الصفحة 9
الصفحة 9
Deep Brain Stimulation in Neurological and Psychiatric Disorders
Deep Brain Stimulation in Neurological and Psychiatric Disorders discusses today’s most current and cutting-edge applications of DBS. Initially used to treat Parkinson’s disease and essential tremor, DBS now has new clinical indications, new anatomic targets, and new technologies that enable an expanded role for DBS in the treatment of other movement disorders.
Data mining with computational intelligence
Finding information hidden in data is as theoretically difficult as it is practically important. With the objective of discovering unknown patterns from data, the methodologies of data mining were derived Wang and Fu present in detail the state of the art on how to utilize fuzzy neural networks, multilayer perceptron neural networks, radial basis function neural networks, genetic algorithms, and support vector machines in such applications. They focus on three main data mining tasks: data dimensionality reduction, classification, and rule extraction. The book is targeted at researchers in both academia and industry, while graduate students and developers of data mining systems will also profit from the detailed algorithmic descriptions.
Data driven : Harnessing data and AI to reinvent customer engagement
Data Driven will show you how to: Target and delight your customers with unprecedented accuracy and success, Bring customers closer to your brand and inspire them to engage, purchase, and remain loyal, Capture, organize, and analyze data from every source and activate it across every channel, Create a data-powered marketing strategy that can be customized for any audience, Serve individual consumers with highly personalized interactions, Deliver better customer service for the best customer experience, Improve your products and optimize your operating systems, Use AI and IoT to predict the future direction of markets. Also you’ll discover the three principles for building a successful data strategy and the five sources of data-driven power.
Data center networking : Network topologies and traffic management in large-scale data centers
Provides a comprehensive reference in large data center networking. It first summarizes the developing trend of DCNs, and reports four novel DCNs, including a switch-centric DCN, a modular DCN, a wireless DCN, and a hybrid DCN. Furthermore another important factor in DCN targets at managing and optimizing the network activity at the level of transfers to aggregate correlated data flows and thus directly to lower down the network traffic resulting from such data transfers. In particular, the book reports the in-network aggregation of incast transfer, shuffle transfer, uncertain incast transfer, and the cooperative scheduling of uncertain multicast transfer.
Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases.This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".
Cyclized Helical Peptides : Synthesis, Properties and Therapeutic Applications
Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity
Crop Biosecurity : Assuring our Global Food Supply
Prevention and preparedness are the two basic approaches to maximize food security against any sort of tampering, whether natural, inadvertent or intentional. The NATO funded project “Tools for crop biosecurity” was designed to strengthen the cooperation among U.S., Europe and Israel in the field of crop biosecurity and to generate awareness on how the psychological, economic and cultural consequences of crop bioterrorism, especially attacks on soft targets such as crop seeds, could have a disproportionate adverse effect on Mediterranean agriculture and, more generally, on society.This book illustrates the achievements of the project originated from the workshops organized during the project itself taking in consideration main microbiological threads posed to crops, the tools to recognize and to control them, the needs for international cooperation and research funds to create networks which can face emerging risks for agriculture.
Critical issues in head and neck oncology : Key concepts from the eighth THNO meeting
Reviews the state-of-the-art knowledge with emphasis on multidisciplinary decision and management of head and neck cancer. The book provides significant detail on a wide range of topics including: the role of new targets for treatment, immunotherapy, resistance mechanisms, standardizing molecular profiling programs, and new methods to guide therapeutic approaches.
Craniofacial pain : Temporomandibular disorders and beyond
Provides a broad, evidence based resource for all clinicians who encounter challenging patients suffering from TMDs. Common causes of craniofacial and myofascial pain of the head and neck, TMD treatment paradigms, and associated symptoms are explained. Background information on TMJ Anatomy, TMD Epidemiology and Pathology is given and advanced topics like therapeutic target and movement disorders and TMD are discussed.
Costs of air pollution control : Analyses of emission control options for ozone abatement strategies
This work derives strategies for developing useful EU policies aimed at the control of air pollutants in Europe, especially ground-level ozone. The author starts with the air-pollution status quo in the late 1990s, placing further impacts of photooxidant concentrations into perspective. Emission sources are then analysed in detail, and a likely scenario for a business-as-usual development in emissions is proposed. From the cost-benefit perspective, it is shown that a holistic, integrated evaluation of all air pollutants and their effects results in a full accounting that reflects synergies and hidden benefits. The modelling scheme identifies emission targets needed to achieve compliance with EU thresholds, and calculations reveal the need to review established ozone thresholds and emission limits, even after discounting the positive effects of including central and eastern European nations.
Cost-Efficient Design
This is the first English edition of an established work on cost-driven product design and development. It offers tried and tested methods for understanding, influencing and reducing product costs. The methodology and organization of cost management, as well as the effects on each type of cost are described. Using this knowledge the product developer can assume responsibility for costs. The numerous examples and detailed derivation of results provide the practical user with problem solutions and hints. Methods such as Target Costing and Simultaneous Engineering are discribed. Thus the book will also help the specialist who does not have the overview of the complex interrelationships in the enterprise. The work is also suited for students, as well as for practicing engineers.
Corporate Control and Enterprise Reform in China : An Econometric Analysis of Block Share Trades
This study sheds light on the efficiency of corporate control allocation in Chinese listed firms. Using a panel data set for the period 1996 to 2006, it examines the frequency, causes and consequences of changes in corporate control. The results indicate that poorly performing firms are the predominant targets of control changes; shareholder and creditor control generally act as a complement for changes in control. Following the change in ownership there is a substantial amount of corporate restructuring and an improvement in operating performance. Significant differences in these dimensions emerge, however, between State and private transfers of control. The findings not only provide insights into the motives and constraints of the key players involved in governance practices in China; but they also contain useful implications for other emerging markets around the world that have weak legal systems and weak property rights protection.
Coronavirus therapeutics ; Vol. I : Basic science and therapy development
Provides the most comprehensive review on contemporary knowledge on the origin and structural biology and molecular aspects of Coronaviruses. This also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated.
Contemporary Accounts in Drug Discovery and Development
Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also—and perhaps more importantly—on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field.
Congenital Diseases and the Environment
"In recent years, increasing attention and resources have been brought to bear on the relationship between the environment and congenital diseases. These diseases were previously thought to be mostly due to genetic causes. Even though the importance of genes as factors in causation is accepted, environmental factors seem to be implicated just as strongly. This book explores some further concepts that have arisen from more recent perceptions of environmental effects and their possible interactions with living systems. Discussion and presentation of old and novel ideas is targeted at developing a more holistic and united perception of the interaction between congenital diseases and the environment. Amongst the topics discussed are: -effects of prenatal exposure to toxic chemicals -intra-uterine exposure to drugs -effects of endocrine disrupters -environmental risk and sex ratio in newborns -surveillance of environmental impact-research and policy."
Concepts in pharmaceutical biotechnology and drug development
Provides comprehensive coverage of the development of new pharmaceuticals and the enhancement of existing ones. It offers a comprehensive understanding of pharmaceutical biotechnology, including its underlying principles and practical applications from an industrial standpoint. While introducing the roles and applications of biotechnology in drug design and development, the book describes how developments in other fields, like genomics, proteomics, and high-throughput screening, have facilitated the discovery of novel therapeutic targets and drug development methods. It included concepts that are essential to biotechnology and apply to protein therapies. And provides a thorough overview of the ways in which biotechnology influences drug development, production, and regulation, and is a valuable resource for those seeking to enhance their understanding in this area.
Computer Vision Metrics : Survey, Taxonomy, and Analysis
Computer Vision Metrics provides an extensive survey and analysis of over 100 current and historical feature description and machine vision methods, with a detailed taxonomy for local, regional and global features. This book provides necessary background to develop intuition about why interest point detectors and feature descriptors actually work, how they are designed, with observations about tuning the methods for achieving robustness and invariance targets for specific applications. The survey is broader than it is deep, with over 540 references provided to dig deeper. The taxonomy includes search methods, spectra components, descriptor representation, shape, distance functions, accuracy, efficiency, robustness and invariance attributes, and more.
Computer recognition systems 2
Computer recognition systems are nowadays one of the most promising directions in artificial intelligence. This book presents actual comprehensive study of this field. It contains a collection of over one hundred carefully selected articles contributed by experts of pattern recognition. It reports on current research with respect to both methodology and applications. In particular, it includes the following sections: Features, learning and classifiers / Image processing and computer vision / Speech and word recognition / Medical applications / Various applications. This book is a great reference tool for scientists who deal with the problems of designing computer pattern recognition systems. Its target readers can be the as well researchers as students of computer science, artificial intelligence or robotics.
Computational drug discovery and design
Provides new and updated methods and techniques for identification of drug target, binding sites prediction, high- throughput virtual screening, lead discovery and optimization, conformational sampling, prediction of pharmacokinetic properties using computer-based methodologies. Chapters also focus on the application of the latest artificial intelligence technologies for computer aided drug discovery.
Cold War Civil Defence in Western Europe : Sociotechnical Imaginaries of Survival and Preparedness
This edited collection brings together established and new perspectives on Cold War civil defence in Western Europe within a common analytical framework that also facilitates comparative and transnational dimensions. The current interest in creating disaster-resilient societies demands new histories of civil defence. Historical contextualization is essential in order to understand what is at stake in preparing, devising, and implementing forms of preparedness, protection, and security that are specifically targeted at societies and citizens. Applying the concept of sociotechnical imaginaries to civil defence history, the chapters of this volume cover a range of new themes, from technology and materiality to media, memory, and everyday experience.
