الصفحة 7
الصفحة 7
Feldman and Pike's vitamin D; Vol. 1 : Biochemistry, physiology and diagnostics
Presents a comprehensive review of the multi-faceted actions of vitamin D relating both to skeletal and extra-skeletal action. Researchers from all areas of vitamin D will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic insights into the mechanisms of disease.
Fatty acids
Fatty acid metabolism, including the de novo synthesis, uptake, oxidation, and derivation of fatty acids, plays several important roles at cellular and organ levels. Recent studies have identified characteristic changes in fatty acid metabolism in idiopathic pulmonary fibrosis (IPF) lungs, which implicates its dysregulation in the pathogenesis of this disorder. Here, we review the evidence for how fatty acid metabolism contributes to the development of pulmonary fibrosis, focusing on the profibrotic processes associated with specific types of lung cells, including epithelial cells, macrophages, and fibroblasts. We also summarize the potential therapeutics that target this metabolic pathway in treating IPF.
Expert C++/CLI : .NET for Visual C++ Programmers
C++/CLI is Microsofts latest extension to C++ that targets the heart of .NET 2.0, the common language runtime. Expert Visual C++/CLI is written by visual C++ MVP Marcus Heege, who examines the core of the C++/CLI language. He explains both how the language elements work and how Microsoft intends them to be used.
Evaluation of the use of medicine plants in cancer treatment
Turmeric (Curcuma longa) and ginger (Zingiber officinale) have been widely studied for their potential anticancer effects, primarily due to the bioactive compounds curcumin and gingerol. Both compounds exhibit significant therapeutic properties, including anti-inflammatory, antioxidant, pro-apoptotic, and anti-angiogenic activities, which target key pathways implicated in cancer progression, such as NF-κB, STAT-3, and mTOR. Through these mechanisms, curcumin and gingerol inhibit tumor growth, reduce metastasis, and enhance the efficacy of conventional cancer treatments.
Evaluating the Employment Effects of Job Creation Schemes in Germany
This book analyses the employment effects of job creation schemes for the participating individuals in Germany. Programmes provide subsidised jobs that are additional in nature and of value for society to hard-to-place individuals. International evidence on the effectiveness suggests that programmes should be targeted to the needs of the unemployed and should be offered early in the unemployment spell. Both questions are studied for job creation schemes in Germany. In the empirical analysis, propensity score matching methods extended to the dynamic setting are applied to administrative data of the Federal Employment Agency.
Essential pharmaceutics
Essential Pharmaceutics is suited to this modern teaching style, and is the first book of its kind to provide the resources and skills needed for successful implementation of an active learning pharmaceutics course.This text offers a format that is specifically suited for integration in an active learning, team-based classroom setting
Essential oils for dental health : A holistic guide to oral care and treatment
Explores the benefits of and best methods of use for well-known dental care oils such as peppermint, tea-tree, and clove as well as the lesser known oral benefits of oils like cinnamon, manuka, and oregano. Offers many simple practical techniques to easily incorporate essential oils into your daily oral care routine. Includes recommended oil mixtures targeted to alleviate specific dental and oral ailments, such as periodontitis, oral herpes, ulcers, teething, dry mouth, bad breath, teeth grinding, and toothache.
Equitable research partnerships : A global code of conduct to counter ethics dumping
This book offers insights into the development of the ground-breaking Global Code of Conduct for Research in Resource-Poor Settings (GCC) and the San Code of Research Ethics. Using a new, intuitive moral framework predicated on fairness, respect, care and honesty, both codes target ethics dumping – the export of unethical research practices from a high-income setting to a lower- or middle-income setting. The book is a rich resource of information and argument for any research stakeholder who opposes double standards in research. It will be indispensable for applicants to European Union framework programmes, as the GCC is now a mandatory reference document for EU funding.
Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Enzymes and drugs
Enzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs. Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting. Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances.
Entry Inhibitors in HIV Therapy
The introductory chapters of this book present an overview of entry inhibitors, review current knowledge of how Env mediates entry, and discuss the challenge of genetic diversity in this region of the viral genome. Subsequent chapters feature current information on individual classes of entry inhibitors that target each step of the virus entry pathway, from attachment to membrane fusion. There is an emphasis on the complex determinants of entry inhibitor susceptibility, resistance mechanisms, the need for clinical phenotyping, and how these issues create new challenges for antiretroviral therapy. Encouraging pre-clinical studies of entry inhibitors as microbicidesare also discussed. The final chapters highlight the current status of entry inhibitors in clinical studies, the major milestone achieved with FDA approval of enfuvirtide, and review drug development, past and present.
Endoscopic Anatomy of the Third Ventricle : Microsurgical and Endoscopic Approaches
In this atlas anatomical aspects important for combinations of microsurgical and endoscopic approaches are presented and illustrated. Modern imaging techniques are necessary for the three-dimensional orientation but do not show enough details for endoscopic interventions. The small visual fields need a combination of the depiction of fine details and of the three-dimensional presentation of large areas. Furthermore, problems with little known anatomical standard variants of the target areas may arise. Therefore, numerous common anatomical variants are demonstrated with reference to their impact for the surgical technique.
Encyclopedia of Molecular Pharmacology
It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Encyclopedia of Molecular Pharmacology
Covers all aspects of pharmacology, from the chemistry of drugs and the biochemistry of drug targets to the clinical application of drugs, with emphasis on molecular mechanisms. It also includes techniques for describing the effects of drugs and characterizing drug targets. With over 2,000 entries and 350 detailed essays by leading experts, this book is also an up-to-date and important reference for scientists in fields outside pharmacology, students, health care workers, teachers, physicians, and laypersons.
Encyclopedia of GIS "Geographical Information Sciences"
provides up-to-date information on emerging topics such as spatial big data, smart-phone GIS, urban computing and mobile recommender systems. It also expands the first edition’s rich set of GIS-related commercial and societal applications such as geo-targeting, geo-fencing and understanding climate changes, while enabling more comprehensive coverage of classical GIS topics such as map projections, global positioning systems and spatial cognition. The entries explain the key software, data sets and processes used by geographers and computational scientists. Additionally, the reference emphasizes the role of GIS in business and mobile intelligence. By offering more diversified GIS-related topics from theory and research than most of the other available literature, the authors equip newcomers to the field with principles as well as applications.
Enabling Technologies for Wireless E-Business
Kou and Yesha and their contributors provide comprehensive information on these technologies, including, for example, wireless security, mobile payment, location-based services, mobile data management, and RFID technologies. The presentation is targeted at students, lecturers, e-business developers, consultants, and business managers, and this book is an ideal introduction for both self-study and taught e-business classes or commercial training courses.
Enabling Sustainable Energy Transitions : Practices of legitimation and accountable governance
This book reframes sustainable energy transitions as being a matter of resolving accountability crises. It demonstrates how the empirical study of several practices of legitimation can analytically deconstruct energy transitions, and presents a typology of these practices to help determine whether energy transitions contribute to sustainability.
Embedded systems design : The ARTIST roadmap for research and development
Embedded systems now include a very large proportion of the advanced products designed in the world, spanning transport (avionics, space, automotive, trains), electrical and electronic appliances (cameras, toys, televisions, home appliances, audio systems, and cellular phones), process control (energy production and distribution, factory automation and optimization), telecommunications (satellites, mobile phones and telecom networks), and security (e-commerce, smart cards), etc. The extensive and increasing use of embedded systems and their integration in everyday products marks a significant evolution in information science and technology. We expect that within a short timeframe embedded systems will be a part of nearly all equipment designed or manufactured in Europe, the USA, and Asia. There is now a strategic shift in emphasis for embedded systems designers: from simply achieving feasibility, to achieving optimality. Optimal design of embedded systems means targeting a given market segment at the lowest cost and delivery time possible. Optimality implies seamless integration with the physical and electronic environment while respecting real-world constraints such as hard deadlines, reliability, availability, robustness, power consumption, and cost. In our view, optimality can only be achieved through the emergence of embedded systems as a discipline in its own right.
Eldercare Technology for Clinical Practitioners
Eldercare Technology: A Handbook for Practitioners addresses technologies targeted at the assessment, early detection and the mitigation of common geriatric conditions including decline in functional abilities, gait, mobility, sleep disturbance, vision impairment, hearing loss, falls, and cognitive decline.
Effective Functional Verification : Principles and Processes
Effective Functional Verification is organized into 4 parts. The first part contains 3 chapters designed appeal to newcomers and experienced people to the field. There is a survey of various verification methodologies and a discussion of them. The second part with 3 chapters is targeted towards people in management and higher up on the experience ladders. New verification engineers reading these chapters learn what is expected and how things work in verification. Some case studies are also presented with analysis of proposed improvements. The last two parts are the result of experience of several years. It goes into how to optimize a verification plan and an environment and how to get results effectively.
