الصفحة 69
الصفحة 69
Antiangiogenic Agents in Cancer Therapy
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Anthracycline Chemistry and Biology II : Mode of Action, Clinical Aspects and New Drugs
This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.
Antarctic ecosystems : Environmental contamination, climate change, and human impact
This volume provides an overview of climate change data, its effects on the structure and functioning of Antarctic ecosystems, and the occurrence and cycling of persistent contaminants. It discusses the unique physico-chemical characteristics of the Antarctic environment, ecophysiological adaptations of terrestrial and marine organisms, the transfer of contaminants in pelagic and neritic food chains and the possible consequences for animals at higher trophic levels.
Animal cell technology : Basic & applied aspects ; Proceedings of the 7th Annual Meeting of the Japanese Association for animal cell technology (JAACT), Nagoya, Japan, November 15-18, 2004
This book contains the proceedings of the 17th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT) that was held in Nagoya, Japan from November 15 to 18, 2004. This volume gives the readers a complete review of present state-of-the-art in Japan and other countries where this field is well advanced. The Proceedings will be useful for the cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers and other disciplines related to animal cell culture, working in either academic environments or in industries of biotechnology and pharmacy.
Anestetici locali in analgesia ostetrica : Il modello MLAC : dalla teoria alla pratica clinica = Local anesthetics in obstetric analgesia : The MLAC model : from theory to clinical practice
This monograph contains a detailed description of the MLAC method and its applications and an extensive and updated review of the most significant studies on the subject and their clinical implications. Studies that use the up-down sequential allocation method have made a significant contribution to clarifying numerous questions that the anesthetist asks himself every day in the delivery room and today rightly flank traditional studies representing, together with them, the primary source of updating and knowledge that are indispensable for good clinical practice based not only on experience but also on evidence and scientific rationale.
Andrology for the Clinician
Andrology for the Clinician consists of two parts: In Part One, the busy clinician can easily find the problem-orientated information he or she needs on such issues as * Male factor fertility problems * Male contraception * Male genital tract infection and tumours Part Two contains in-depth subject-orientated information and adds important scientific background information to the recommendations received in Part One. Several leading experts have contributed to this work, which has been extensively subedited by world-renowned editors to ensure a well-structured didactic design and homogeneous content.
Ancient monuments and modern identities : A critical history of archaeology in 19th and 20th century Greece
Sets out to examine the role of archaeology in the creation of ethnic, national and social identities in 19th and 20th century Greece. The essays included in this volume examine the development of interpretative and methodological principles guiding the recovery, protection and interpretation of material remains and their presentation to the public. The role of archaeology is examined alongside prevailing perceptions of the past, and is thereby situated in its political and ideological context. The book is organized chronologically and follows the changing attitudes to the past during the formation, expansion and consolidation of the Modern Greek State. The aim of this volume is to examine the premises of the archaeological discipline, and to apply reflection and critique to contemporary archaeological theory and practice.
Anatomy for dental students
Demonstrates and explains all the anatomy needed for a modern dentistry undergraduate course. This text covers developmental anatomy, the thorax, the central nervous system, and the head and neck with an emphasis on the practical application of anatomical knowledge.
Analyzing T cell responses : How to analyze cellular immune responses against tumor associated antigens
Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer
Analytical scientists in pharmaceutical product development : Task management and practical knowledge
Explains task management concepts and outlines practical knowledge to help pharmaceutical analytical scientists become productive and enhance their career. •Presents broad topics such as product development process, regulatory requirement, task and project management, innovation mindset, molecular recognition, separation science, degradation chemistry, and statistics. •Provokes thinking through figures, tables, and case studies to help understand how the various functions integrate and how analytical development can work efficiently and effectively by applying science and creativity in their work. •Discusses how to efficiently develop a fit-for-purpose HPLC method without screening dozens of columns, gradients, or mobile phase combinations each time, since the extra effort may not provide enough of a benefit to justify the cost and time in a fast-paced product development environment.
Analytical and Numerical Approaches to Mathematical Relativity
This book contains a representative collection of surveys by experts in mathematical relativity writing about the current status of, and problems in, their fields. There are four contributions for each of the following mathematical areas: differential geometry and differential topology, analytical methods and differential equations, and numerical methods. This book addresses graduate students and specialist researchers alike.
Analytic Number Theory : Lectures given at the C.I.M.E. Summer School held in Cetraro, Italy, July 11-18, 2002
The four contributions collected in this volume deal with several advanced results in analytic number theory. Friedlander’s paper contains some recent achievements of sieve theory leading to asymptotic formulae for the number of primes represented by suitable polynomials. Heath-Brown's lecture notes mainly deal with counting integer solutions to Diophantine equations, using among other tools several results from algebraic geometry and from the geometry of numbers. Iwaniec’s paper gives a broad picture of the theory of Siegel’s zeros and of exceptional characters of L-functions, and gives a new proof of Linnik’s theorem on the least prime in an arithmetic progression. Kaczorowski’s article presents an up-to-date survey of the axiomatic theory of L-functions introduced by Selberg, with a detailed exposition of several recent results.
Analysis, Synthesis, and Perception of Musical Sounds : The Sound of Music
Analysis, Synthesis, and Perception of Musical Sounds contains a detailed treatment of basic methods for analysis and synthesis of musical sounds, including the phase vocoder method, the McAulay-Quatieri frequency-tracking method, the constant-Q transform, and methods for pitch tracking with several examples shown. Various aspects of musical sound spectra such as spectral envelope, spectral centroid, spectral flux, and spectral irregularity are defined and discussed. One chapter is devoted to the control and synthesis of spectral envelopes. Two advanced methods of analysis/synthesis are given: "Sines Plus Transients Plus Noise" and "Spectrotemporal Reassignment" are covered. Methods for timbre morphing are given. The last two chapters discuss the perception of musical sounds based on discrimination and multidimensional scaling timbre models.
Analysis II : Differential and Integral Calculus, Fourier Series, Holomorphic Functions
Functions in R and C, including the theory of Fourier series, Fourier integrals and part of that of holomorphic functions.It is suitable for both teaching and self-study. In his familiar, personal style, the author emphasizes ideas over calculations and, avoiding the condensed style frequently found in textbooks, explains these ideas without parsimony of words.
Analysis II
As with the first, the second volume contains substantially more material than can be covered in a one-semester course. Such courses may omit many beautiful and well-grounded applications which connect broadly to many areas of mathematics. We of course hope that students will pursue this material independently; teachers may find it useful for undergraduate seminars. For an overview of the material presented, consult the table of contents and the chapter introductions. As before, we stress that doing the numerous exercises is indispensable for understanding the subject matter, and they also round out and amplify the main text. In writing this volume, we are indebted to the help of many.
Analysis and Design of Advanced Multiservice Networks Supporting Mobility, Multimedia, and Internetworking : COST Action 279 Final Report
This book reports on the state-of-the-art work developed during the four years of operation of COST Action 279, Analysis and Design of Advanced Multiservice Networks Supporting Mobility, Multimedia, and Internetworking, by its participating researchers, originating from over 40 research institutions from the academic, industrial, and telecom operator worlds. The work includes both fundamental, methodological, and applied aspects of network performance evaluation and design. The book contains a detailed account of the work developed, supported on an extensive bibliography of material published in the peer-reviewed literature.
Analysis and Algorithms for Service Parts Supply Chains
Services requiring parts has become a $1.5 trillion business annually worldwide, creating a tremendous incentive to manage the logistics of these parts efficiently by making planning and operational decisions in a rational and rigorous manner. This book provides a broad overview of modeling approaches and solution methodologies for addressing service parts inventory problems found in high-powered technology and aerospace applications. The focus in this work is on the management of high cost, low demand rate service parts found in multi-echelon settings. This unique book, with its breadth of topics and mathematical treatment, begins by first demonstrating the optimality of an order-up-to policy [or (s-1,s)] in certain environments. This policy is used in the real world and studied throughout the text. The fundamental mathematical building blocks for modeling and solving applications of stochastic process and optimization techniques to service parts management problems are summarized extensively. A wide range of exact and approximate mathematical models of multi-echelon systems is developed and used in practice to estimate future inventory investment and part repair requirements.
Analyse céphalométrique fonctionnelle et esthétique de profil = Functional and aesthetic cephalometric profile analysis
The complexity of the craniofacial architecture explains the multiplicity of cephalometric analyzes, too often based on points without phylogenetic, ontogenetic, anatomical or biomechanical justification. The value of a reliable and rapid analysis designed from indisputable fundamental foundations is essential. It enables the use of cephalometry in the daily practice of orthodontists, maxillofacial surgeons and facial plastic surgeons. This functional and aesthetic cephalometric analysis is carried out from fourteen anatomical points, ten bony points and four skin points, which all have in common that they are exo-basicranial. This analysis is easy to understand and use. It only takes five minutes to be learned and five minutes to be traced (fifteen seconds if it is computerized). The resulting results are reliable. The functional and aesthetic analysis is developed through four chapters. The first is devoted to the fundamental bases, the second to the analysis itself and to clinical cases, the third to the comparative study of different cephalometric analyzes, and finally the fourth chapter revisits the work of Arne Björk.
Analog Circuit Design : Sensors, Actuators and Power Drivers ; Integrated Power Amplifiers from Wireline to RF ; Very High Frequency Front Ends
This book is part of the Analog Circuit Design series and contains the revised contributions of all speakers of the 16th AACD Workshop, which was organized by Jan Sevenhans of AMI Semiconductor and held in Oostende, Belgium on March 27-29, 2007. The book comprises 17 tutorial papers, divided in three chapters, each discussing a very relevant topic in present days analog design.
Analog Circuit Design : RF Circuits : Wide band, Front-Ends, DAC's, Design Methodology and Verification for RF and Mixed-Signal Systems, Low Power and Low Voltage
Analog Circuit Design contains the contribution of 18 tutorials of the 14th workshop on Advances in Analog Circuit Design. Each part discusses a specific todate topic on new and valuable design ideas in the area of analog circuit design. Each part is presented by six experts in that field and state of the art information is shared and overviewed. This book is number 14 in this successful series of Analog Circuit Design, providing valuable information and excellent overviews of analog circuit design, CAD and RF systems.
