الصفحة 5
الصفحة 5
Dynamic Analysis of Structures
Reflects the latest application of structural dynamics theory to produce more optimal and economical structural designs. The author includes carefully worked-out examples which are solved utilizing more recent numerical methods. These examples pave the way to more accurately simulate the behavior of various types of structures. The essential topics covered include principles of structural dynamics applied to particles, rigid and deformable bodies, thus enabling the formulation of equations for the motion of any structure.
Drugs and a methodological compendium : From bench to bedside
Provides a meticulous view on methodological drug discovery and development insights from bench to bedside. Focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. Covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
Drug Selectivity : An Evolving Concept in Medicinal Chemistry
Provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Drug delivery via nasal route
Over the past 10 years, the interest in intranasal drug delivery has increased. The objective of this research is to summarize recent developments on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, nevertheless, there are still formulation limitations and side effects to be optimized. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This research describes the anatomical, histological and physiological basis and summarizes currently approved drugs for administration via intranasal delivery. Further, the research focuses on advantages and disadvantages of intranasal applied compounds and discusses formulation aspects that need to be considered for drug development.
Drug delivery systems using quantum computing
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells, and subcellular organs for drug release and absorption through a variety of drug carriers. By controlling the precise level and/or location of a given drug in the body, side effects are reduced, doses are lowered, and new therapies are possible. Nevertheless, there are still significant obstacles to delivering certain medications to particular cells. Drug delivery methods change pharmacokinetic, pharmacodynamic, and drug release patterns to enhance product efficacy and safety, as well as patient convenience and compliance.
Drug delivery aspects : Expectations and realities of multifunctional drug delivery systems ; Vol.4 : Expectations and realities of multifunctional drug delivery systems
Reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction.
Drug Delivery Approaches : Perspectives from Pharmacokinetics and Pharmacodynamics
Delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes.
Domain Decomposition Methods for the Numerical Solution of Partial Differential Equations
Domain decomposition methods are divide and conquer methods for the parallel and computational solution of partial differential equations of elliptic or parabolic type. They include iterative algorithms for solving the discretized equations, techniques for non-matching grid discretizations and techniques for heterogeneous approximations. This book serves as an introduction to this subject, with emphasis on matrix formulations. The topics studied include Schwarz, substructuring, Lagrange multiplier and least squares-control hybrid formulations, multilevel methods, non-self adjoint problems, parabolic equations, saddle point problems (Stokes, porous media and optimal control), non-matching grid discretizations, heterogeneous models, fictitious domain methods, variational inequalities, maximum norm theory, eigenvalue problems, optimization problems and the Helmholtz scattering problem. Selected convergence theory is included.
Discontinuous Finite Elements in Fluid Dynamics and Heat Transfer
Discontinuous Finite Elements in Fluid Dynamics and Heat Transfer offers its readers a systematic and practical introduction to the discontinuous finite element method. It moves from a brief review of the fundamental laws and equations governing thermal and fluid systems, through a discussion of different approaches to the formulation of discontinuous finite element solutions for boundary and initial value problems, to their applicaton in a variety of thermal-system and fluid-related problems, including: heat conduction problems / convection-dominant problems / computational compressible flows / external radiation problems / internal radiation and radiative transfer / free- and moving-boundary problems / micro- and nanoscale heat transfer and fluid flow / thermal fluid flow under the influence of applied magnetic fields.
Digital self-tuning controllers : Algorithms, implementation and applications
Digital Self-tuning Controllers presents you with a complete course in self-tuning control, beginning with a survey of adaptive control and the formulation of adaptive control problems. Modelling and identification are dealt with before passing on to algebraic design methods and particular PID and linear-quadratic forms of self-tuning control. Finally, laboratory verification and experimentation will show you how to ground your theoretical knowledge in real plant control.
Differential Evolution ; Vol.5 : In Search of Solutions
The human being aspires to the best possible performance. Both individuals and enterprises are looking for optimal—in other words, the best possible—solutions for situations or problems they face. Most of these problems can be expressed in mathematical terms, and so the methods of optimization undoubtedly render a significant aid. In cases where there are many local optima; intricate constraints; mixed-type variables; or noisy, time-dependent or otherwise ill-defined functions, the usual methods don’t give satisfactory results. Are you seeking fresh ideas or more efficient methods, or do you perhaps want to be well-informed about the latest achievements in optimization? If so, this book is for you. This book develops a unified insight on population-based optimization through Differential Evolution, one of the most recent and efficient optimization algorithms. You will find, in this book, everything concerning Differential Evolution and its application in its newest formulation.
Delivery of drugs ; Vol.2 : Expectations and realities of multifunctional drug delivery systems
Examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects.This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders.
Decoding the city urbanism in the Age of Big Data
Shows how Big Data change reality and, hence, the way we deal with the city. They demonstrate how the Lab interprets digital data as material that can be used for the formulation of a different urban future. The publication also looks at the negative aspects of the city-related data acquisition and control.
Data structure and algorithms using C++ : A practical implementation
Intended to flow from the basic concepts of C++ to technicalities of the programming language, its approach and debugging. The chapters of the book flow with the formulation of the problem, it's designing, finding the step-by-step solution procedure along with its compilation, debugging and execution with the output. Keeping in mind the learner’s sentiments and requirements, the exemplary programs are narrated with a simple approach so that it can lead to creation of good programs that not only executes properly to give the output, but also enables the learners to incorporate programming skills in them. The style of writing a program using a programming language is also emphasized by introducing the inclusion of comments wherever necessary to encourage writing more readable and well commented programs. As practice makes perfect, each chapter is also enriched with practice exercise questions so as to build the confidence of writing the programs for learners.
Data assimilation fundamentals : A unified formulation of the state and parameter estimation problem
This textbook's significant contribution is the unified derivation of data-assimilation techniques from a common fundamental and optimal starting point, namely Bayes' theorem. Unique for this book is the "top-down" derivation of the assimilation methods. It starts from Bayes theorem and gradually introduces the assumptions and approximations needed to arrive at today's popular data-assimilation methods. This strategy is the opposite of most textbooks and reviews on data assimilation that typically take a bottom-up approach to derive a particular assimilation method.
Data Assimilation : The Ensemble Kalman Filter
Data Assimilation comprehensively covers data assimilation and inverse methods, including both traditional state estimation and parameter estimation. This text and reference focuses on various popular data assimilation methods, such as weak and strong constraint variational methods and ensemble filters and smoothers. It is demonstrated how the different methods can be derived from a common theoretical basis, as well as how they differ and/or are related to each other, and which properties characterize them, using several examples.It presents the mathematical framework and derivations in a way which is common for any discipline where dynamics is merged with measurements. The mathematics level is modest, although it requires knowledge of basic spatial statistics, Bayesian statistics, and calculus of variations. Readers will also appreciate the introduction to the mathematical methods used and detailed derivations, which should be easy to follow, are given throughout the book. The codes used in several of the data assimilation experiments are available on a web page.The focus on ensemble methods, such as the ensemble Kalman filter and smoother, also makes it a solid reference to the derivation, implementation and application of such techniques. Much new material, in particular related to the formulation and solution of combined parameter and state estimation problems and the general properties of the ensemble algorithms, is available here for the first time.
Current Advances in Drug Delivery Through Fast Dissolving
Presents detailed information about FDDFs (Fast Dissolving/Disintegrating Dosage Forms) from their inception to recent developments. Readers will learn about the technical details of various FDDF manufacturing methods, formulation aspects, evaluation and methods to conduct clinical studies. The authors also give examples of marketed fast disintegrating/dissolving drug products in US, Europe, Japan, and India. This reference is ideal for pharmacology students at all levels seeking information about this specific form of drug delivery and formulation.
Crystallography and the World of Symmetry
Symmetry exists in realms from crystals to patterns, in external shapes of living or non-living objects, as well as in the fundamental particles and the physical laws that govern them. In fact, the search for this symmetry is the driving force for the discovery of many fundamental particles and the formulation of many physical laws. While one can not imagine a world which is absolutely symmetrical nor can one a world which is absolutely asymmetrical. These two aspects of nature are intermingled with each other inseparably. This is the basis of the existence of aperiodicity manifested in the liquid crystals and also quasi-crystals also discussed in Crystallography and the World of Symmetry.
Crisis and Reflection : An Essay on Husserl's Crisis of the European Sciences
In his last work, "Crisis of the European Sciences and Transcendental Phenomenology", Edmund Husserl formulated a radical new approach to phenomenological philosophy. Unlike his previous works, in the "Crisis" Husserl embedded this formulation in an ambitious reflection on the essence and value of the idea of rational thought and culture, a reflection that he considered to be an urgent necessity in light of the political, social, and intellectual crisis of the interwar period. In this book, James Dodd pursues an interpretation of Husserl's text that emphasizes the importance of the problem of the origin of philosophy, as well as advances the thesis that, for Husserl, the "crisis of reason" is not a contingent historical event, but a permanent feature of a life in reason generally.
Cosmetic creams development and formulation of effective skin care products
A guide to cosmetic creams that focuses on formulation, production, and safety concerns. It puts the focus on the structure and formulation of a cosmetic cream, the production process, the effect of each ingredient, as well as safety considerations. Comprehensive in scope, the book contains a basic definition of cosmetics and describes the types of skin creams currently on the market, the major ingredients used, and example compositions. The author, Wilfried Rähse?a noted expert on the topic?offers guidelines for estimating manufacturing costs and includes procedures for an effective safety assessment.
