الصفحة 27
الصفحة 27
Multi-Scale Approaches in Drug Discovery : From Empirical Knowledge to In silico Experiments and Back
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.
Multirate Statistical Signal Processing
This book introduces a statistical theory for extracting information from signals that have di?erent sampling rates. This new theory generalizes the conventional (deterministic) theory of multirate systems beyond many of its constraints.Furthermore,itallowsfortheformulationofseveralnewproblems such as spectrum estimation, time-delay estimation and sensor fusion in the realm of multirate signal processing. I have arrived at the theory presented here by integrating concepts from diverse areas such as information theory, inverse problems and theory of - equalities. The process of merging a variety of concepts of di?erent origin results in both merits and shortcomings. The former include the fresh and - di?erentiated view of an amateur, providing scope of application. The latter include a lack of in-depth experience in each of the original ?elds. Granted, this may lead to gaps in continuity, however it goes without saying that a complete theory can seldom be achieved by one person and in a short time.
Multi-processor system-on-chip 1 : Architectures
covers the key components of MPSoC: processors, memory, interconnect and interfaces. It describes advance features of these components and technologies to build efficient MPSoC architectures. All the main components are detailed: use of memory and their technology, communication support and consistency, and specific processor architectures for general purposes or for dedicated applications.
Multiplicative Invariant Theory
Multiplicative invariant theory, as a research area in its own right within the wider spectrum of invariant theory, is of relatively recent vintage. The present text offers a coherent account of the basic results achieved thus far.. Multiplicative invariant theory is intimately tied to integral representations of finite groups. Therefore, the field has a predominantly discrete, algebraic flavor. Geometry, specifically the theory of algebraic groups, enters through Weyl groups and their root lattices as well as via character lattices of algebraic tori.
Multiplication of RNA Plant Viruses
Biochemical studies on plant virus RNA replication have advanced considerably since 2000, primarily because of new genetic, molecular, biochemical, and enzymatic studies. Certain virus-encoded essential proteins, nucleotide sequence motifs, and RNA secondary structures are central to virus RNA replication, which has a number of stages.
Multiple Stars Across the H-R Diagram ; Proceedings of the ESO Workshop held in Garching, Germany, 12-15 July 2005
Stars show a marked tendency to be in systems of different multiplicity, ranging from simple binaries and triples to globular clusters with several 10,000's of stars. The formation and evolution of multiple systems remains a challenging part of astrophysics, and the contributions in this book report on the significant progress that had been made in this research field in the last years. The reader will find a variety of research topics addressed, such as the dynamical evolution in multiple stars, the effects of the environment on multiple system parameters, stellar evolution within multiple stars, multiplicity of massive stars, pre-main sequence and intermediate mass stars, multiplicity of low-mass stars from embedded protostars to open clusters, and brown dwarfs and extrasolar planets in multiples.
Multiple Sclerosis: Autoimmunity and Management
Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20–25 years in more than 30% of patients. The hallmark of MS is symptomatic episodes that occur months or years apart and affect different anatomic locations. Also, see the Autoimmune Disorders: Making Sense of Nonspecific Symptoms slideshow to help identify several diseases that can cause a variety of nonspecific symptoms. MS is diagnosed on the basis of clinical findings and supporting evidence from ancillary tests. Treatment consists of immunomodulatory therapy for the underlying immune disorder and management of symptoms, as well as nonpharmacologic treatments, such as physical and occupational therapy. Disease-modifying therapies have shown beneficial effects in patients with relapsing MS, including reduced frequency and severity of clinical attacks. These agents appear to slow the progression of disability and the reduce accumulation of lesions within the brain and spinal cord.
Multiple Integrals in the Calculus of Variations
From the reviews: "…the book contains a wealth of material essential to the researcher concerned with multiple integral variational problems and with elliptic partial differential equations. The book not only reports the researches of the author but also the contributions of his contemporaries in the same and related fields. The book undoubtedly will become a standard reference for researchers in these areas. …The book is addressed mainly to mature mathematical analysts. However, any student of analysis will be greatly rewarded by a careful study of this book."
Multiple Heterogeneous Unmanned Aerial Vehicles
Aerial robots can be considered as an evolution of the Unmanned Aerial Vehicles (UAVs). This book provides a quite complete overview of issues related to aerial robotics, addressing problems ranging from flight control to terrain perception and mission planning and execution. The major challenges and potentials of heterogeneous UAVs are comprehensively explored. It builds on the results of the European project COMETS, and highlights a number of key research topics in the area of UAV development, including communication, perception, teleoperation and decision making. The monograph emphasizes the current state of technology, the existing problems and potentialities of systems consisting of multiple UAVs which are heterogeneous in view of the different characteristics of the aerial vehicles, the different on-board payloads, and the different on-board information processing capabilities. The book also examines potential applications of UAVs and details a relevant application case: forest fire detection and monitoring.
Multiple Classifier Systems ; 7th International Workshop, MCS 2007, Prague, Czech Republic, May 23-25, 2007, Proceedings
These proceedings are a record of the Multiple Classifier Systems Workshop, MCS 2007, held at the Institute of Information Theory and Automation, Czech Academy of Sciences, Prague in May 2007. the workshop achieved its objective of bringing together researchers from diverse communities (neural networks, pattern rec- nition, machine learning and statistics) concerned with this research topic.
Multiple Classifier Systems ; 6th International Workshop, MCS 2005, Seaside, CA, USA, June 13-15, 2005, Proceedings
Constitutes the refereed proceedings of the 6th International Workshop on Multiple Classifier Systems, MCS 2005. This book contains papers that are organized in topical sections on boosting, combination methods, performance analysis, and applications. They exemplify the advances in the theory and applications of multiple classifier systems
Multiple Classifier Systems ; 2nd International Workshop, MCS 2001 Cambridge, UK, July 2-4, 2001 Proceedings
Driven by the requirements of a large number of practical and commercially - portant applications, the last decade has witnessed considerable advances in p- tern recognition. Better understanding of the design issues and new paradigms, such as the Support Vector Machine, have contributed to the development of - proved methods of pattern classi cation. However, while any performance gains are welcome, and often extremely signi cant from the practical point of view, it is increasingly more challenging to reach the point of perfection as de ned by the theoretical optimality of decision making in a given decision framework. The asymptoticity of gains that can be made for a single classi er is a re?- tion of the fact that any particular design, regardless of how good it is, simply provides just one estimate of the optimal decision rule.
Multiple Abstraction Hierachies for Mobile Robot Operation in Large Environments
This book focuses on the efficient performance of mobile robots through the use of multi-hierarchical symbolic representations of the environment. A mobile robot intended to perform deliberative actions must possess some symbolic representation of its workspace, but such representations of real environments usually become so large that should be conveniently arranged in order to facilitate and, in some cases, make possible their use. This book addresses all these issues considering symbolic multi-hierarchical structures. Such structures, based on the concept of abstraction, allow a robot to speed up its operation in large environments. Practical solutions tested on real robots (for instance, a robotic wheelchair for elder people) are provided.
Multiphase Reacting Flows : Modelling and Simulation
This book entitled ''Multiphase reacting flows: modelling and simulation'' contains the lecture notes of the CISM (International Centre for Mechanical Sciences) course held in Udine, Italy, on July 3-7, 2006, and it describes various modelling approaches for dealing with polydisperse multiphase reacting flows. A multiphase reacting system is characterized by the presence of multiple phases and in this book we focus on disperse multiphase systems, where one phase can be considered as a continuum, whereas the additional phases are dispersed in the continuous one. In other words, in this book we deal with multiphase systems constituted by particles, droplets or bubbles (i.e., solid particles suspended in a continuous liquid phase, liquid droplets in a gaseous phase, or gas bubbles in liquid.) The other important characteristic elements of the systems discussed in this book are the presence of one or more chemical reactions and the turbulent nature of the flow. The chemical reactions usually involve all the phases present in the system and might be responsible for the formation or disappearance of the disperse and/or continuous phases.
Multiphase Flow Dynamics 3 : Turbulence, Gas Absorption and Release, Diesel Fuel Properties
Volume 3 is devoted to selected Chapters of the multiphase fluid dynamics that are important for practical applications. The state of the art of the turbulence modeling in multiphase flows is presented. As introduction, some basics of the single-phase boundary layer theory including some important scales and flow oscillation characteristics in pipes and rod bundles are presented. Then the scales characterizing the dispersed flow systems are presented. The description of the turbulence is provided at different level of complexity: simple algebraic models for eddy viscosity, algebraic models based on the Boussinesq hypothesis, modification of the boundary layer share due to modification of the bulk turbulence, modification of the boundary layer share due to nucleate boiling. Then the role of the following forces on the matematical description of turbulent flows is discussed: the lift force, the lubrication force in the wall boundary layer, and the dispersion force.
Multiphase Flow Dynamics 2 : Thermal and Mechanical Interactions ; 3rd ed.
Multi-phase flows are part of our natural environment such as tornadoes, typhoons, air and water pollution and volcanic activities as well as part of industrial technology such as power plants, combustion engines, propulsion systems, or chemical and biological industry. The industrial use of multi-phase systems requires analytical and numerical strategies for predicting their behavior. In its third extended edition this book contains theory, methods and practical experience for describing complex transient multi-phase processes in arbitrary geometrical configurations. This book provides a systematic presentation of the theory and practice of numerical multi-phase fluid dynamics. In the present second volume the mechanical and thermal interactions in multiphase dynamics are provided. This third edition includes various updates, extensions, improvements and corrections.
Multiphase Flow Dynamics 1 : Fundamentals ; 3rd ed.
Multi-phase flows are part of our natural environment such as tornadoes, typhoons, air and water pollution and volcanic activities as well as part of industrial technology such as power plants, combustion engines, propulsion systems, or chemical and biological industry. The industrial use of multi-phase systems requires analytical and numerical strategies for predicting their behavior. In its third extended edition this monograph contains theory, methods and practical experience for describing complex transient multi-phase processes in arbitrary geometrical configurations, providing a systematic presentation of the theory and practice of numerical multi-phase fluid dynamics. This third edition includes various updates, extensions and improvements in all book chapters.
Multiphase Flow Dynamics 1 : Fundamentals ; 2nd ed.
In its second extended edition this monograph contains theory, methods and practical experience for describing complex transient multi-phase processes in arbitrary geometrical configurations. In the present first volume the fundamentals of multiphase dynamics are provided, as well as various interactive multimedia demonstrations on an accompanying CD-ROM.
Multiparadigm Programming in Mozart/Oz ; 2nd International Conference, MOZ 2004, Charleroi, Belgium, October 7-8, 2004, Revised Selected Papers
Oz's concurrency model yields simplicity and clarity (because Oz makes it easier to express complex programs with many interacting components), g- erality, and better interfaces (because the data?ow model automatically makes interfaces more lightweight). Constraint programming in Oz again yields simplicity and clarity (because theprogrammercanexpresswhatneedstobetrueratherthanthemorecomplex issue of how to make it true), and o?ers a powerful mathematical notation that is di?cult to implement on top of languages that do not support it natively. Mozart's distributed computing model makes for improved interfaces and eases the evolution of systems. In my own work, one of the most important concernsistobeabletoquicklyscaleupaprototypeimplementationintoalar- scale service that can run reliably on thousands of computers, serving millions of users.
Multiobjective Problem Solving from Nature : From Concepts to Applications
he book focuses on how MOEAs and related techniques can be used to solve problems, particularly in the disciplines of science and engineering. Contributions by leading researchers show how the concepts of multiobjective optimization can be used to reformulate and resolve problems in broad areas such as constrained optimization, coevolution, classification, inverse modelling and design. The book is distinguished from other texts on MOEAs in that it is not primarily about the algorithms, nor specific applications, but about the concepts and processes involved in solving problems using a multiobjective approach. Each chapter contributes to the central, deep concepts and themes of the book: evaluating the utility of the multiobjective approach; discussing alternative problem formulations; showing how problem formulation affects the search process; and examining solution selection and decision making.
