الصفحة 6
الصفحة 6
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
DNA nanotechnology for cell research : from bioanalysis to biomedicine
Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery.
DNA- and RNA-Based Computing Systems
DNA- and RNA-Based Computing Systems delivers an authoritative overview of DNA- and RNA-based biocomputing systems that touches on cutting-edge advancements in computer science, biotechnology, nanotechnology, and materials science.
Cosmeceuticals as Game Changers in the Cosmetic Industry
Objectives of this work is to compare conventional cosmetics to biotechnology derived cosmeceuticals in terms of skin anti-aging, skin color modulation and hair growth, and to find out which is of greater overall performance. Research revealed superiority of cosmeceuticals to classical cosmetics as it was found that many classical cosmetic agents used for aesthetical purposes posed a certain level of either ineffectiveness, for the reason that the effect did not treat the cause of the problem and was merely temporary and external, or harmfulness because of proposed potential health risks and adverse effects. Whereas cosmeceuticals presented promising novel mechanisms and compounds for a deeper, more thorough remedy.
Concepts in pharmaceutical biotechnology and drug development
Provides comprehensive coverage of the development of new pharmaceuticals and the enhancement of existing ones. It offers a comprehensive understanding of pharmaceutical biotechnology, including its underlying principles and practical applications from an industrial standpoint. While introducing the roles and applications of biotechnology in drug design and development, the book describes how developments in other fields, like genomics, proteomics, and high-throughput screening, have facilitated the discovery of novel therapeutic targets and drug development methods. It included concepts that are essential to biotechnology and apply to protein therapies. And provides a thorough overview of the ways in which biotechnology influences drug development, production, and regulation, and is a valuable resource for those seeking to enhance their understanding in this area.
Computer Aided Pharmaceutics and Drug Delivery : An Application Guide for Students and Researchers of Pharmaceutical Sciences
Examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics.
Colloids for Nano- and Biotechnology
This volume contains a selection of the papers presented at the 9th Conference on Colloid Chemistry. A colloid chemical approach to nano- and biotechnology was one of the main topics of the meeting held in Siófok, Hungary in October 2007. It was organized by the Hungarian Chemical Society in cooperation with leading Hungarian universities and the Hungarian Academy of Sciences. The contributions demonstrated the progress of the field and supported that "The world of neglected dimensions" should not be neglected at all in modern material sciences and technologies. This volume is intended for professionals dealing with fundamental research or development of industrial applications, who encounter colloids, nanostructures, and interfacial phenomena during their work.
CMOS Biotechnology
"CMOS Biotechnology reviews the recent research and developments joining CMOS technology with biology. Written by leading researchers these chapters delve into four areas including: Microfluidics for electrical engineers / CMOS Actuators CMOS Electrical Sensors CMOS Optical Sensors Bioanalytical instruments have been miniaturized on ICs to study various biophenomena or to actuate biosystems. These bio-lab-on-IC systems utilize the IC to facilitate faster, repeatable, and standardized biological experiments at low cost with a small volume of biological sample. CMOS Biotechnology will interest electrical engineers, bioengineers, biophysicists as well as researchers in MEMS, bioMEMS, microelectronics, microfluidics, and circuits and systems."
Marine Biotechnology II
This volume of Advances in Biochemical Engineering/Biotechnology illustrates several topics in line with the following broad objectives: thinking of marine biotechnology as the controlled production and use of marine organisms and molecules for useful purposes, firstly by exploring aspects of marine biodiversity and exploitation of biomass, then considering the identification, production and processing of marine products.
Marine Biotechnology I
Oceans, which occupy up to two thirds of the surface of our planet, were not really approached from scientific point of view until the second half of the 19th century and even the 20th with regard to microbial and unicellular life. Today, the importance of marine biodiversity has been fully recognized. It is, indeed, one of the aspects which, over the two past decades, have made a major contribution to our knowledge and vision of the living planetThis volume of Advances in Biochemical Engineering/Biotechnology illustrates several topics in line with the following broad objectives: thinking ofmarine biotechnology as the controlled production and use of marine organisms and molecules for useful purposes, firstly by exploring aspects of marine biodiversity and exploitation of biomass, then considering the identification, production and processing of marine products.
Manufacturing of Pharmaceutical Proteins: From Technology to Economy
Manufacturing of Pharmaceutical Proteins: From Technology to Economy, renowned chemical engineer Dr. Stefan Behme delivers a comprehensive text covering all aspects of biopharmaceutical manufacturing, including legal and regulatory considerations, production facility design, quality assurance, supply chain management, emerging market regulations, and cost control.
Managing Nano-Bio-Info-Cogno Innovations : Converging Technologies in Society
Tremendous human progress is becoming possible through the development of converging technologies stimulated by advances in four core fields: Nanotechnology, Biotechnology Information technology, and new technologies based in Cognitive science (NBIC). This book provides a unique review of technical developments related to the unification that is rapidly taking place today among these fields.
Magnetoreception and Magnetosomes in Bacteria
Recent developments in the research on magnetotactic bacteria are presented in this volume. Included are reviews on the formation and organization of magnetosomes, the genes controlling magnetosome biomineralization, and new cryogenic techniques to visualize novel cytoskeleton structures. Described here are potential nanobiotechnological applications of the magnetosome crystals, which have magnetic and crystalline characteristics unmatched by their inorganic counterparts.
Magnetic nanoparticles in human health and medicine : Current medical applications and alternative therapy of cancer
Progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery. Focusing on cancer diagnosis and therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine.
Machine learning for biomedical application
Biomedicine is a multidisciplinary branch of medical science that consists of many scientific disciplines, e.g., biology, biotechnology, bioinformatics, and genetics; moreover, it covers various medical specialties. In recent years, this field of science has developed rapidly. This means that a large amount of data has been generated, due to (among other reasons) the processing, analysis, and recognition of a wide range of biomedical signals and images obtained through increasingly advanced medical imaging devices. The analysis of these data requires the use of advanced IT methods, which include those related to the use of artificial intelligence, and in particular machine learning. It is a summary of the Special Issue “Machine Learning for Biomedical Application”, briefly outlining selected applications of machine learning in the processing, analysis, and recognition of biomedical data, mostly regarding biosignals and medical images.
Low-cost methods for molecular characterization of mutant plants : Tissue desiccation, DNA extraction and mutation discovery : Protocols
Offers low-cost and rapid molecular assays for the characterization of mutant plant germplasm. Detailed protocols are provided for the desiccation of plant tissues; the extraction of high-quality DNA for downstream applications; the extraction of single-strand-specific nucleases for single nucleotide polymorphism; and small insertion/deletion discovery using standard agarose gel electrophoresis. The methods described can be applied in any laboratory equipped for basic molecular biology and do away with the need for expensive freezers and toxic organic compounds.
Landscapes, Genomics and Transgenic Conifers
What is the future of genetically modified (or transgenic) conifer plantations? The content of this edited volume Landscapes, Genomics and Transgenic Conifers addresses this question directly - and indirectly - using language drawn from policy, forest history, genomics, metabolism, pollen dispersal and gene flow, landscape ecology, evolution, economics, technology transfer and regulatory oversight. Although the book takes its title from a Nicholas School Leadership forum held November 17-19, 2004 at Duke University, its de novo contents move past the forum’s deliberations. The result is a trans-disciplinary book composed of 14 chapters written by a total of 31 authors working in North America, South America, Europe and Africa.
Java for Bioinformatics and Biomedical Applications
Illustrates how individual bioinformatics applications (such as BLAST and Genscan) can be stitched together into a pipeline so that users can direct the output of one tool (for example, gene predictions using Genscan) to perform further analysis (say, homology searching using BLAST).
Computational biology in drug discovery and repurposing
Takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designin
Cleaning validation : Practical compliance approaches for pharmaceutical manufacturing
Timely coverage of cleaning validation for the pharmaceutical industry, a dynamic area in terms of health-based limits. Encourages pharmaceutical manufacturers, and particularly upper management, to meet the challenges of the science-based and riskbased approaches to cleaning validation. Draws on the author’s vast experience in the field of cleaning validation and hazardous materials. Discusses EMA vs. ISPE on Cleaning Limits and revised Risk-MaPP for highly hazardous products in shared facilities. A diverse list of topics from protocol limits for yeasts and molds to cleaning validation for homeopathic drug products.
