الصفحة 13
الصفحة 13
Biosimilars : Regulatory, clinical, and biopharmaceutical development
Provides a comprehensive overview of the biosimilar regulatory framework, the development process and clinical aspects for development of biosimilars. The development path of a biosimilar is just as unique as a development path of a new drug, tailored by the mechanism of action, the quality of the molecule, published information on the reference product, the current competitive environment, the target market and regulatory guidance, and most importantly, the emerging totality of evidence for the proposed biosimilar during development.
Bioresonance therapy and telemedicine
The aim of our research project is to highlight the Medical application of Physics although we as Pharmacologist remain often focused on the value of Pedications to resolve any disease however we noticed Some complicated medical problems such as antibiotic Resistance where we cannot find any responsive Chemical therapy therefore we referred to the history of Bio resonance therapy however we were also concerned To report the medical value by following some patients Whom were treated and to analyze the mechanism in Which this therapy is effective, and for which diseases And we also hope that this established device for Targeting Bacteria, viruses can hold a hope for patients Who are diagnosed with Corona, there is a proof of Principle for that hypothesis since the scientist Rife has Invented this therapy by interference destruction wave Which could destroy specifically this bacteria upon its Frequency wave without possible
Biomedical applications and toxicity of nanomaterials
Covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.
Biomarkers for alzheimer’s disease drug development
Helping to accelerate Alzheimer’s disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer’s disease field are performed.
Biomarkers as targeted herbal drug discovery : A pharmacological approach to nanomedicines
Looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Reviews the literature on inflammatory biomarkers in the treatment of diseases Looks at the development of herbal drug discovery based on biomarkers Explores emerging concepts of nanomedicines for herbal drug delivery Takes an interdisciplinary approach, with application to disciplines related to medical, pharmaceutical, biotechnological, Ayurvedic, Unani and biomedical engineering fields
Bioinformatics tools for pharmaceutical drug product development
Presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. And include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall.
Biocombinatorial approaches for drug finding
Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource
Behavioral pharmacology of the cholinergic system
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Basis and Treatment of Cardiac Arrhythmias
Incorporating the information related to mechanisms and treatment of cardiac arrhythmia, this book discusses genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These approaches and implementations of anti-arrhythmic therapy derive from many decades of research.
Banks and shareholder value : An overview of bank valuation and empirical evidence on shareholder value for banks
In the German banking sector, management is continually increasing its focus on shareholder interests. This can be seen in the ambitious profitability targets set by management in this sector. Some municipalities are also putting increasing pressure on Landesbanks and saving banks, as members of the largest German banking group, to create greater financial value.
Bacterial signal transduction : Networks and drug targets
Interactions among different TCSs enable one system to respond to multiple signals, which is important for bacteria to minutely adjust themselves to complex environmental changes. Such interactions are found or predicted in various bacteria in this book. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these develop› ments have been put together in this book, Bacterial Signal Transduction: Networks andDrug Targets. This book Offers an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs.
B2B eCommerce : Basics, Business Models and Best Practices in Business-to-Business Online Trade
Covers the basics of business-to-business (B2B) eCommerce, where similar principles of customer targeting can be observed as in B2C eCommerce. Gerrit Heinemann highlights the specifics and business models of B2B eCommerce, analyzes the digital challenges and shows the consequences and opportunities for online sales in B2B. Recognised best-practice examples illustrate how successful B2B eCommerce can work and which risks have to be considered.
Axonal branching and recovery of coordinated muscle activity after transsection of the facial nerve in adult rats
Facial nerve surgery inevitably leads to partial pareses, abnormally associated movements and pathologically altered reflexes. The reason for this "post-paralytic syndrome" is the misdirected reinnervation of targets
Autonomous Robots and Agents
This book deals with the theoretical and methodological aspects of incorporating intelligence in Autonomous Robots and Agents. Challenges faced in the real world to accomplish complex tasks, which require collaborative efforts, and methods to overcome them, are detailed. Several informative articles deal with navigation, localization and mapping of mobile robots, a problem that engineers and researchers are grappling with all the time.This edited volume is targeted to present the latest state-of-the-art methodologies in Robotics. It is a compilation of the extended versions of the very best papers selected from the many that were presented at the 3rd International Conference on Autonomous Robots and Agents (ICARA 2006) which was held at Palmerston North, New Zealand from 11-14 December, 2006. Scientists and engineers who work with mobile robots will find this book very useful and stimulating.
Automated machine learning : Methods, systems, challenges
This book presents the first comprehensive overview of general methods in Automated Machine Learning (AutoML), collects descriptions of existing systems based on these methods, and discusses the first series of international challenges of AutoML systems. The recent success of commercial ML applications and the rapid growth of the field has created a high demand for off-the-shelf ML methods that can be used easily and without expert knowledge. However, many of the recent machine learning successes crucially rely on human experts, who manually select appropriate ML architectures (deep learning architectures or more traditional ML workflows) and their hyperparameters. To overcome this problem, the field of AutoML targets a progressive automation of machine learning, based on principles from optimization and machine learning itself.
Assessment of the fate and effects of toxic agents on water resources
Like all limited and vulnerable resources, water has become one of the potential targets of terrorists. Coastal lagoons are especially vulnerable as they are densely populated centers of commerce and/or tourism. This volume addresses the basic scientific concepts that must be integrated by decisionmakers to minimize damages and optimize recovery operations in the aftermath of such an attack. Scientists from many disciplines including water resource management, hydrodynamics, aquatic ecology and social science combine their expertise in an effort to assess and model emergency scenarios for coastal lagoon systems. This case study uses existing numerical models such as-EFCD, WASP and AQUATOX are used to demonstrate how to optimize rapid response and decision-making
Aspects of mathematical modelling : Applications in science, medicine, economics and management
The construction of mathematical models is an essential scientific activity. Mathematics has long been associated with developments in the exact sciences and engineering, but more recently mathematical modelling has been used to investigate complex systems that arise in many other fields. The contributors to this book demonstrate the application of mathematics to modern research topics in ecology and environmental science, health and medicine, phylogenetics and neural networks, theoretical chemistry, economics and management. The reader will find some review papers outlining current research directions in hot topics such as pattern formation and applications to medicine, and more targeted research papers on current developments in the various disciplines included.
Aspects of Illegal, Unreported and Unregulated Fishing in the Southern Ocean
Overfishing threatens the viability of high seas living resources. Furthermore, controls to prevent overfishing are inadequate. Illegal, Unreported and Unregulated (IUU) fishing is a product of overfishing and affects all marine fisheries. Southern Ocean fisheries have been particularly targeted by IUU fishing. The efforts of the Convention for the Conservation of Antarctic Marine Living Resources Commission and the Australian government to adopt complementary measures to deter IUU fishing in the Southern Ocean form the basis of this study, although the examination is conducted following a comprehensive review of the legal and other factors contributing to the development of IUU fishing as well as the applicable international law.
Asias debt capital markets : Prospects and strategies for development
The book has three parts. Part I describes the characteristics and historical origins of these markets. Part II examines the contemporary bond markets and shows how they contribute to general welfare, describes the relationship between the banking sector and capital markets, and assesses prospects for reform in Asia's governmental and corporate debt markets. Part III explains the micro-level impediments and obstacles that must be the first targets of any reform efforts, provides an appraisal of attempts at regional cooperation to stimulate structural reform, and lastly contributes proposals to accelerate the growth and reach of bond markets throughout Asia.
Arum palaestenium in cancer therapies
Cancer is a very complicated sequence of disease conditions progressing gradually with a generalized loss of growth control.1–3 There were only a few options of cancer treatment for patients for many decades which include surgery, radiation therapy, and chemotherapy as single treatments or in combination.4,5 But recently, many pathways involved in cancer therapy progression and how they can be targeted has improved dramatically, with combinatorial strategies, involving multiple targeted therapies or “traditional” chemotherapeutics, such as the taxanes and platinum compounds, being found to have a synergistic effect.6 New approaches, such as drugs, biological molecules, and immune-mediated therapies, are being used for treatment.
