الصفحة 44
الصفحة 44
Geology and Ecosystems
This book includes an analysis of the relationship between the different geological, hydrochemical, hydrogeological and engineering-geological processes and the processes within surface ecosystems. The analysis of specific interactions between the lithosphere and biosphere provides an integrated concept of the role of the geological environment in the evolution of the biosphere. The practical significance of the book is reflected by the analysis of modern engineering activity associated with the mining of minerals, excessive groundwater withdrawal, disposal of industrial and domestic wastes (including radioactive wastes) and their impacts on all components of the environment. Geology and Ecosystems includes a scientific approach to the complex monitoring of the environment under different natural and anthropogenic conditions, including the monitoring of permafrost regions. An important part of the book is the analysis of the "water factor" impact on ecosystems and sustainable development. Influences of intensive groundwater extraction on river flow, vegetation and land subsidence are also considered.
Geological Approaches to Coral Reef Ecology
By reconstructing the ecological history of coral reefs, the authors are able to evaluate whether or not recent, dramatic changes to reef ecosystems are novel events or part of a long-term trend or cycle. The contributions examine the interacting causes of change, which include hurricane damage, regional outbreaks of coral-consuming predators, disease epidemics, sea-level rise, nutrient loading, global warming and acidification of the oceans. Crucial predictions about the future of coral reefs lead to practical strategies for the successful restoration and management of reef ecosystems.
Genotype - Proteotype - Phenotype Relationships in Neurodegenerative Diseases
Improved understanding of role of protein dysmetabolism in neurodegeneration promises to improve diagnoses, facilitate the development of biological markers relevant to disease pathophysiology, and provide tractable therapeutic targets. This Fondation IPSEN conference summary provides an update on the latest advances of the role of protein misfolding in the pathophysiology of neurodegenerative diseases.
Genomics of Tropical Crop Plants
Genomics of Tropical Crop Plants summarizes recent progress on genomic research, including the development of molecular markers, genomic and cDNA libraries, expressed sequence tags (ESTs), genetic and physical maps, gene expression profiles, and whole genome sequences for 20 tropical crop plants. It offers background information about the evolutionary origin and environments of tropical crop species, international programs that are addressing the needs of tropical agriculture, and the potential for new technologies to increase the productivity and value of tropical crops. This book provides new dimensions to growing information concerning temperate crops and their morphology, physiology, and parallel evolution in diverse plant lineages.
Genome instability in cancer development
Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes.
Genome editing in drug discovery
In Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues.
Genetic testing in reproductive medicine
Illustrates the importance and significance of molecular genetic testing in reproductive disorders. The present book covers the genetic testing in various reproductive system anomalies, including disorders of sexual development, male infertility (Y deletions, autosomal mutations, sperm DNA fragmentation), female infertility (PCOS and POF), mitochondrial DNA testing for oocyte quality, recurrent pregnancy loss, pre-term birth, endometrial receptivity, prenatal genetic screening, reproductive carrier screening, preimplantation genetic screening, endometrial cancer, cervical cancer and other related reproductive health disorders. Microbiome testing and its contribution to genetic testing in reproductive medicine are also discussed. Covers ethical, moral and technical challenges in genetic testing in reproductive medicine. The book aims to set up a standard with regard to genetic testing in the reproductive medicine field, encourage further data generation, and provide food for thought in the areas of lacunae.
Genetic Democracy : Philosophical Perspectives
GENETIC DEMOCRACY involves an in-depth analysis of the ethical, social and philosophical issues related to modern genetic research and gene technology. The aim of the book is to introduce systematic research on the social and ethical impacts of the use and development of genetically modified organisms (GMOs) as well as the acquisition, use and storage of human genetic information (HGI). The book contributes into enhancing public discussion and reaching fair and democratic decision-making practices in GMO and HGI use and development both on local and global level.
Genetic control of neuronal migrations in human cortical development
Introduction Cortical development is a complex, tightly regulated process that eventually leads to the six-layered adult human neocortex, the substrate of the unique cognitive, emotional, and social abilities of our species. The basic mechanisms of early cortical development are believed to be very similar among mammals, which has led to a tendency of extrapolating experimental data from rodents on humans.
Genetic Basis for Respiratory Control Disorders
The objective of the book is to supply state-of-the-art contributions about all aspects of respiratory control genetics, from the molecular to the system level. The book aims to review the full spectrum of available knowledge, which starts with early physiological studies in health and disease in humans and studies in rodents that suggested a hereditary component to respiratory control. The spectrum extends to recent work elucidating crucial molecular aspects of respiratory control development, from early embryonic specifications in the neural tube to the function of respiratory rhythm generators.
Genes, development, and cancer : The life and work of Edward B. Lewis
Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one volume.
Generative programming and component engineering ; 4th International conference, GPCE 2005, Tallinn, Estonia, September 29 - October 1, 2005, Proceedings
Generative Programming and Component Engineering (GPCE) is a leading - searchconferenceonautomaticprogrammingandcomponentengineering.These approaches to software engineering have the potential to revolutionize software development as automation and components revolutionized manufacturing. The conference brings together researchers and practitioners interested in adva- ing automation for software development. It is also a premier forum for cro- fertilization between the programming language and software engineering - search communities. GPCEaroseasajointconference, mergingthepriorconferenceonGenerative and Component-Based Software Engineering (GCSE) and the Workshop on - mantics, Applications, andImplementationofProgramGeneration(SAIG). The proceedingsofthepreviousGPCEconferenceswerepublishedintheLNCSseries of Springer as volumes2487,2830, and 3286.In 2005 GPCE wasco-locatedwith the International Conference on Functional Programming (ICFP) and the s- posium on Trends in Functional Programming (TFP), re?ecting the vigorous interaction between the functional programming and generative programming research communities. GPCE and ICFP are both sponsored by the Association for Computing Machinery. The quality and breadth of the papers submitted to GPCE 2005 was impr- sive. All 86 papers, including 5 papers for tool demonstrations, were rigorously reviewed by 17 highly quali?ed Program Committee members. The members of the Program Committee ?rst provided in-depth individual reviews of the s- mitted papers, and then debated the merits of the papers through an extended electronicProgramCommitteemeeting.After much(friendly) argument,25r- ular papers and 2 tool demonstration papers were selected for publication. The ProgramCommittee provided extensive technical feedback to the authors of the submittedpapers.Theconferenceprogramwascomplementedwiththreeinvited talks, three extended tutorials, and three all-day workshops.
Generalized Convexity, Generalized Monotonicity and Applications ; Proceedings of the 7th International Symposium on Generalized Convexity and Generalized Monotonicity
This volume contains a collection of refereed articles on generalized convexity and generalized monotonicity. The first part of the book contains invited papers with applications of (generalized) convexity to such diverse fields as algebraic dynamics of the Gamma function values, discrete optimization, Lipschitzian stability of parametric constraint systems, and monotonicity of functions. The second part contains contributions presenting the latest developments in generalized convexity and generalized monotonicity: its connections with discrete and with continuous optimization, multiobjective optimization, fractional programming, nonsmooth Aanalysis, variational inequalities, and its applications to concrete problems such as finding equilibrium prices in mathematical economics, or hydrothermal scheduling.
General ultrasound in the critically ill
General ultrasound in the critically ill describes a bedside tool destined for use by the intensivist and any physician involved in emergencies. It specifically deals with findings of immediate clinical relevance throughout the body. New emergency applications of ultrasound in the abdomen, the vessels, the head and the heart are considered. The major topic, the lung, is extensively discussed. Interventional ultrasound forms part of nearly every chapter. Flow charts simplify daily concerns: acute dyspnea, shock, unexplained fever, etc. The strong points and pitfalls of ultrasound are reviewed. Technical notes are mingled with general considerations. Benefiting from the extensive experience of an intensivist intimately familiar with ultrasound, this book accurately answers most daily problems arising in the critically ill. it offers not only an exhaustive atlas but also a permanent aid to the therapeutic decision. All in all, General ultrasound in the critically ill provides a key for practicing a kind of visual medicine. Since 1990 Daniel Lichtenstein has been an intensivist in a medical ICU which already occupied a pioneering place in echocardiography. He has from the beginning devoted his efforts to the development of general ultrasound. He regularly publishes studies on lung ultrasound, his main topic, in the international literature.
General Relativity
this book is a short and concise exposition of the central ideas of general relativity. Although the original audience was made up of mathematics students, the focus is on the chain of reasoning that leads to the relativistic theory from the analysis of distance and time measurements in the presence of gravity, rather than on the underlying mathematical structure. The geometric ideas - which are central to the understanding of the nature of gravity - are introduced in parallel with the development of the theory, the emphasis being on laying bare how one is led to pseudo-Riemannian geometry through a natural process of reconciliation of special relativity with the equivalence principle.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gene delivery systems development and applications
Covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.
Gene delivery systems : nano delivery technologies
Gene therapy involves altering the genes in the body's cells in an effort to treat or stop disease, instead of using drugs or surgery. This book discusses the development of gene therapy today, from the technology involved to gene correction and the advances in genome editing.
Gender Equality Programmers in Higher Education : International Perspectives
For the last twenty years gender equality has been on the agenda of national higher education policies both within Europe and beyond it.the authors of this book analyse under which circumstances equality programmes are successful. In order to develop a deeper understanding of the mechanisms of and barriers to gender equality in higher education this book presents comparative studies and research focusing on the development of gender equality policies in different countries, as well as studies on the conditions for implementing policies, changes in strategies and the evaluation of gender equality programmes.
Gender and the judiciary in Africa: from obscurity to parity
Addresses the important issue of the increasing numbers and varied roles of women judges and justices, as judiciaries evolve across the continent.Scholars of law, gender politics and African politics provide overviews of recent developments in gender and the judiciary in nine African countries that represent north.
