الصفحة 5
الصفحة 5
Appropriate Dose Selection - How to Optimize Clinical Drug Development
Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers – based on the (known) pharmacology of the drug and/or biology of the underlying disease – along with exposure–response evaluation throughout all phases of drug development can quantitatively integrate clinical pharmacology knowledge, provide early proof of concept, and help in rational dose selection and rational drug product labeling for clinical use.
Applications and theory of Petri Nets 2005 ; 26th international conference, ICATPN 2005, Miami, FL, June 20-25, 2005, Proceedings
This volume contains the proceedings of the 26th International Conference on Application and Theory of Petri Nets and Other Models of Concurrency (ICATPN 2005). The Petri net conferences serve to discuss yearly progress in the ?eld of Petri nets and related models of concurrency, and to foster new - vancesintheapplicationandtheoryofPetrinets. Several tutorials and workshops were organized within the conf- ence, covering introductory and advanced aspects related to Petri nets.Detailed
Applications and Theory of Petri Nets ; 29th International Conference, PETRI NETS 2008, Xi’an, China, June 23-27, 2008. Proceedings
This book constitutes the refereed proceedings of the 29th International Conference on Applications and Theory of Petri Nets and Other Models of Concurrency, PETRI NETS 2008, held in Xi'an, China, in June 2008.
Application and Theory of Petri Nets 2002 ; 23rd International Conference, ICATPN 2002, Adelaide, Australia, June 24-30, 2002. Proceedings
This book constitutes the refereed proceedings of the 23rd International Conference on Application and Theory of Petri Nets, ICATPN 2002, held in Adelaide, Australia, in June 2002. The 18 regular papers and one tool presentation presented together with six invited paper were carefully reviewed and selected from 45 submissions. All current issues on research and development of Petri nets are addressed, in particular concurrent systems analysis, model validation, business process management, reactive systems, workflow processes, wireless transaction protocols.
Another side of drugs
Drug interactions remain an important consequence of pharmacologic intervention. It is clear that the pharmacologic response of a drug can be markedly influenced by concurrent administration of another therapeutic agent or food. These interactions may result in a decreased therapeutic effect or in an increase in the amount and extent of untoward reactions. Despite the well-described and real clinical consequences of certain drug interactions, this aspect of patient care often continues to be overlooked.
Airport Building Information Modelling
Details how Building Information Modelling is being successfully deployed in the planning, design, construction and future operation of the Istanbul New Airport, a mega-scale construction project incorporating a varying mix of infrastructures including terminals, runways, passenger gates, car parks, railways and roads. The book demonstrates how Airport Building Information Modelling (ABIM) is being used to: • facilitate collaboration, cooperation and integrated project delivery • manage subcontractors and eliminate cost over-runs • reduce waste on site and enhance overall quality • connect people in a virtual environment to encourage collaborative working • provide clients with an effective interface for lifecycle management including: design development, construction documentation, construction phases and BIM and Big Data Integration for future facilities management
Advances in cryptology - ASIACRYPT 2008 ; 14th International conference on the theory and application of cryptology and information security, Melbourne, Australia, December 7-11, 2008. Proceedings
Constitutes the refereed proceedings of the 14th International Conference on the Theory and Application of Cryptology and Information Security, ASIACRYPT 2008, held in Melbourne, Australia, in December 2008.
Advanced Topics in Exception Handling Techniques
Modern software systems are becoming more complex in many ways and are having to cope with a growing number of abnormal situations which, in turn, are increasingly complex to handle.This book is composed of five parts; the first four deal with topics related to exception handling in the context of programming languages, concurrency and operating systems, pervasive computing systems, and requirements and specifications. The last part focuses on case studies, experimentation and qualitative comparisons. The 16 coherently written chapters by leading researchers competently address a wide range of issues in exception handling.
A High-Performance Logical Framework -- All About Maude : How to Specify, Program, and Verify Systems in Rewriting Logic
This book gives a comprehensive account of Maude, a language and system based on rewriting logic. Many examples are used throughout the book to illustrate the main ideas and features of Maude, and its many possible uses. Maude modules are rewrite theories. Computation with such modules is - cient deduction by rewriting. Because of its logical basis and its initial model semantics,aMaude module defines a precise mathematical model.This means that Maude and its formal tool environment can be used in three, mutually reinforcing ways: • as a declarative programming language; • as an executable formal specification language; and • as a formal verification system. Maude’s rewriting logic is simple, yet very expressive. This gives Maude good representational capabilities as a semantic framework to formally represent a wide range of systems, including models of concurrency, distributed al- rithms, network protocols, semantics of programming languages, and models of cell biology. Rewriting logic is also an expressive universal logic,making Maude a fiexible logical framework in which many difierent logics and - ference systems can be represented and mechanized. This makes Maude a useful metatool to build many other tools, including those in its own formal tool environment. Thanks to the logic’s simplicity and the use of advanced semi-compilation techniques, Maude has a high-performance implementation, making it competitive with other declarative programming languages.
3D Manufacturing Innovation : Revolutionary Change in Japanese Manufacturing with Digital Data
3D Manufacturing Innovation introduces the best practices developed by Toyota, Sony, Nikon, Casio and other pioneers in the global engineering scene, providing the reader with invaluable tips for manufacturing innovation.
