الصفحة 4
الصفحة 4
Misbehaving Proteins : Protein (Mis)Folding, Aggregation, and Stability
Misfoldedaggregatedproteinoncewasconsideredasinterestingasyesterday’strash—a bothersome by-product of important and productive activities, to be disposed of and forgotten as quickly as possible. Yesterday’s trash has become today’s focus of cons- erable scienti?c interest for at least two reasons: (1) protein aggregates are at the core of a number of chronic degenerative diseases such as Alzheimer’s disease, and (2) - gregation poses signi?cant obstacles to the manufacture of safe, ef?cacious, and stable protein products. As interest in protein misfolding, aggregation, and stability has soared beyond the core group of traditional protein-folding scientists, and as substantial scienti?c progress in understanding and controlling protein misfolding has been achieved, the need to summarize the state of the art became manifest. Although there are many excellent texts and edited collections on protein structure and folding, these volumes tend to relegate protein misfolding and aggregation to a minor role. Review articles and books focused on the biological role of protein aggregates in diseases have been published recently.
Microscale and Nanoscale Heat Transfer
Constitutes a particularly complete and original collection of ideas, models, numerical methods and experimental tools which will prove invaluable in the study of microscale and nanoscale heat transfer. It should be of interest to research scientists and thermal engineers who wish to carry out theoretical research or metrology in this field, but also to physicists concerned with the problems of heat transfer, or teachers requiring a solid foundation for an undergraduate university course in this area.
Microplastic in the Environment : Pattern and Process
This book examines global plastic pollution, an issue that has become a critical societal challenge with implications for environmental and public health. This volume provides a comprehensive, holistic analysis on the plastic cycle and its subsequent effects on biota, food security, and human exposure. Importantly, global environmental change and its associated, systems-level processes, including atmospheric deposition, ecosystem complexity, UV exposure, wind patterns, water stratification, ocean circulation, etc., are all important direct and indirect factors governing the fate, transport and biotic and abiotic processing of plastic particles across ecosystem types.
Microgravity Two-phase Flow and Heat Transfer
Multiphase thermal systems (involving more than one phase or one component) have numerous applications in aerospace, heat-exchanger, transport of contaminants in environmental systems, and energy transport and energy conversion systems. Advances in understanding the behaviour of multiphase thermal systems could lead to higher efficiency energy production systems, improved heat-exchanger design, and safer and enhanced treatment of hazardous waste. But such advances have been greatly hindered by the strong effect of gravitational acceleration on the flow. Depending on the flow orientation and the phase velocities, gravitational forces could significantly alter the flow regime, and hence the pressure-drop and heat-transfer coefficients associated with the flow. A reduced gravity environment (or "microgravity"), provides an excellent tool to study the flow without the masking effects of gravity. This book presents for the first time a comprehensive coverage of all aspects of two-phase flow behaviour in the virtual absence of gravity.
Metric Handbook : Planning and Design Data
A major handbook of planning and design data for architects and architecture students. Covering basic design data for all the major building types, it is the ideal starting point for any project. For each building type, the book gives the basic design requirements and all the principal dimensional data, and succinct guidance on how to use the information and what regulations the designer needs to be aware of.
Methods of Measuring Moisture in Building Materials and Structures : State-of-the-Art Report of the RILEM Technical Committee 248-MMB
Provides the most recent overview of methods for measuring moisture Covers major applications in civil engineering Gives both the scientific background of methods and examples of their application
Methods and Models in Transport and Telecommunications : Cross Atlantic Perspectives
One aspect of the new economy is a transition to a networked society, and the emergence of a highly interconnected, interdependent and complex system of networks to move people, goods and information. An example of this is the in creasing reliance of networked systems (e. g. , air transportation networks, electric power grid, maritime transport, etc. ) on telecommunications and information in frastructure. Many of the networks that evolved today have an added complexity in that they have both a spatial structure , they are located in physical space but also an a spatial dimension brought on largely by their dependence on infor mation technology. They are also often just one component of a larger system of geographically integrated and overlapping networks operating at different spatial levels. An understanding of these complexities is imperative for the design of plans and policies that can be used to optimize the efficiency, performance and safety of transportation, telecommunications and other networked systems. In one sense, technological advances along with economic forces that encourage the clustering of activities in space to reduce transaction costs have led to more efficient network structures.
Mesoscale Analysis of Hydraulics
Presents a series of complicated hydraulic phenomena and related mechanism of high-speed flows in head-head dam. According to the basic hydraulic theory, detailed experiments and numerical simulations, microscopic scale analysis on cavitation bubbles, air bubbles, turbulent eddy vortices and sand grains are examined systemically. These investigations on microscopic fluid mechanics, including cavitation erosion, aeration protection, air–water flow, energy dissipation and river-bed scouring, allow a deep understanding of hydraulics in high-head dams. This book provides reference for designers and researchers in hydraulic engineering, environment engineering and fluid mechanics.
Membrane Trafficking in Viral Replication
The ability of viruses to exploit cellular functions for their own ends makes them highly effective pathogens and exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. Each of the eight chapters in this volume deals with a specific aspect of viral interactions with cellular membranes. These include chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. These chapters should provide both an overview of cellular membrane trafficking mechanisms and viral interactions with these systems, as well as reviews of the current state of each of the fields.
Medicina fisica e riabilitativa nei disturbi di equilibrio = Physical and rehabilitative medicine in balance disorders
Balance disorders are very common in the population: particularly frequent over the age of 40, are the first motivation for a medical examination after the age of 65 and frequently tend to become chronic. Balance disorders are symptoms of system dysfunction vestibular, complex sensory-psycho-motor system, whose task is that to control the activity of the antigravity muscles to maintain the erect station, of the oculomotor ones to allow the stabilization of the visual field during movement, and the neurovegetative functions they have relationship with standing and movement. Whether the vestibular system provides the information necessary for the check-up of the erect position, the rachis realizes it through a "stability dynamic ", allowed by its structural characteristics proprioception the spine is also a fundamental sensor for controlling balance ; therefore the techniques of physical and rehabilitative medicine and of manual medicine represent a powerful tool for curing ailments equilibrium. This volume comes from the comparison between a physiatrist and an audiologist, who for 15 years have integrated their clinical experience and therefore proposes a new one inter-specialist approach to the diagnostic and therapeutic problems of patients with balance disorders.
Medical Applications of Colloids
This volume collects chapters dealing with significant topics in colloids and surfaces relevant to medical applications. The book will be of interest to scientists and practitioners in areas as diverse as medical diagnostics, drug formulations, X-ray photoelectron spectroscopy of biomaterials, and particle transport in human airways.
Mathematics Is Not a Spectator Sport
Mathematics Is Not a Spectator Sport challenges the reader to become an active mathematician. Beginning at a gentle pace, the author encourages the reader to get involved, with discussions of an exciting variety of topics, each placed in its historical context, The chapters are largely self-contained and each topic can be understood independently. However, the author draws many connections between the various topics to demonstrate their interplay and role within the context of mathematics as a whole. Lots of carefully chosen problems are included at the end of each section to stimulate the reader's development as a mathematician.
Iron Nutrition in Plants and Rhizospheric Microorganisms
This book uses an interdisciplinary approach to provide a comprehensive review on the status of iron nutrition in plants. International scientists discuss research on acquisition of iron by strategy I and strategy II plants. These reviews summarize a variety of plant species and include both laboratory and field observations. Topics covered in this book include: plants as a source of iron for animals and humans, iron translocation in the plants, iron-stimulated activities that influence crop yield and fruit tree productivity, iron uptake by plants as influenced by microorganisms (i.e. free living soil microorganisms, symbiotic nitrogen-fixing and pathogenic bacteria), the role of plant hormones in iron transport, iron-metal competition in phytoremediation, root zone activities involving interactions between minerals and organic matter, the role of microbial siderophores in rhizospheric iron cycling, iron storage as phytoferritin, proteomic and metabolic studies associated with iron stress response, methods for studying iron metabolism including stable isotopes, and the correction of iron deficiency through the use of synthetic or natural chelates.
Ionic Soft Matter : Modern Trends in Theory and Applications; Proceedings of the NATO Advanced Research Workshop on Ionic Soft Matter: Modern Trends in Theory and Application Lviv, Ukraine, 14-17 April, 2004
Consists of reviews of the experimental, theoretical and simulation studies on ionic criticality, polyelectrolytes, proton transport in fuel cell membranes, and the design of DNA arrays. This book deals with discussions of the fundamental and applied problems of important phenomena such as ion association, ion adsorption, ion solvation.
Introduzione al Calcolo Scientifico : Esercizi e problemi risolti con MATLAB = Introduction to scientific computing : Exercises and problem solved with MATLAB
Introduces the fundamental concepts for the numerical modeling of partial differential problems. We consider the classic linear elliptic, parabolic and hyperbolic equations, but also other equations, such as those of diffusion and transport, of Navier-Stokes, and the conservation laws. Numerous physical examples underlying these equations are provided, their main mathematical properties are studied, then numerical resolution methods based on finite elements, finite differences, finite volumes and spectral methods are proposed and analyzed. In particular, the algorithmic and computer implementation aspects are discussed and some easy-to-use programs in C ++ language are provided. The text does not presuppose an advanced mathematical knowledge of partial differential equations: the strictly indispensable concepts in this regard are reported in the Appendix. THE VOLUME is therefore suitable for students of scientific degree courses (Engineering, Mathematics, Physics, Chemistry, Information Sciences) and recommended for researchers from the academic and extra-academic world who want to approach this interesting branch of applied mathematics.
Introduction to Intelligent Construction Technology of Transportation Infrastructure
Expounds on the related technologies of intelligent transportation infrastructure construction. Based on the essential characteristics of intelligent construction, "perception, analysis, decision-making, and execution," the basic structure of intelligent construction technology (ICT) is established. With the integration of engineering construction technologies, the analyses of the essence of intelligent algorithms and the feasibility of Artificial Intelligence (AI) are provided. The book introduces the essential characteristics of Big Data and the Internet of Things and their relationship with engineering construction. On this basis, the feasibility and implementation plan of intelligent technology applications in design, construction, and maintenance are analyzed and demonstrated with engineering examples.
Introduction to basics of pharmacology and toxicology ; Vol.1 : General and molecular pharmacology : Principles of drug action
Illustrates the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases.
Introducing Molecular Electronics
This volume presents a summary of our current understanding of molecular electronics combined with selected state-of-the-art results at a level accessible to the advanced undergraduate or novice postgraduate. This single book comprises the basic knowledge of both theory and experiment underpinning this rapidly growing field. Concepts and techniques such as density functional theory and charge transport, break junctions and scanning probe microscopy are introduced step-by-step and are subsequently used in specific examples. The text addresses a wide range of systems including molecular junctions made of single-molecules, self-assembled monolayers, carbon nanotubes and DNA.
International steam tables : Properties of water and steam based on the industrial formulation IAPWS-IF97 : Tables, algorithms, diagrams, and CD-ROM Electronic steam tables - All of the equations of IAPWS-IF97 including a complete set of supplementary backward equations for fast calculations of heat cycles, boilers, and steam turbines
This book contains steam tables for industrial use that have been calculated using the international standard for the thermodynamic properties of water and steam, the IAPWS-IF97 formulation, and the international standards for transport and other properties. In addition, the complete set of equations of IAPWS-IF97 is presented including all supplementary backward equations adopted by IAPWS between 2001 and 2005 for fast calculations of heat cycles, boilers, and steam turbines.
Interfacial Transport Phenomena
This is an extensively revised second edition of Interfacial Transport Phenomena, a unique presentation of transport phenomena or continuum mechanics focused on momentum, energy, and mass transfer at interfaces. In addition to tightening the focus of the book there are two important additions: an extended discussion of transport phenomena at common lines or three-phase lines of contact, as well as a new theory for the extension of continuum mechanics to the nanoscale region immediately adjacent to the interface. Applications and supporting experimental data are provided and discussed in detail. This book is written for the advanced student of transport phenomena. The emphasis is upon achieving an in-depth understanding based upon first principles. It is designed to prepare the reader for active research. It includes exercises and answers, and can serve as a graduate level textbook.
