الصفحة 18
الصفحة 18
Evaluating evidence of mechanisms in medicine : Principles and procedures
This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness.
European Variations as a Key to Cooperation
This book offers a novel view on the benefits of a lasting variation between the member states in the EU. In order to bring together thirty very different European states and their citizens, the EU will have to offer more scope for variation. Unlike the existing differentiation by means of opt-outs and deviations, variation is not a concession intended to resolve impasses in negotiations; it is, rather, a different structuring principle. It takes differences in needs and in democratically supported convictions seriously
European Somalis' Post-Migration Movements : Mobility Capital and the Transnationalisation of Resources
Based on a qualitative study on migrants of Somali origin who have settled in Europe for at least a decade, this open access book offers a ground-breaking exploration of the idea of mobility, both empirically and theoretically. It draws a comprehensive typology of the varied “post-migration mobility practices” developed by these migrants from their country of residence after having settled there. It argues that cross-border mobility may, under certain conditions, become a form of capital that can be employed to pursue advantages in transnational social fields. The study sheds a different light on migrants who are often considered passive or problematic migrants/refugees in Europe, and demonstrates that mobility capital is not the prerogative of highly qualified elites: less privileged migrants also circulate in a globalised world, benefiting from being embedded in transnational social fields and from mobility practices over which they have gained some control.
European Guide to Power System Testing : The ERIGrid Holistic Approach for Evaluating Complex Smart Grid Configurations
This book provides an overview of the ERIGrid validation methodology for validating CPES, a holistic power system testing method. It introduces readers to corresponding simulation and laboratory-based tools, including co-simulation, real-time simulation, and hardware-in-the-loop. Selected test cases and validation examples are provided, in order to support the theory discussed.
Euro-Par 2007 Workshops : Parallel Processing ; HPPC 2007, UNICORE Summit 2007, and VHPC 2007, Rennes, France, August 28-31, 2007, Revised Selected Papers
Parallel and distributed processing , although within the focus of computer science research for along time ,is gainingmore and more importance in awidespectrum of applications. These proceedings aim to demonstrate the use of parallel and distributed processing concepts in diferent application felds, and attempt to spark interest in novel research directions to advance the embracing model of high-performance computing research in general. The objective of these workshops is to specifcally address researchers c- ing from university, industry and governmental research organizations and application-oriented companies, in order to close the gap between purely sentifc research and the applicability of the research ideas to real-life problems.
Ethnobotany and ethnopharmacology of medicinal and aromatic plants : steps towards drug discovery
Medicinal and aromatic plants are beneficial to human health. Plant-derived molecules possess biological activities that can be used to prevent many infectious diseases and metabolic disorders. Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants summarizes techniques and methods used to study the biological activities of plant-derived extracts and compounds to study ethnobotanical and ethnopharmacological features of medicinal and aromatic plants.
Ethical Dimensions of the Economy : Making Use of Hegel and the Concepts of Public and Merit Goods
This book reflects philosophically about the socio-political dimension of economics. Part I provides normative reflections on the economy: Section I reflects on the interconnections between the multiple discourses on the economy, section II presents Hegel's claim that the economic order is an ethical institution and defends his ontological view of the economy against the one of Adam Smith. Section III dialogues with economists about their concepts of public and merit goods. This section defends a Hegelian ontology of the economy through an analysis of technical concepts used by economists. Part II provides applications derived from the normative analysis: Section I presents the views of authors in different academic disciplines pointing to failures in late capitalism, in particular failures of American capitalism and section II asks the question: " What must one pay attention to in a transition from a command economy to a free market?" Section III draws attention to an overlap of ideas found in Catholic Social Thought and in the publications of some recent Nobel prize winners in economics (Buchanan, Sen, Stiglitz).
Estrogen Effects in Psychiatric Disorders
A number of studies, mostly focusing on estrogen replacement therapy in women, have reported beneficial actions of these hormones on various neurobiological and neuropathological parameters in health and disease. Recent research has focused on gender differences and there is increasing evidence that estrogens exert protective effects in schizophrenia. Hormonal fluctuations or lack of estrogen may increase the risk of depression among vulnerable women. Treatment of depression with estrogen may stabilize and restore disrupted homeostasis – as during post-partum, premenstrual, or perimenopausal conditions – and act as a psychomodulator to offset vulnerability to dysphoric mood when estrogen levels are significantly decreased, as in the case of postmenopausal women. Studies on the effect of estrogens on Alzheimer’s Disease are still rather controversial, they do, however, facilitate the hypothesis that estrogens may have a modifying effect on the onset and course of AD, at least in subgroups of patients.
Essentials of Dental Radiography and Radiology
Presents everything that an undergraduate dental student, postgraduate student or general dental practitioner needs to know in order to safely capture high-quality clinical images and accurately interpret their findings.
Ernst Zermelo : An approach to his life and work
This biography attempts to shed light on all facets of Zermelo's life and achievements. Personal and scientific aspects are kept separate as far as coherence allows, in order to enable the reader to follow the one or the other of these threads. The description of his personality owes much to conversations with his late wife Gertrud. The presentation of his work explores motivations, aims, acceptance, and influence. Selected proofs and information gleaned from unpublished notes and letters add to the analysis.
Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Environmental Security and Sustainable Land Use - with special reference to Central Asia
This book presents important aspects of environmental security and sustainable land use in general and in particular for Central Asia, i.e. the environmental consequences of climate change; sustainable land use and regional development; sustainable development in mountain and steppe regions; beyond borders: Transboundary Biosphere Reserve "Altai" as an approach for regional development; landscape planning as an integrative tool for sustainable development; challenges and threats for environmental stability in Central Asia. A final recommendation in the area of sustainable development and land use as well as the proceeding efforts towards the establishment of the Transboundary Biosphere Reserve "Altai" and the implementation of landscape planning were set in the book as some of the main results of the meeting.
Environmental Policy Instruments for Conserving Global Biodiversity
If you can believe, all things are possible to him who believes. —Mark 9:23 The current, unprecedented loss of global biodiversity as a result of anthropo genic interference in the world's ecosystems is affecting human well-being across the globe with increasing severity. It therefore represents a major chal lenge in international environmental policymaking. With the Convention on Biological Diversity (CBD), the community of states has recognized the in creasing importance of preserving biodiversity. Given the extensive context of biodiversity loss and preservation, this study focuses on two issues, which are at the center of the public discussion regarding the objectives of conservation and the sustainable use of biodiversity, and that are addressed by specific policy instruments. The first issue is the regulation of cross-border trade in genetic information and genetic resources. Here, the question is whether the commercial use of genetic information derived from bio diversity can create incentives for its preservation. The second issue involves the conservation of biodiversity through the protection of ecologically valuable eco systems from human use.
Entropy, Search, Complexity
The present volume is a collection of survey papers in the fields of entropy, search and complexity. They summarize the latest developments in their respective areas.More than half of the papers belong to search theory which lies on the borderline of mathematics and computer science, information theory and combinatorics, respectively. Search theory has variegated applications, among others in bioinformatics. Some of these papers also have links to linear statistics and communicational complexity.
Entrepreneurship, the new economy and public policy : Schumpeterian perspectives
Silicon Valley is the most salient example of high-tech industrial clusters. Public policy makers throughout the world would like to learn the secrets of Silicon Valley in order to build their own high-tech economies. The existing literature on ind- trial clusters, which traces back to Marshall (1920), focuses on the way in which ?rms bene?t from locating in a cluster; it suggests that once a cluster comes into existence However, a more important question is how to reach this critical mass in the ?rst place. In contrast to the literature, evidence suggests that entrepreneurs rarely move when they est- lish high-tech start-ups. This contradicts the notion that location choice analyses lead entrepreneurs to a high-tech cluster. A high-tech industrial cluster such as Silicon Valley is characterized by c- centrated entrepreneurship.
Enterprise Management with SAP SEM™
In order to make strategy happen there is a need for powerful management information systems. SAP focuses on the application of modern business administration concepts, e.g. Value Based Management, the Balanced Scorecard, the Management Cockpit or flexible planning methods. The book describes the methodology and implementation of a powerful tool for enterprise management. Practical examples show how SAP Strategic Enterprise Management/Business Analytics (SAP SEM/BA) can help to improve cross functional planning, reporting and analyzing. SAP SEM/BA is a leading edge IT-solution for top management and related departments in large enterprises and groups. It demonstrates the state of the art of modern management information and decision support systems.
Ensembles ordonnés finis : concepts, résultats et usages = Finite ordered sets : concepts, results and uses
The concepts of order, classification, storage are presented in many activities and human situations. The mathematical formalization of these notions first allowed the great development of the theory of lattices, then that of more general ordered structures, in particular those relating to discrete mathematics.
Ennio De Giorgi : Selected Papers
The book contains a selection of 43 scientific papers by the great mathematician Ennio De Giorgi (1928-1996), which display the broad range of his achievements and his entire intellectual career as a problem solver and as a proponent of deep and ambitious mathematical theories. All papers are written in English and 17 of them appear also in their original Italian version in order to give an impression of De Giorgi’s original style. The editors also provide a short biography of Ennio De Giorgi and a detailed account of his scientific achievements, ranging from his seminal paper on the solution of Hilbert’s 19th problem to the theory of perimeter and minimal surfaces, the theory of G-convergence and the foundations of mathematics.
Enhancing the Dissolution Rate of Atorvastatin by Solid Dispersion Technique
In the last few decades, solid dispersion (SD) technology had been studied as an approach to produce an amorphous carrier to enhance the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. The use of suitable carrier and methodology in the preparation of SDs play a significant role in the biological behavior of the SDs. Atorvastatin is a statin group HMG-CoA reductase inhibitor drug that is commonly used to adverse cardiovascular events and to lower blood total cholesterol and LDL-cholesterol. the solubility of atorvastatin in water is very low (0.1 mg mL− 1), which results in reduced bioavailability. In order to enhance its solubility, we have prepared solid dispersions (SDs) of atorvastatin at different drug: polymer ratios (1:2, 1:10, 1:20,1:25 and 1:40), using polyethylene glycol 6000 as polymer and different preparation methods (co-precipitate and melting methods) The characterization of the SDs was performed using differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) The solubility of AT was improved by the incorporation PEG6000.
Energy Justice Across Borders
This book unites the fields of energy justice and comparative philosophy to provide an overarching global perspective and approach to applying energy ethics. We contribute to this purpose in four sections: setting the scene, practice, applying theory to practice, and theoretical approaches.
