الصفحة 15
الصفحة 15
Circular entrepreneurship : Creating responsible enterprise
Investigation reveals enterprises small and large delivering a stimulating message, from changes in entrepreneurial mindsets to the inclusive use of new technologies and a push for innovation. Zucchella and Urban explore the novel concept of circular enterprise, showing how, with their capacity to innovate, these firms are becoming the most powerful actors of a new, sustainable social order.
Chinese Railways : Reform and Efficiency Improvement Opportunities
Although being huge by any measure, Chinese Railways are a bottleneck for economic growth in China. The state-owned enterprise returns a small profit but is severely capacity constrained and burdened with inefficiency. A comprehensive reform and efficiency improvement program needs to be developed in order to enable Chinese Railways to support further GDP growth in China. Application of industrial economics to the case of Chinese Railways suggests that moderate deregulation of e.g., the freight business could make Chinese Railways fit for future growth. Operational improvements need to complement this development, such as a redesign of the schedule or the introduction of value added services in the freight business. Based on interviews with Chinese experts, benchmarking with railways in the US, Germany, Russia, and Japan as well as broad coverage of Chinese-language sources, the book makes detailed recommendations on how to design a comprehensive turnaround program for Chinese Railways.
Child Protection in England, 1960–2000 : Expertise, Experience, and Emotion
Explores how children, parents, and survivors reshaped the politics of child protection in late twentieth-century England. Activism by these groups, often manifested in small voluntary organisations, drew upon and constructed an expertise grounded in experience and emotion that supported, challenged, and subverted medical, social work, legal, and political authority. New forms of experiential and emotional expertise were manifested in politics – through consultation, voting, and lobbying – but also in the reshaping of everyday life, and in new partnerships formed between voluntary spokespeople and media. While becoming subjects of, and agents in, child protection politics over the late twentieth century, children, parents, and survivors also faced barriers to enacting change, and the book traces how long-standing structural hierarchies, particularly around gender and age, mediated and inhibited the realisation of experiential and emotional expertise.
Chemokines and Viral Infection
This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
Chemical Genomics ; Vol.58 : Small Molecule Probes to Study Cellular Function
Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry.Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.
Chassins Operative Strategy in Esophageal Surgery
Chassin’s Operative Strategies in Esophageal Surgery offers the reader a succinct review of surgical techniques for disorders of the esophagus. Spanning from well-established legacy procedures to the most up-to-date minimally invasive approaches for GERD, this brilliantly illustrated atlas exclusively presents the theoretical basis of the operations as well as the strategies required to steer clear of common pitfalls. Educed from Chassin’s Operative Strategies in General Surgery.
Challenge In biologic drug delivery
Biologics are currently one of the most promising avenues for therapeutic interventions in conditions such as metabolic disease, ageing and inflammatory disorders, and for chronic ailments, oral delivery of such medicines has for years been recognised as an important goal. Despite decades of intensive research, oral delivery of biologics is only just starting to prove feasible. There has been much talk about the barriers to uptake of biologics, and indeed, one function of the intestine is to prevent, in one way or another, passage of unwanted materials across the gut, and yet, grams of biological agents both large and small pass across the intestinal cell wall every day. This review first describes the functioning of the gut under normal circumstances, then identifies the principle biological mechanisms, which have been harnessed successfully, to date, to achieve oral uptake, outlining the pros and cons of each approach.
Cerebral palsy
Cerebral palsy is a lifelong condition that affects the individual, family, and immediate community. Therefore, the goal of allowing the individual with cerebral palsy to live life with the least impact of the disability requires c- plex attention to the individual and the family. Furthermore, society needs to be sensitive and to accommodate individuals with disabilities by limiting architectural impediments and providing accessible public transportation and communication. The educational system provides the key means for helping the individual prepare to function in society to his or her maximum ability. In many ways, the medical care system probably has the least sign- icant role in preparing the child with cerebral palsy to function optimally in society. However, the medical care system is the place where parents first learn that their child has developmental issues outside the expected norm. It is almost universally the place where parents also expect the child to be made normal in our modern society. In earlier times, the parents would expect healing to possibly come from the doctor, but also they would place hope for healing in religion. As this belief in spiritual or miraculous healing has - creased, a significant font of hope has decreased for parents of young ch- dren with disabilities.
Celiac disease
Celiac Disease is a chronic small intestinal immune-mediated enteropathy caused by the ingestion of dietary gluten proteins in genetically susceptible individuals. CD is one of the most common autoimmune diseases, affecting around 1.4% of the population globally . Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options. Finding alternative diet and trying different lifestyle still under debates. However, complete exclusion of the gluten-containing food from the patient's diet is the only effective treatment to avoid the disease complications
Catastrophic Events Caused by Cosmic Objects
Many times all of us could hear from mass media that an asteroid approached and swept past the Earth. Such an asteroid or comet will inevitably strike the planet some day. This volume considers hazards due to collisions with cosmic objects, particularly in light of recent investigations of impacts by the authors. Each chapter written by an expert contains an overview of an aspect and new findings in the field. The main hazardous effects – cratering, shock, aerial and seismic waves, fires, ejection of dust and soot, tsunami are described and numerically estimated. Numerical simulations of impacts and impact consequences have received much attention in the book. Fairly small impacting objects 50 -100 m in diameter pose a real threat to humanity and their influence on the atmosphere and ionosphere is emphasized.
Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches
The cardiovascular system transports oxygen and nutrients to all parts of the body; therefore, any impediment to this system through, for example, a circulatory disorder, represents a serious threat to organs, tissues, and cells. Obstructive diseases of vessels with a diameter of more than 1 mm can be treated by conventional surgical and interventional approaches; however, blockages in small vessels with a diameter of less than 1 mm cannot be treated by conventional methods. As a consequence, therapeutic ang- genesis and vasculogenesis for the treatment of ischemic diseases have been widely studied in the last decade. These methods may contribute to the re pair of intractable cardiovascular diseases with a main vascular involvement in the body's smallest vessels. In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering.
Carbon monoxide in drug discovery, basics, pharmacology, and therapeutic potential
Carbon monoxide, one of the smallest organic natural molecules, is widely known for its toxicity. Formation of CO via incomplete combustion is a major contributing factor to accidental or intentional CO poisoning, leading to severe health consequences or death. In addition, CO is a by-product of tobacco smoking, and has been associated with some of the harmful effects of smoking. However, less known and probably far more important is the recognition of the essential physiological roles of CO as a signaling molecule in mammals. Against over more than a century of negative connotation, the last few decades have proven that CO possesses a multitude of physiological roles and therapeutic functions including regulation of the immune response, cellular proliferation, and control of cell survival. This concept is supported by the discovery that CO is produced by all cells and more so under conditions of stress. This book comprehensively summarizes key aspects of CO's endogenous roles, therapeutic functions, and challenges that we face in its development as a therapeutic agent. We hope this preface will provide a thread for reading this book and a birds-eye view of the landscape for understanding this field, and more importantly lay out the challenges ahead in understanding the detailed mechanisms of action of CO and in its development as a therapeutic agent.
Cancer
The last decade has seen a dramatic shift in anticancer drug research towards agents that aim to target selectively key regulatory and signaling processes known to drive tumorigenesis. A number of these newer agents have now been introduced into clinical practice. This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-nvasives. Each chapter aims to cover the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Calm : Interiors to nurture, relax and restore
Home should be a place to retreat from the everyday. Creating a home that instills a sense of calm will cocoon and protect us from the outside world, create a sense of wellbeing and make us feel truly nurtured. Calm will help you create a restful, restorative interior that draws you in and makes your shoulders drop the moment you walk through the door. Sally Denning first explores the essential foundations of a tranquil, comforting home: calming and harmonious colors, textiles, patterns, lighting, and decorative elements.
Burnt human remains : Recovery, analysis, and interpretation
Presents an in-depth multidisciplinary approach to the detection, recovery, analysis, and identification of thermally altered remains. Bridging the gap between research and practice, this invaluable one-stop reference provides detailed coverage of analytical techniques in forensic medicine and pathology, forensic anthropology, forensic odontology, and forensic chemistry and forensic biology.
Bridge design for economy and durability : Concepts for new, strengthened and replacement bridges
Describes a number of new or updated bridging concepts which were developed and s"Describes a number of new or updated bridging concepts which were developed and successfully applied during the author's forty years of close involvement with UK and international bridge design, construction, maintenance and research. The concepts mainly apply to the small/medium span range of bridges and viaducts and contribute to one or more of the following features: design and construction economy in both time and money / ease of inspection and minimum maintenance / ride quality and safety / good appearance / strengthening when required with minimum traffic disruption"
Brain Metastases
Brain metastases are the most dreaded complication of systemic cancer, affecting approximately 170,000 people a year, a far greater incidence than primary brain tumors. Advances in modern chemotherapy have led to an improved control of system cancers, often with agents that poorly penetrate the central nervous system, resulting in an increasing incidence of brain metastases. Traditional chemotherapy has had little impact on brain metastases. The main therapeutic option is radiation therapy, and in a small number of patients - surgery. However, refinements in all of these treatments offer some positive outcomes and an increased ability to stratify patients based on certain criteria.
Botox side effect and natural alternatives
Botox is a drug made from a toxin produced by the bacterium Clostridium botulinum. It's the same toxin that causes a life-threatening type of food poisoning called botulism. Doctors use it in small doses to treat health problems. Botox injections work by weakening or paralyzing certain muscles or by blocking certain nerves. The effects last about three to twelve months, depending on what you are treating...
Boss It : Control Your Time, Your Income and Your Life
In this invigorating and highly practical book, serial entrepreneur Carl Reader provides exactly the fire and guidance you need to get started. Designed to cut through the business jargon, this handy guide will take you through everything you need to establish and run your own business - from the mindset it takes to turn a dream into a plan, to the need-to-know practical stuff for running and growing a business.
Borderless Knowledge : Understanding the “New” Internationalisation of Research and Higher Education in Norway
this book analyses patterns of internationalisation comprising the national and supranational level, the level of higher education institutions and private companies, as well as the level of individual researchers and graduates. As a laboratory for studying internationalisation the book uses the case of Norway, a small knowledge system set in an open society, political system and economy. The case offers exceptionally good data on the developments in its research and higher education system that record changes over time and across the different parts and levels of a national knowledge system.
