Alzheimer's disease. The presence of some obstacles in treatment, which prompted us to talk in this research on one of the modern treatments for this disease, which is fullerene. The focus was in some detail on its structure and characteristics, in addition to its applications. We especially mention its application in the treatment of Alzheimer's. This was a new step in the world of medicine and pharmacy.
Exosomes based drug delivery strategies for brain disorders
Provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.
Évaluation des troubles neuropsychologiques en vie quotidienne = Assessment of neuropsychological disorders in daily life
Neurological diseases such as stroke, head trauma, Alzheimer's disease pose a public health problem. They affect all ages, from children to the elderly. They affect the possibilities of autonomy in daily life, the possibilities of social or professional integration. In these pathologies, neuropsychological disorders: disorders of language, memory, attention, etc., are the source of crucial difficulties. Cognitive tests performed by psychologists are essential for their diagnosis, but do not on their own make it possible to prejudge the difficulties encountered by people in their everyday life. This book presents an original approach to neuropsychological disorders, by describing specific assessments describing difficulties in daily life, in order to better understand them and to quantify their impact. The second part of the book develops the consequences in clinical practice in particular populations - children and the elderly - or the social objective of the evaluation, in particular school integration, professional integration and driving. Finally, the relevance of these assessments in the context of recent laws on disabled people as well as the development of compensation for bodily injury after an accident are also discussed.
COVID-19 in Alzheimer's disease and dementia
COVID-19 in Alzheimer’s Disease and Dementia crucially summarizes the current status of the coronavirus in patients suffering from these conditions, describing why they are a common cause of morbidity among those with COVID-19. The first section includes chapters that provide a general description of COVID-19, including SARS-CoV-2 structure, function, and biology, and its impact on the elderly with chronic conditions include hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases. Also discussed are effects of the virus on the immune system. The second section shifts to the impact of COVID-19 on those with dementia or Alzheimer’s disease, with special emphasis on age, gender, ethnic background, and lifestyle.
Chamomile & insulin nasal spray in the treatment of Alzheimer's disease
Chamomile is one of the most widely used herbs in Western countries, in the present study, we assessed the effect of chamomile combined with insulin on the learning and memory impairments (Alzheimer's disease) induced by scopolamine. The cognition-enhancing effect of chamomile & insulin was investigated using the Y-maze test. Drug-induced amnesia was induced by treating animals with scopolamine. Mix solution administration intranasally reversed scopolamine induced cognitive impairments in mice by the Y-maze test. Moreover, results suggest that the combination of both chamomile and insulin may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via inhibitory effects in vivo on the release of several pro-inflammatory mediators and as a co-absorbent.
Alzheimer's disease : Peptide vaccine and immunotherapy
Peptide vaccines and immunotherapies against aggregating proteins involved in the pathogenesis and progression of Alzheimer's disease (AD) the ẞ-amyloid peptide (Aẞ) and tau are promising therapeutic avenues against AD. Two decades of effort has led to the controversial United States Food and Drug Administration (FDA) approval of the monoclonal antibody Aducamumab (Aduhelm), which has subsequentially sparked the revival and expedited review of promising monoclonal antibody immunotherapies that target Aẞ.
Alzheimer's Disease
Alzheimer is a disease which has not a cure yet, and about 10% of the population worldwide will suffer from it. However younger people may also develop this disease mainly at 45 years old mainly women who has double the rate of incidence since 1 if five women will certainly develop it. Therefore the goal of our research is to study first of all the history of such popular disease and its risk factors and current therapies or iagnostic tools and more important we will introduce a test which was discovered few months ago to predict the risk of developing Alzheimer few decades before it occurs and we will apply it in our laboratories in Syria as well. Beside this preventive test we will add also a very important diet to follow up by people who has a family history.
Alzheimer’s and new horizon
Alzheimer's disease (AD) is characterized by progressive loss of memory and other cognitive functions. This study aims to discuss Alzheimer's disease (AD) and its increasing incidence and related huge fund to take care of such patients and will understand the pathophysiology in order to successfully fight this enigmatic illness and the goal of is the treatment for individuals with AD. Our study will also focus on the mutualistic relationship between AD and SARS- COV-2 infection and its correlation with cancer will be also discussed...
