الصفحة 42
الصفحة 42
Bioadhesives in Drug Delivery
The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; and bioadhesive hydrogels and applications ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems ; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.
Bioactive Molecules and Medicinal Plants
Use of medicinal plants is as old as human civilization and continuous efforts are being made to improve medicinal plants or produce their products in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identifed from higher plants and microorganisms. Some plant-based drugs have been used for centuries and there is no alternative medicine for many drugs, such as cardiac glycosides. However, natural products research was sidelined to pave the way for com- natorial chemistry, which was expected to produce large numbers of synthetic compounds for high-throughput screening (HTS). This line of work has failed to deliver desirable results. Moreover, it is not possible for all pharmaceutical companies and institutions to adopt costly HTS technology. Therefore, medi- nal plants and their bioactive molecules are always in demand and are a central point of research. While planning this book, we endeavored to incorporate - ticles that cover the entire gamut of current medicinal plants research.
Bioactive Marine Natural Products
Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R&D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.
Big Data in Energy Economics
Combines energy economics and big data modeling analysis in energy conversion and management and comprehensively introduces the relevant theories, key technologies, and application examples of the smart energy economy. With the help of time series big data modeling results, energy economy managers develop reasonable and feasible pricing mechanisms of electricity price and improve the absorption capacity of the power grid. In addition, they also carry out scientific power equipment scheduling and cost–benefit analysis according to the results of data mining, so as to avoid the loss caused by accidental damage of equipment. Energy users adjust their power consumption behavior through the modeling results provided and achieve the effect of energy saving and emission reduction while reasonably reducing the electricity expenditure.
Benign anorectal diseases : Diagnosis with endoanal and endorectal ultrasound and new treatment options
New three-dimensional endoanal and endorectal ultrasonographic and magnetic resonance imaging techniques have given better insight into the complex anatomy of the pelvic floor and its pathologic modification in benign anorectal diseases. Obstetrical events leading to fecal incontinence in females, the relationship between fistulous tracks and the sphincter complex, and mechanisms of obstructed defecation syndrome can now be accurately evaluated, which is of fundamental importance for decision making.
Behavioral pharmacology of the cholinergic system
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Basis and Treatment of Cardiac Arrhythmias
Incorporating the information related to mechanisms and treatment of cardiac arrhythmia, this book discusses genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These approaches and implementations of anti-arrhythmic therapy derive from many decades of research.
Basic & Clinical Pharmacology
Covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters
Barile's clinical toxicology : Principles and mechanisms ; 3rd ed.
Examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. Special emphasis is placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. Includes the source, pharmacological and toxicological mechanism of action, detection and identification in body fluids, and treatment of exposure. An overview of protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology, are discussed. In addition, effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered
Bacterial resistance to disinfectants
Bacterial resistance to disinfection is an escalating concern within healthcare facilities, as it poses a significant threat to patient safety and infection control. This research paper aims to explore the various mechanisms underlying bacterial resistance to disinfection, including intrinsic and acquired resistance, as well as the phenomenon of cross-resistance to antibiotic which poses a serious threat worldwide...
Bacterial Physiology : A Molecular Approach
The application of new molecular methodologies in the study of bacterial behaviour and cell architecture has enabled new revolutionary insights and discoveries in these areas. While this has also raised a number of scientific mysteries about bacteria, it certainly improved our understanding of these organisms as complex and adaptive entities rather than just simple tiny buckets of enzymes. The value of this recent knowledge in bacterial physiology is not only restricted to fundamental biology, but it also extends to biotechnology and drug-discovery disciplines where understanding cell behaviour and structure is essential for better exploitation of useful bacteria and effective eradication of harmful ones. This makes a new text accommodating recent developments in bacterial physiology highly relevant to a wide range of readership including those interested in basic and applied knowledge.
Bacterial Genomes and Infectious Diseases
This book imparts fundamental knowledge on the structure, organization, and evolution of bacterial genomes. The value and power of comparative genomics and proteomics, bioinformatics, microarrays, and knockout animal models in analyzing genomes, bacteria-host interactions and disease are demonstrated. Also discussed are the genomes of virulent and nonvirulent strains and species, origin and evolution of pathogens, different models of bacteria-host interactions, and diseases mechanisms.
Aulton's pharmaceutics : The design and manufacture of medicines
A comprehensive textbook covering the design of dosage forms and all aspects of drug delivery systems. Pharmaceutics in its broadest sense is the 'art of the apothecary' or, in simple terms, pharmaceutical preparations. It remains a diverse subject in the pharmacy curriculum, encompassing design of drugs, their manufacture and the elimination of micro-organisms from the products.
Augmented Humanity : Being and Remaining Agentic in a Digitalized World
This book will examine the implications of digitalization for the understanding of humanity, conceived as a community of intelligent agency. It addresses important topics across a range of social and behavioral theories and identifies a range of novel mechanisms and their social behavioral effects. Across the book, the author highlights the expansion of intelligent processing capability brought about by digitalization and the challenges this exposes for integrating artificial and human capabilities
Auditory Trauma, Protection, and Repair
Protection and Repair presents recent developments in auditory research and their potential translation to the clinical setting. In particular the authors address the major entities of peripheral auditory trauma, discuss the underlying mechanisms, the central nervous system consequences, protective interventions and finally explore the possibilities to restore cochlear morphology and function.Two themes run through the chapters in this book: cellular homeostasis and cell death. In the broadest sense, all auditory pathologies are disorders of cellular homeostasis.
Atomistic modeling of materials failure
Atomistic Modeling of Materials Failure is an introduction to molecular and atomistic modeling techniques applied to solid deformation and fracture. Focusing on a variety of brittle, ductile and geometrically confined materials, this detailed overview includes computational methods at the atomic scale, and describes how these techniques can be used to model the dynamics of cracks, dislocations and other deformation mechanisms.
Asymmetric hydrogenation and transfer hydrogenation
Details its complex subject matter clearly and plainly and covers everything from catalyst development and reactions to mechanisms and applications in academia and industry. The papers included within come from many of the leading voices in their respective fields and represent the newest and best research available today.
Asymmetric Cell Division
Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
Asset Sales : Their Role in Restructuring and Financing Firms
Examines the corporate asset market and the mechanisms of asset sale transactions. The book then focuses on the theory of finance in asset sales (the efficiency and financing theory) and the extensive empirical literature now available. In light of recent and rapid technological and digital advances, the last section presents new perspectives on analyzing asset sales transactions. Chiefly intended as a primer for PhD students and academics, the book offers a road map of the empirical research landscape and suggests future research directions.
Aspects of physical biology : Biological water, protein solutions, transport and replication
The present volume focuses on three main subtopics (biological water, protein solutions as well as transport and replication), presenting for each of the them the on-going debates on recent results. The role of water in biological processes, the mechanisms of protein folding, the phases and cooperative effects in biological solutions, the thermodynamic description of replication, transport and neural activity, all are subjects that are revised in this volume, based on new experiments and new theoretical interpretations.
