الصفحة 15
الصفحة 15
Persistent Organic Pollutants in the Great Lakes
Brings together what is known about the major classes of these pollutants in the Great Lakes. Each chapter reviews our knowledge of the extent of contamination of the various parts of the Great Lakes ecosystem (air, water, sediment, fishes, birds, etc.), what is known about the trends over time of this contamination, and knowledge about the mechanisms by which these pollutants are mobilized in the lakes. Detailed information is presented on polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and dibenzofurans, pesticides, toxaphene, polychlorinated naphthalenes, polycyclic aromatic hydrocarbons, brominated flame retardants, and perfluoroalkyl acids. These reviews make this volume an invaluable resource for all those involved in environmental research, measurements, and decision making.
Percutaneous absorption : Drugs, cosmetics, mechanisms, methods
Supplies topics on: cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
Perception-based data processing in acoustics : Applications to music information retrieval and psychophysiology of hearing
The objective of the monograph is to provide novel insights into cognitive mechanisms underlying processing of sound and music in different environments. A solid understanding of these mechanisms is vital for numerous technological applications.
Peptidomics : Methods and strategies
Explores essential techniques and newly emerged applications used in the expanding field of peptidomics. The opening chapters describe sample preparation and basic techniques. Subsequent chapters delve into quantitative peptidomics, bioinformatics, deep learning approaches, non-human model organisms, and peptide toxins. The last section includes multiple chapters on applications of peptidomics for human clinical specimens. Written for the highly successful Methods in Molecular Biology series, chapters include overviews and introductions to their respective topics, lists of the necessary materials, reagents, and instrumentation, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Pediatric hematopoietic stem cell transplantation for pharmacists : The gold standard to practice
Addresses subjects such as stem cells and their differentiation mechanisms; aspects of embryonic and non-embryonic stem cells ; stem cell transplantation in pediatrics ; stem cell sources and related technical choices ; stem cell donors ; scheduling transplantations ; diseases and chemotherapy protocols that require stem cell transplantation ; stem cell homing ; engraftment and repopulation of stem cells in bone marrow; autologous stem cell transplantation in pediatrics ; allogeneic stem cell transplantation in pediatrics ; and indications for autologous and allogeneic pediatric stem cell transplantation. Further, it discusses pediatric graft-versus-host disease and the pharmacist ; antibacterial and antifungal prophylaxis ; detailed chemotherapy, conditioning and trials for pediatric stem cell transplantation ; conditioning granulocyte colony-stimulating factor (G-CSF) in pediatric stem cell transplantation ; analyzing prescriptions and programming a pediatric stem cell transplantation ; handling chemotherapy and adjuvant drugs for pediatric stem cell transplantation ; stem cell transplantation in children up to 1 year old ; and clinical pharmacy in pediatric stem cell transplantation.
Pattern Asterisms : A New Way to Chart the Stars
Orion is a familiar constellation. He even looks like a hunter – at least it’s easy to visualize his belt and sword.Since the very beginning of astronomy, people have looked up at the night sky and constructed patterns out of the almost random scattering of stars. The fact that the constellations are still used today reflects their usefulness in identifying bright stars in the rotating dome of the sky.Not only is this book a new and effective aid to navigating the night sky, it’s also the basis of a great group activity for star parties – guessing and visualizing entirely new star patterns.
Pathological basis of oral and maxillofacial diseases
A comprehensive guide for integrating pathology into a clinical setting. Presents the basic principles involved in disease mechanisms in an easy-to-understand way. By integrating recent advances in molecular, immunologic, and genetic understanding of oral disease, the book helps readers enhance their knowledge and its application in a clinical setting. This book is divided into nine sections, covering key topics such as inflammation, genetic diseases, and neoplasia, with contributions from over 50 international authors.
Past and Present Water Column Anoxia
Contains papers partly based on presentations by 60 scientists attending a NATO Advanced Research Workshop on Past and Present Water Column Anoxia in Sevastopol, Ukraine. They address the entire range of oxygen-deficient conditions and reflect the complexity of the issues governing the formation and persistence of such conditions.
Paclitaxel : Sources, Chemistry, Anticancer Actions, and Current Biotechnology
Provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and anticancer activities. In addition, biotechnological methods, including cell cultures, the use of bioreactors and metabolic engineering strategies to improve Paclitaxel production are also discussed. The book discusses topics such as mechanisms of action against cancer, novel forms of Paclitaxel for an effective cancer treatment, strategies for enhancing its bioavailability, and the application of nanocarriers for its delivery and chemotherapy of cancer.
P.Y. Galperin's Development of Human Mental Activity : Lectures in Educational Psychology
This book introduces the legacy of Piotr Galperin to a wider audience of researchers, educators and psychologists. Previous translations of Galperin’s work present only some aspects of his conceptual thinking; however, his main contribution to the general, genetic and pedagogical psychology as a unique holistic and systemic approach to studying of psychological phenomena and processes, mechanisms of their formation and development, is still quite unknown in most parts of the world.
Oxidative Damage to Nucleic Acids
This book provides an up-to-date coverage of selected topics in the area of nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.
Oxidants and Antioxidant Defense Systems
Oxidative stress is one of the major symptoms accompanying physiological functions and numerous diseases. Oxidants and free radicals are connected with diseases such as cancer, diabetes, infectious, cardiovascular and neurodegenerative diseases and also in the aging process itself. Therefore, comprehensive knowledge of the underlying mechanisms of oxidant and free radical production and the defence against this permanent threat to cells is important for the understanding of many physiological and pathophysiological processes. This book overviews the basic mechanisms of oxidant formation and antioxidant defences. In addition, the formation of oxidants and their detoxification, the damage of macromolecules and the major repair and removal systems will be highlighted.
Orientation and Navigation in Vertebrates
Reviews all major models and hypotheses concerning the mechanisms supposed to underlie the process of navigation in vertebrates.It covers data on all major model groups of vertebrates studied in the context of animal navigation, such as migratory birds, homing pigeons, sea turtles, subterranean mammals and some migratory fish species. Some other – less studied – groups, e.g., whales, have also been touched.The first part of the book describes different sources of navigational information, with their specific navigational mechanisms known or supposed to be employed by animals for navigational goals. The second part discusses possible functions of these mechanisms in different vertebrates and in the context of different navigational tasks, ranging from short-range navigation, often performed by animals within as small an area as several square meters, to long-distance global-scale migrations performed by many birds and some sea turtles during their lifespan.
Organizational Principles for Multi-Agent Architectures
Key topics of this book:- a framework for multi-agent system design, based on human organizational notions and principles for distributed intelligent systems design- "Coordination mechanisms" in the form of "Problem Solving Methods", which can assist "Managers" and agent engineers in reasoning about coordination- the "Five Capabilities (5C) model" which is a conceptual framework bases on a generalization of typical agent intelligence competences, such as "autonomy", "interaction", "pro-activeness" and "reactiveness"- a multi-agent architecture capable of (semi)automatic reuse of Problem Solving Methods- "ontology-based communication", in which the meaning and intention of message contents in agent communication is specified in "message content ontologies".
Organ on a chip for drug development and disease modeling
“Organ-on-a-chip” systems integrate microengineering, microfluidic technologies, and biomimetic principles to create key aspects of living organs faithfully, including critical microarchitecture, spatiotemporal cell–cell interactions, and extracellular microenvironments. This creative platform and its multiorgan integration recapitulating organ-level structures and functions can bring unprecedented benefits to a diversity of applications, such as developing human in vitro models for healthy or diseased organs, enabling the investigation of fundamental mechanisms in disease etiology and organogenesis, benefiting drug development in toxicity screening and target discovery, and potentially serving as replacements for animal testing.
Orbital Tumors : Diagnosis and Treatment
In order to provide the most recent developments in the science of orbitology, Orbital Tumors explores the latest developments in medical genetics, molecular genetics, and immunosurveillance mechanisms of neoplasia. The occurrence of multiple, malignant neoplasms in retinoblastoma have been included to apply molecular concepts to clinical practice related to orbital tumors. In the realm of clinical practice for orbital pathology, no development has been more influential than the revolution in imaging techniques, including ultrasonography, computerized tomography, and magnetic resonance methods. The implications of these improvements in diagnostic capabilities are fully explored and explained in Orbital Tumors. The text also includes diagnostic advances in immunohistochemistry, flow cytometry, gene microarray, and the polymerase chain reaction. These are summarized in a separate chapter on orbital biopsy.
Oral Mucosa in Health and Disease : A Concise Handbook
Designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically. In this book, recognized experts in the field provide up-to-date coverage of all aspects of the structure and function of the oral mucosa, reflecting important recent advances in knowledge, including at the molecular level.
Oral Infections and General Health : From Molecule to Chairside
Provides a wide-ranging update on the associations between oral infections and general health. Detailed consideration is given to the underlying mechanisms or pathways linking oral infections to general health, including metastatic spread of infection from the oral cavity as a result of transient bacteremia, metastatic injury from the effects of circulating oral microbial toxins, and metastatic inflammation caused by immunological dysfunction induced by oral microorganisms.
Oral Health and Herbal Medicine
Oral health loss is one of the major problems existing all over the world and is one of the top causes of death when unmanaged. The oral cavity is home to numerous pathogenic microorganisms, some of which are responsible for the progression and development of various systemic diseases such as cancer, diabetes and myocardial infarction. Worldwide, 60–90% of school children and nearly 100% of adults have dental cavities, often leading to pain and discomfort. There are implications for the global economy as well, due to the continuous burden of investing resources to maintain oral hygiene. Not surprisingly, developing countries are disproportionally affected. There is thus an urgent need to develop economical solutions for the treatment of oral diseases.
Oral biofilms and modern dental materials : advances toward bioactivity
Provides an up-to-date perspective on oral biofilms and dental materials, equipping readers with a sound understanding of their mutual interactions. Experts from across the world comprehensively describe the main strategies that can be followed when designing modern bioactive and biomimetic dental materials, bearing in mind the goal of reducing the occurrence of pathological conditions such as secondary caries and peri-implantitis. The background to the book is the rapid expansion in the use of nanotechnologies and modern techniques to achieve levels of performance of dental materials that were unthinkable even a few years ago.
