الصفحة 3
الصفحة 3
Magnesium
Until recently the physiological role of magnesium was essentially ignored. However, with the development of new technologies to measure the intracellular free concentration of magnesium ([Mg2+]i), the biologically important fraction, there has been an explosion of interest in the molecular, biochemical, physiological and pharmacological functions of magnesium. In addition improved methods for assessing magnesium status in the clinic have contributed to the further understanding of magnesium regulation in health and disease...
Liver and Pancreatic Diseases Management
New therapeutical approaches, advances in oncology and in diagnostic imaging, which reduce the need for invasive techniques and reach an improvement in survival and quality of life in cancer, are considered in this book. Modern literature has been reviewed with special reference to articles of general interest. In the clinical management of patients with liver, bile duct and pancreas diseases, it is important to assess the degree of disturbance and to diagnose the causative insult, and therefore clinical and laboratory methods of assessing each of these pathologies are of high interest. This version is an up-to-date account of diseases of the liver, biliary tract and pancreas, including transplantation, which we trust will be of value for surgeons, physicians and pathologists and also a reference book for medical students.
Learners in a Changing Learning Landscape: Reflections from a Dialogue on New Roles and Expectations
Today's learners face constant change. Adaptive learner expertise is key to their survival on a learning journey that lasts a lifetime. This requires new thinking of all actors in the learning environment. The fundamental process through which this book was created is an extended in-depth dialogue among researchers, lifelong learners, educators, and thinkers.
Cell Adhesion and Cytoskeletal Molecules in Metastasis
In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.
CD4+CD25+ Regulatory T Cells : Origin, Function and Therapeutic Potential
CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues.
Carbon monoxide in drug discovery, basics, pharmacology, and therapeutic potential
Carbon monoxide, one of the smallest organic natural molecules, is widely known for its toxicity. Formation of CO via incomplete combustion is a major contributing factor to accidental or intentional CO poisoning, leading to severe health consequences or death. In addition, CO is a by-product of tobacco smoking, and has been associated with some of the harmful effects of smoking. However, less known and probably far more important is the recognition of the essential physiological roles of CO as a signaling molecule in mammals. Against over more than a century of negative connotation, the last few decades have proven that CO possesses a multitude of physiological roles and therapeutic functions including regulation of the immune response, cellular proliferation, and control of cell survival. This concept is supported by the discovery that CO is produced by all cells and more so under conditions of stress. This book comprehensively summarizes key aspects of CO's endogenous roles, therapeutic functions, and challenges that we face in its development as a therapeutic agent. We hope this preface will provide a thread for reading this book and a birds-eye view of the landscape for understanding this field, and more importantly lay out the challenges ahead in understanding the detailed mechanisms of action of CO and in its development as a therapeutic agent.
Cancer immunotherapy
Defining Cancer as a disease in which some of the body's cells grow uncontrollably and spread to other parts of the body, making it an enormous medical and economic burden accounting for 9.6 million deaths in 2018. Cancer treatments were being introduced for a long time. The development of specific therapies to treat cancer really depends on the continued discovery of the molecular changes that lead to the malignant progression of human cancers. More and more drugs are being developed to block cancer pathways that lead to impaired growth and survival of cancer cells. In this dissertation, the concept of cellular and immunotherapy of cancer will be discussed briefly, taking into considerations the mechanisms of action, the advantages, challenges and drawbacks of the different types of monoclonal antibodies and CAR T-Cell therapy.
Cancer et traitement: Domicile ou hôpital : Le choix du patient = Cancer and treatment : Home or hospital : The patient's choice
This book takes stock of the needs, expectations and challenges of caring for a cancer patient at home or in hospital. Indeed, if the number of cancer cases is increasing in Western countries, their management is evolving. The emphasis today is on a more humane announcement of the disease, less aggressive treatments and a better quality of life. Better informed patients often wish to be treated at home. As the survival time lengthens, hospital stays are reduced and chosen. Home care teams will soon be relying on the hospital more easily, thanks to specific communication methods and care networks. Here, all the stakeholders involved in the psycho-oncological approach to the patient discuss the choice of place and means of treatment for patients: from the general practitioner to the psychologist, from the oncologist to the mobile palliative care unit.
Cancer
The last decade has seen a dramatic shift in anticancer drug research towards agents that aim to target selectively key regulatory and signaling processes known to drive tumorigenesis. A number of these newer agents have now been introduced into clinical practice. This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-nvasives. Each chapter aims to cover the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Business Ethics of Innovation
Firms that operate in a market economy often depend upon innovations in order to achieve competitive advantages that sustainably secure their survival. Business ethics is thus largely concerned with questions about the decisional freedoms involved in innovation processes. Innovations oftentimes raise novel questions about the role of the state or the structure of society. Business ethics needs to provide a framework for balancing the different perspectives, values, and interests at stake. This balance must be achieved at the level of the firm in order to facilitate adequate long term decisions, but it should also be sought at higher, including regulatory, levels. Achieving this balance will require an ethical framework for entrepreneurial action.
Business agility and information technology diffusion ; IFIP TC8 WG 8.6 International working Conference, May 8-11, 2005, Atlanta, Georgia, USA
Addresses issues related to business agility and the diffusion of Information Technology (IT). Success, even survival, in today's business environment has been made complex and difficult by technologically-based competitive pressure. One promising strategy is to be agile and ready to adapt quickly to changes in the environment or market. Such strategy takes shape as an agile software development, agile manufacturing, agile modeling and agile iterations. In contrast, successful IT diffusion is known to be a process that takes time and careful effort. Many IT projects that succeeded in developing a product have subsequently failed in changing the behavior of the target group when diffusion just didn't happen. Therefore this volume responds to the question: What is the relationship between agility and IT diffusion? The book's scope will cover information systems and technology issues, as well as organizational and managerial issues, related to agility and IT diffusion. The planned perspectives include topics such as diffusion of agile methods, enabling business agility with IT, creating agile environments that facilitate diffusion of IT, theories and frameworks for understanding diffusion and agility issues, best practices relating to business agility and IT diffusion, software process improvement and agility, diffusion studies of specific agile technologies, and impacts of diffusion of IT agile methods.
Bulk Fill Resin Composites in Dentistry : A Clinical Guide
Dedicated to all relevant aspects of bulk fill materials and their uses in clinical practice. Today, we count over 30 different bulk fill materials, which can be used in the dental clinic. The composition of bulk fill materials and their different modes of application for moderate to large direct resin restorations placement are explained in this book. It is written by a group of international specialists and allows the reader to evaluate available materials, learn predictable techniques and evaluate long term survival as well as future developments. The book covers all fields related to the history of bulk fill composites, their composition and physical properties, and a step by step guide to their successful clinical applications.
Breast Cancer Management and Molecular Medicine : Towards Tailored Approaches
This book provides an overview of the most recent techniques, agents and approaches for breast cancer that contribute to the individualization of treatment. Current biomedical research focuses on facilitating the transfer of molecular biology knowledge into the clinical management of patients, leading to increased survival as well as improved quality of life. Particular attention is given in this book to organ-specific tailored approaches, specific populations, patients’ preferences and rehabilitation.
Biostatistics and microbiology : A survival manual
This book presents a step-by-step manner that eliminates the greatest obstacle to the learner, which is applying the many processes that comprise a statistical method. The author counters the fear of statistical methods by describing early in the book a step-by-step procedure to perform a statistical method - a process that we will term "the six-step procedure." All of the testing will be performed adhering to six well-defined steps, which will greatly simplify the statistical process. Each step in the sequence must be completed before moving on to the next step.
Best diagnostic tools and supportive medication for cancer patients
Cancer is still a lethal disease despite the development of new effective therapies; therefore the purpose of our study was to improve the patient's outcome by looking for the best diagnostic tools, secondly to improve radiotherapy resistance since about 50% of all cancer patients are treated with it. The fir st par t of our study will be per formed in Alkhatib center and the selection of that hospital was upon its highly sensitive diagnostic tools, in which PET/ CT scan was playing a major role to improve survival as shown in few repor ts in our study, and it’s the only safe diagnostic tool for a per son who has a metal fragments after injury in the war which increased the number of such patients in our country dur ing the last decade. This diagnostic tool is based on FDGin which we can define the tumor by using sugar more than normal tissue.
Bacteriocins : Ecology and Evolution
Microbes produce an extraordinary array of defense systems. These include bacteriocins, a class of antimicrobial molecules with narrow killing spectra, produced by bacteria. The book describes the diversity and ecological role of bacteriocins of Gram-positive and Gram-negative bacteria, presenting a new classification scheme for the former and a state-of-the-art look at the role of bacteriocins in bacterial communication. It discusses the molecular evolution of colicins and colicin-like bacteriocins, and provides a contemporary overview of archaeocins, bacteriocin-like antimicrobials produced by archaebacteria. Furthermore, various modeling (in silico) studies elucidate the role of bacteriocins in microbial community dynamics and fitness, delving into rock-paper-scissors competition and the counter-intuitive survival of the weakest. The book makes compelling reading for a multi-faceted scientific audience, including those working in the fields of biodiversity and biotechnology, notably in the human and animal health domain.
Baby milk in Syria
Breastfeeding is one of the most effective ways to ensure child health and survival. However, contrary to WHO recommendations, fewer than half of infants under 6 months old are exclusively breastfed. Infant formulas are liquids or reconstituted powders fed to infants and young children to serve as substitutes for human milk. Infant formulas have a special role in the diet because they are the only source of nutrients for some infants...
Applied Statistics Using SPSS, STATISTICA, MATLAB and R
The book provides a comprehensive coverage of the main statistical analysis topics important for practical applications such as data description, statistical inference, classification and regression, factor analysis, survival data and directional statistics.
Apoptotic pathways as targets for novel therapies in cancer and other diseases
The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients.
Agricultural biodiversity and biotechnology in economic development
The topics addressed in this book are of vital importance to the survival of humankind. Agricultural biodiversity, encompassing genetic diversity as well as human knowledge, is the base upon which agricultural production has been built, and protecting this resource is critical to ensuring the capacity of current and future generations to adapt to unforeseen challenges. Agricultural biodiversity underpins the productivity of all agricultural systems and is particularly important for poor and food-insecure farmers, who maintain highly diverse production systems in response to the marginal and risky production conditions they operate under. Understanding the importance of agricultural biodiversity in the livelihoods of the food insecure and enhancing its performance through the use of a variety of tools, including biotechnology, is a critically important issue in the world today
