الصفحة 4
الصفحة 4
Therapeutic Lipidology ; 2nd ed.
The chapters focus on recent advances in the field including novel biomarkers and the microbiome, genomics of cardiovascular risks, PCSK9 inhibitors, imaging technologies, and epidemiology of atherosclerotic cardiovascular disease. The book describes new guidelines, novel therapeutic agents, and changes in the understanding of specific lipoproteins and subclasses with regard to their relationships to cardiovascular disease risk. The second edition contains more than thirty chapters covering such topics as the history of lipidology, lipoprotein metabolism and vascular biology, disorders of lipid metabolism, lifestyle/dietary and pharmacologic management for dyslipidemia, the management of dyslipidemia in certain subgroups (e.g., women, children, older patients) and lipid testing, as well as an examination of other biomarkers and testing procedures related to atherosclerosis and cardiovascular disease.
Therapeutic Hypothermia
This volume will be of interest to both the researcher interested in therapeutic hypothermia as well as the clinician interested in the potential use of therapeutic hypothermia in their patient population.
Therapeutic drug targets and phytomedicine For triple negative breast cancer
Provides an overview of TNBC etiology, its treatment strategies and prognostic markers to identify the outcome of standard therapies. Signalling pathways namely cell proliferation, angiogenesis, invasion and metastasis, apoptosis, autophagy and others involved in complicating the disease have been described in the chapters to convey an understanding about the disease mechanisms. All the possible drugs either in pre-clinical or clinical stages have also been mentioned with data that depicts their efficiency in targeting altered genes. Introduces the reader to herbal medicine exhibiting high potency to target TNBC, their synthetic analogs used during chemotherapy and their ability to fight against chemoresistance. The concept of phytonanotechnology has also been discussed. Helps create awareness among a broad range of readers about TNBC. It points to prioritizing the upgradation of health care facilities and re-designing future treatment strategies to provide maximum benefit to breast cancer patients.
Therapeutic Dressings and Wound Healing Applications
Takes a clinical and scientific approach to wound healing, and includes recent case studies to highlight key points and areas of improvement. It is divided into two key sections that include insight into the biochemical basis of wounds, as well as techniques and recent advancements. Chapters include information on: Debridement and disinfection properties of wound dressing / Biofilms, silver nanoparticles, and honey dressings / Clinical perspectives for treating diabetic wounds / Treating mixed infections / Wound healing and tissue regeneration treatments / Gene based therapy, 3D bioprinting and freeze-dried wafers
Therapeutic approaches in cancer treatment
A unique blend of structured information covering a broad area relevant to cancer therapeutics.This book comprises fourteen chapters covering cancer genomic approaches for cancer treatment, traditional modalities, chemotherapy, radiotherapy, hormonal therapy, immunotherapy, oncolytic virotherapy, which is another emerging field. Furthermore, it also covers targeted therapies in personalized medicine, which is again an emerging yet promising field for cancer treatment. Use of nanocarriers in the cancer treatment is another important aspect which is a developing thrive. This book is also unique about in covering psychological elements in cancer treatments and providing knowledge for nutritional assessments in cancer treatment. The book has very good text highlighting the important features with a blend of traditional and emerging treatment modalities. Furthermore, chemoresistance development and challenges it poses in cancer treatment along with the pharmacogenetics of anticancer drug, which is way important for the clinicians to understand for their individual patients, associated toxicities, and clinical responses to a particular drug.
Therapeutic Applications of Honey and its Phytochemicals ; Vol.2
Provides evidence-based information on the pharmaceutical potential of honey along with its therapeutic applications and precise mechanisms of action. It discusses in detail the phytochemistry and pharmacological properties of honey, highlighting the economic and culturally significant medicinal uses of honey and comprehensively reviewing the scientific research on the traditional uses, chemical composition, scientific validation, and general pharmacognostical characteristics. Given its scope, it is a valuable tool for researchers and scientists interested in drug discovery and the chemistry and pharmacology of honey.
Therapeutic Applications of Honey and its Phytochemicals ; Vol.1
Provides evidence-based information on the pharmaceutical potential of honey along with its therapeutic applications and precise mechanisms of action. It discusses in detail the phytochemistry and pharmacological properties of honey, highlighting the economic and culturally significant medicinal uses of honey and comprehensively reviewing the scientific research on the traditional uses, chemical composition, scientific validation, and general pharmacognostical characteristics. Given its scope, it is a valuable tool for researchers and scientists interested in drug discovery and the chemistry and pharmacology of honey.
Therapeutic antibodies : Methods and protocols
Covers methods for studying, producing, and analyzing therapeutic antibodies, measuring their concentration, developing neutralizing antibodies for them, and for predicting and monitoring their therapeutic efficacy and clinical effects. These biologics are the fastest growing pharmaceutical drug group and have had tremendous clinical and scientific impact in cancer, autoimmune diseases, infectious diseases, and other immune-related diseases, making the content of this volume essential. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible methods, and tips on troubleshooting and avoiding known pitfalls.
Therapeutic Antibodies
Antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions and are becoming the molecules of choice for further combination therapies and cell engineering. Current developments and clinical successes are summarised by experts in the drug development field. A must read for immunologists, clinical scientists and novel drug developers.
Therapeutic Angiogenesis – Quo vadis
This collection of current and future concepts of neovascularization offers fascinating insights into refining a powerful therapeutic tool which has not yet had the chance to live up to the expectations and needs of the medical community.
The Universe in X-Rays
In the last 45 years, X-ray astronomy has become an integral part of modern astrophysics and cosmology. There is a wide range of astrophysical objects and phenomena, where X-rays provide crucial diagnostics. In particular they are well suited to study hot plasmas and matter under extreme physical conditions in compact objects. This book summarizes the present status of X-ray astronomy in terms of observational results and their astrophysical interpretation. It is written for students, astrophysicists as well a growing community of physicists interested in the field. An introduction including historical material is followed by chapters on X-ray astronomical instrumentation. The next two parts summarize in 17 chapters the present knowledge on various classes of X-ray sources in the galactic and extragalactic realm. While the X-ray astronomical highlights discussed in this book are mainly based on results from ROSAT, ASCA, RXTE, BeppoSAX, Chandra and XMM-Newton, a final chapter provides an outlook on observational capabilities and projects discussed for the future.
The structural transformation of European private law a critique of juridical hermeneutic
Proposes a new analysis of the transformation of Europe through integration, exactly 30 years after the beginning of transformation scholarship. It consists of a reconstruction of the development and present condition of European integration in relation to private ordering.
The Standard Model and Beyond ; Proceedings of the 2nd International Summer School in High Energy Physics, Muğla, 25–30 September 2006
This volume collects the edited tutorial lectures given at The Second International Summer School in High Energy Physics in Mgla, Turkey, in September 2006 - an annual event with international participation and a special focus on work done in the regions of central Asia. With emphasis on the standard model and beyond, lectures were devoted to presenting an introduction and update to many of the relevant topics, such as chiral perturbation theory, the Higgs mechanism, heavy flavour and b physics, CP violation, the AdS/CFT correspondence, ideas on grand unification and neutrino physics and astrophysics
The silent epidemic
Biofilm is a complex structure of microbiome having bacterial colonies adhere to the surface. These cells are embedded in extracellular polymeric substances, a matrix generally composed of eDNA, proteins and polysaccharides, showing high resistance to antibiotics. Quorum sensing plays an important role in regulating the biofilm formation. Biofilm is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. There are many approaches being used to control biofilm. Indeed, the adhesive characteristics of natural human flora are now considered as a tool for preventing the adhesion of pathogenic bacteria to avert infection. These antibiofilm approaches represent a promising therapeutic target in the treatment of biofilm infections and development of a strong capability to interfere with different phases of the biofilm development.
The Serotonin Receptors : From Molecular Pharmacology to Human Therapeutics
The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice.
The School of God : Pedagogy and Rhetoric in Calvin's Interpretation of Deuteronomy
Examines Calvin’s exegesis and rhetoric in his commentary on the latter Pentateuch, as well as the sermons that Calvin preached on Deuteronomy—material that has received little scholarly attention. Calvin’s interpretations are compared with the preceding exegetical tradition and with his contemporaries, and always considered in the contexts of the early modern interest in classical rhetoric and that of the reform of church, theology, and society in Switzerland and beyond. Commonly held assumptions about Calvin’s methodology, such as his alleged aversion to rhetoric and the scholarly fixation on his laconic style, are challenged, nuanced, and corrected.
The Sarcomere and Skeletal Muscle Disease
Although best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options.
The Salton Sea Centennial Symposium ; Proceedings of a Symposium Celebrating a Century of Symbiosis Among Agriculture, Wildlife and People, 1905–2005, held in San Diego, California, USA, March 2005
This volume deals with many aspects of the physical and chemical limnology of the Salton Sea, California’s largest lake and a lake that may soon to be the object of a multi-billion dollar restoration project. Formed in 1905 by an accidental breaching of outtake structures on the Colorado River, and maintained since then by large and steady inflows of agricultural wastewaters, it has long served as an important habitat for fish and waterbirds and as a major recreational area for people. Highlly eutrophic and with a salinity that is steadily rising and now nearly 50 g/L, it is a lake in great trouble. Most fish species have disappeared, and large fish and bird dieoffs have been common in recent decades. Many of the papers in this volume represent studies undertaken with the aim of informing the re-engineering of this ecosystem so that its value to wildlife and man can be restored or enhanced.
The roles of variants in human multidrug resistance (MDR1) gene on drug response
MDR-1 belongs to a large family of ATP-binding cassette transporter proteins. These pumps bind their substrate and export it through the membrane using energy derived from ATP hydrolysis. In vivo and in vitro studies have demonstrated that MDR-1 plays a very significant role in the ADME processes (absorption, distribution, metabolism, excretion) and drug-drug interaction (DDI) of drugs in humans. Moreover, this efflux transporter is not only expressed in tumor cells, but also in normal tissues (Brain, intestine, liver and kidney) with excretory function that limits oral absorption and central nervous system entry of many drugs.
The role of vitamins in combating infectious viral diseases
Highlights the role of vitamins in preventing or reducing the pathogenesis or treatment of infectious viral diseases based on current ongoing research and past work. Using clinical evidence and trials that suggest the potential benefits of vitamin supplementation as prophylactic and therapeutic in infectious viral diseases, each individual vitamin is described in this context in separate chapters. It will be a valuable reference aid to researchers, clinicians, and medical bodies to develop improved therapeutic regimens.
