الصفحة 9
الصفحة 9
Sodium-glucose cotransporter-2 (SGLT2) inhibitors in heart failure : mechanisms and clinical applications : a machine-generated literature overview
Delves into the development and therapeutic potential of Sodium-glucose Cotransporter-2 (SGLT2) inhibitors for the treatment of diabetes and cardiovascular diseases. It explores their mechanism of action, cardiovascular benefits, and role in primary and secondary protection from renal and cardiovascular diseases. The book also highlights their emerging opportunities in the management of myocardial infarction, diabetic cardiomyopathy, and congestive heart failure. It provides a comprehensive review of preclinical and clinical information on the cardiovascular advantages of SGLT2 inhibitors. Additionally, the book explores selective drugs and their effects on cardiovascular events, mortality, and safety outcomes in individuals with type 2 diabetes.
Socket preservation after extraction using bone graft and resorbable membrane
This review supported by 2 clinical cases explores the biological mechanisms of bone formation, types of grafting materials—especially xenografts—and key surgical principles that ensure successful outcomes.
Socioeconomics of Agriculture
Applies for the first time emerging concepts of socioeconomics to analyse an economic sector, namely agriculture. It considers the rational choices of all actors in the system (just as agricultural economists do) and their cultural preferences and constraints (just as rural sociologists do). Socioeconomic concepts are subsequently used to structure agricultural issues with regard to the three governance mechanisms (hierarchy, markets, and cooperation), and different agricultural systems are presented and compared. The book will be of interest to social scientists with various backgrounds, and seeks to break down the barriers of single-disciplinary thinking.
Socioeconomic and Environmental Implications of Agricultural Residue Burning : A Case Study of Punjab, India
Discusses the important issue of the socioeconomic and environmental impacts of agricultural residue burning, common in agricultural practices in many parts of the world. In particular, it focuses on the pollution caused by rice residue burning using primary survey data from Punjab, India. It discusses emerging solutions to agricultural waste burning that are cost-effective in terms of both money and time. The burning of agricultural residue causes severe pollution in land, water and air and contributes to increased ozone levels and climate change in the long term. However, appropriate assessments have not been undertaken so far to demonstrate the relevant impact of agriculture-based pollution, especially residue burning. This book addresses this gap in the literature.
Social Computing with Artificial Intelligence
Provides a comprehensive introduction to the application of artificial intelligence in social computing, from fundamental data processing to advanced social network computing. To broaden readers’ understanding of the topics addressed, it includes extensive data and a large number of charts and references, covering theories, techniques and applications. It particularly focuses on data collection, data mining, artificial intelligence algorithms in social computing, and several key applications of social computing application, and also discusses network propagation mechanisms and dynamic analysis, which provide useful insights into how information is disseminated in online social networks. This book is intended for readers with a basic knowledge of advanced mathematics and computer science.
Snow Sports Trauma and Safety ; Conference Proceedings of the International Society for Skiing Safety : 21st Vol.
Covers the latest in snow sport epidemiology, snow sport injuries and treatment, and biomechanical/mechanical engineering related to snow sports injuries (mechanisms of injury, injury prevention by equipment design, injury prevention by design of resort features, and more). It brings together a collection of papers from the International Congress on Ski Trauma and Safety (the biennal meeting of the International Society for Skiing Safety) and presents the latest research on the effectiveness of winter sports equipment, the behavior of winter sports participants, and the epidemiology and biomechanics of winter sports injuries. This is an ideal book for researchers and professionals working in the field of sports medicine and safety.
Snake and spider toxins : Methods and protocols
Explores techniques and protocols, across various biological disciplines, used to study snake and spider peptide toxins. The chapters in this book are organized into four parts and cover topics such as the use of toxins in drug development; analysis of bioactivity of complex mixtures like venom; extraction of venom glands and the production of toxins; characterization of toxins from the RNA level to the peptide structure; and the determination of the toxin’s biological function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Snake and Spider Toxins: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.
Small RNAs : Analysis and Regulatory Functions
In recent years Molecular Biology has experienced an unprecedented revolution by the discovery of functional small RNAs. The number of cellular processes in which non-coding RNAs are involved is growing rapidly and include gene regulation on the transcriptional, post-transcriptional and translational level. To complicate matters, these processes seem to be strongly interconnected on the one hand, and diverse among different organisms on the other. This volume describes strategies for the discovery and validation of small RNAs and provides a snapshot of our current understanding of the different mechanisms triggered by small RNAs.
Smad Signal Transduction : Smads in Proliferation, Differentiation and Disease
Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided. This book will be of particular interest to basic and applied biomedical researchers (students, post-docs or group leaders) with desire to understand the principles of cell-cell communication and mechanisms by which signaling pathways and gene programs control cell proliferation and differentiation, and how this knowledge may come to be applied in the clinic.
Sliding Filament Mechanism in Muscle Contraction : Fifity Years of Research
Sliding Filament Mechanism in Muscle Contraction: Fifty Years of Research covers the history of the sliding filament mechanism in muscle contraction from its discovery in 1954 by H.E. Huxley through and including modern day research. Chapters include topics in dynamic X-ray diffraction, electron microscopy, muscle mechanisms, in-vitro motility assay, cardiac versus smooth muscle, motile systems, and much more.
Skin whitening
Provides insight into the mechanisms involved in melanin synthesis pathway as well as the most common pigmentation disorders, then it asses in details the diverse approaches to achieve skin whitening activity with the available ingredients. And delve into the different new approaches for encapsulation and delivery of the active ingredients using nanomaterials and further into using emerging technologies to achieve the desired effects for the patients
Skeletal Muscle Repair and Regeneration
Skeletal muscle is the most abundant tissue of our body. Apart from its essential role in locomotion, it is also the body’s main store of carbohydrate and protein as well as being one of the principal generators of heat. Its proper maintenance and function are, therefore, essential. A severe acute loss of muscle function is potentially lethal and the debilitating effects of chronic decline in mobility are commonplace experience, so repair and maintenance of the tissue must by both rapid and effective. Since the middle of the last century we have progressively built up a comprehensive descriptive model of the allied mechanisms that maintain our muscles at a size and strength appropriate to the functional demands upon them and that rapidly repair damaged muscles. This volume is an assemblage of the collective experience from the pick of major research groups investigating these aspects of muscle cell biology.
Skeletal Muscle Plasticity in Health and Disease : From Genes to Whole Muscle
Aims to provide a systematic updating of the available knowledge on molecular and cellular mechanisms, as well as on changes at whole muscle level. The book means to be a guide and a help for people who enter the field as PhD or medical students, but is also a tool for refreshing and updating knowledge for people already active in the field in basic sciences as well as in applied disciplines such as neurology, sports science and rehabilitation.
Sjögren's Syndrome and Oral Health : Disease Characteristics and Management of Oral Manifestations
Provides a thorough update on Sjögren’s syndrome (SS) and its adverse impacts on oral health. The opening section focuses on the clinical and laboratory characteristics of SS and its current management. The final section details important advances in SS diagnosis and therapy. The differential diagnoses of recurrent glandular swelling, glandular irrigation and sialendoscopy, and salivary gland ultrasound for SS in children are explained, along with the pharmacological management for SS, clinical care for dry eyes, and gene therapy.
Sixth IUTAM Symposium on Laminar-Turbulent Transition ; Proceedings of the Sixth IUTAM Symposium on Laminar-Turbulent Transition, Bangalore, India, 2004
The sixth IUTAM meeting in the series included seven invited lectures, fifty oral presentations and eight posters. During the course of the symposium, the following became evident. The area of laminar-turbulent transition has progressed considerably since 1999. Better theoretical tools, for handling nonlinearities as well as transient behaviour are now available.
Single-Use Technology in Biopharmaceutical Manufacture
This authoritative guide contains the basic knowledge and information about disposable equipment. The author also discusses biopharmaceuticals’ applications through the lens of case studies that clearly illustrate the role of manufacturing, quality assurance, and environmental influences. This updated second edition revises existing information with recent developments that have taken place since the first edition was published. The book also presents the latest advances in the field of single-use technology and explores topics including applying single-use devices for microorganisms, human mesenchymal stem cells, and T-cells.
Simulation and Assessment of Chemical Processes in a Multiphase Environment
Reviews the current state of knowledge on the chemical and physical processes occurring in the environmental media (i) the atmosphere, (ii) the aqueous phase and (iii) soil and identifies the strengths and weaknesses of the chemical mechanisms (both explicit and condensed) currently available to simulate the multimedia environmental chemistry of volatile organic compounds (VOCs) and particulate matter in these media.
Signaling Pathways in Liver Diseases
Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.
Shh and Gli Signalling in Development
In this book, the chapters span vertebrate organisms from zebrafish to humans and cover development of the multiple organ systems in which the Shh signalling pathway is crucial for normal development. There are chap ters on the development of the central nervous system, skeletal struc tures, visceral organs, prostate, lung, immune system and the structures of the human face.
SH2 domains: Functional modules and evolving tools in biology
Looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts. Part One presents methodology aimed at determining the structures and dynamics of SH2 domains and their complexes with phosphopeptides. Part Two discusses techniques to understand and predict interactions of SH2 domains by measuring or calculating their affinity to phosphopeptides. Part Three focuses on inhibitors of SH2 domains that lead the way for chemical tool development and drug discovery. Part Four describes how to evolve and engineer SH2 domains with specific binding properties, and Part Five explores how to measure the regulation of protein tyrosine phosphatase activity through allosteric binding of peptides to SH2 domains and condensation. Chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, SH2 Domains: Functional Modules and Evolving Tools in Biology is a valuable resource for researchers, working in the biophysical and biochemical field, who want to learn more about this exciting and versatile class of regulatory and signaling domains.
