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الصفحة 2
الصفحة 2
Antisense RNA Design, Delivery, and Analysis
This volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Angiogenesis and Direct Myocardial Revascularization
In Angiogenesis and Direct Myocardial Revascularization, an interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis.
Anestetici locali in analgesia ostetrica : Il modello MLAC : dalla teoria alla pratica clinica = Local anesthetics in obstetric analgesia : The MLAC model : from theory to clinical practice
This monograph contains a detailed description of the MLAC method and its applications and an extensive and updated review of the most significant studies on the subject and their clinical implications. Studies that use the up-down sequential allocation method have made a significant contribution to clarifying numerous questions that the anesthetist asks himself every day in the delivery room and today rightly flank traditional studies representing, together with them, the primary source of updating and knowledge that are indispensable for good clinical practice based not only on experience but also on evidence and scientific rationale.
Analysis of Waiting-Time Data in Health Services Research
Analysis of Waiting-Time Data in Health Services Research asks critical questions linking waiting times to health care outcomes. Generously illustrated with charts and tables, the book places this type of data collection, analysis, and reporting firmly in the context of health services research, the study of outcomes of health care delivery to a population.
Alginates in drug delivery
Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers’ biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field.
Agricultural Biotechnology in China : Origins and Prospects
Building on a long tradition of agricultural advances, Chinese scientists have applied biotechnology techniques to develop hundreds of novel crop varieties suited to local farming conditions and challenges.Agricultural Biotechnology in China: Origins and Prospects is a comprehensive examination of how the origins of biotechnology research agendas, along with the effectiveness of the seed delivery system and biosafety oversight, help to explain current patterns of crop development and adoption in China. Based on firsthand insights from China’s laboratories and farms, Valerie Karplus and Dr. Xing Wang Deng explore the implications of China’s investment for the nation’s rural development, environmental footprint, as well as its global scientific and economic competitiveness.
Advances in pharmacokinetics and pharmacodynamics
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Adaptive dynamic programming for chemotherapy drug delivery
Focuses on the practical application of Adaptive Dynamic Programming (ADP) in chemotherapy drug delivery, taking into account clinical variables and real-time data. ADP's ability to adapt to changing conditions and make optimal decisions in complex and uncertain situations makes it a valuable tool in addressing pressing challenges in healthcare and other fields. As optimization technology evolves, we can expect to see even more sophisticated and powerful solutions emerge.
3D printing of pharmaceutical and drug delivery devices progress from bench to bedside
Discover the latest, fast-developing technology to help move towards more cost-effective, small-batch, decentralized manufacturing of personalized systems . 3D printing has revolutionized manufacturing. Its precision and flexibility have enabled the large-scale production of materials and devices too complex for conventional industrial manufacturing. This has been particularly revolutionary in the field of pharmaceutical production, where 3D printing is being integrated into the manufacture of both drugs and drug delivery devices. It has never been more important for industry professionals to understand this form of production.
Agile software engineering
This textbook presents the crucial issues in software engineering using the agile approach to software development - one of the mainstream paradigms for the management of software projects and one that is being applied more and more extensively.
Manual of clinical procedures in dentistry
Explains the core procedures in dentistry, how to do them, and the rationale that underpins them. Full of useful and easy-to-access information, it acts as a compendium of practical procedures in primary dental care, supporting students and dental practitioners in their daily professional and academic lives. This manual is a complete, practical guide to the delivery of effective, state of the art oral healthcare—the ‘what, when, and how’ of clinical practice. It compiles chapters written by expert clinicians on topics such as dental imaging, the management of dental pain, conscious sedation, operative dentistry, implant dentistry, oral medicine and surgery, paediatric dentistry, periodontics, prosthodontics, special care dentistry, dental trauma, aesthetic dentistry, and much more.
Biomimetic restorative dentistry ; Vol.1 : Fundamentals and basic clinical procedures
Takes the science of esthetic dental reconstruction to a new level both clinically and academically, and it offers all that a clinician could wish for in terms of indications and the classic clinical steps for tooth preparation, laboratory and CAD/CAM procedures, adhesive luting procedures, and maintenance. But above all, what makes this book so unique is the biomimetic principle—as such, restoring or mimicking the biomechanical, structural, and esthetic integrity of teeth is paramount. The core of this book centers on the application of the biomimetic principle in the form of bonded restorations using composite resins and ceramics, covering indications, treatment planning, diagnosis, tooth preparation and impression, laboratory and CAD/CAM procedures, final delivery, follow-up, maintenance, and repair. Written by a true master and artist, this book will undoubtedly inspire excellence in anyone who picks it up.
Biocompatible nanocomposites : From synthesis to applications
Presents a focused overview of biocompatible nanocomposites, emphasizing recent advancements in material design, synthesis techniques, and their expanding applications in biomedicine. It spans key areas such as regenerative medicine, drug delivery, cancer therapy, biosensing, diagnostic imaging, and vaccine delivery —illustrating how these materials are transforming modern healthcare. The book reviews widely used biomaterials including polycaprolactone, bioactive ceramics, and polymer-based hybrids, discussing their roles in cardiovascular, orthopedic, dental, maxillofacial, and ophthalmic applications.
Anesthesiology : New insights
Provides a comprehensive overview of current developments in anaesthesiology. The chapters : Solutions for Insufficient Epidural Analgesia for Planned Vaginal Birth and Interdisciplinary Emergencies in the Delivery Room, Anesthesia for Robotic Surgeries in Children, Anesthetic Management of Bronchoscopic Lung Volume Reduction, General Anaesthesia in the Context of Haemorrhagic Shock and Trauma, Anesthesiologic Management of Patients with Opioids or Psychoactive Substance Use, Fascial Plane Blocks, Considerations and New Perspectives of Locoregional Anesthesia in Dentistry, The Effect of Parental Anxiety on Postoperative Paediatric Cognitive Dysfunction.
Aligner systems in invisible orthodontics: basic concepts and clinical management
Describes the processes, techniques and biomechanics involved in providing aligner treatment for different types of malocclusions. It opens with an overview of the material characteristics and the basic concepts of aligner therapy including topics like biocompatibility and intraoral deterioration. The main part of the book is dedicated to the various types of aligners, the methods used in their application and the practical aspects of delivery. It is structured based on the type of malocclusion being managed giving the reader a systematic pattern and a practical way of progressing through the book. The book closes with a discussion of the scientific data available.
Airport Building Information Modelling
Details how Building Information Modelling is being successfully deployed in the planning, design, construction and future operation of the Istanbul New Airport, a mega-scale construction project incorporating a varying mix of infrastructures including terminals, runways, passenger gates, car parks, railways and roads. The book demonstrates how Airport Building Information Modelling (ABIM) is being used to: • facilitate collaboration, cooperation and integrated project delivery • manage subcontractors and eliminate cost over-runs • reduce waste on site and enhance overall quality • connect people in a virtual environment to encourage collaborative working • provide clients with an effective interface for lifecycle management including: design development, construction documentation, construction phases and BIM and Big Data Integration for future facilities management
Marketing ; 16th ed.
Expanded coverage on social responsibility and sustainability topics such as privacy, social entrepreneurship, diversity, equity, inclusion, and environmental impact. The 16e continues its real-world focus with “Marketing Matters,” “Making Responsible Decisions,” “Insights about me,” “Applying Marketing Metrics,” “Integration of the Customer Journey” and “Building your Marketing Plan” features throughout. Key marketplace changes related to the pandemic such as curbside pick-up, touchless payment, and delivery have been incorporated.
Managing Agile Business Technology : The Business and Technology Relationship Model in Practice
Describes in detail how the BTRM, combined with a focus on value creation and value delivery, will enable continuous change, in the context of current, emerging and future technologies. It illustrates the potential for real-time insight and control not previously considered and provides a wide range of information to plan an implementation, understand where AI can be applied, and its importance in the world of self-managing systems.
Learning at speed : How to upskill and reskill your workforce at pace to drive business performance
Learning at Speed is a practical book which brings together the best from lean and agile methodologies to show how they can be applied to learning and development (L&D) to improve individual and organizational performance. This provides a people development framework which can be used to deconstruct a learning strategy and optimise each element for improved results. It shows how to identify learning barriers and possible solutions, leverage company data to understand learning needs and how to assess the most effective learning resources and delivery channels.
Lean Architecture : Excellence in Project Delivery
Shows readers a path to improve their project delivery via the application of lean concepts and process management. Authors Michael Czap and Gregory Buchanan challenge readers to reexamine their approach to architectural practice and projects by presenting a unique and compelling alternative. Readers will learn to: Maximize the use of their resources to deliver superior results in less time / Minimize waste, cost, and inefficiency in their firm’s operations / Move between radically different project scales while retaining efficient and effective processes
