الصفحة 12
الصفحة 12
Cyclin Dependent Kinase 5 (Cdk5)
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.
Cutaneous Lupus Erythematosus
Lupus erythematosus is a chronic inflammatory autoimmune disease characterized by a wide spectrum of manifestations with a variable evolution. There has been a long-standing need for a book with a unifying concept on the cutaneous manifestations of this disease. The book is based on multidisciplinary knowledge and is written by leading clinicians and scientists. It provides not only a comprehensive description of the vast variety of cutaneous abnormalities but also a synthesis of the relationship between cutaneous and systemic changes, including chapters on classification and clinical aspects, pathogenesis and pathologic features, and treatment and management of lupus erythematosus.
Current Topics in Complement
Complement has been regarded as a pivotal effector arm of the innate immune response. Many scientists convened at the Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics, to discuss the advances in this field. This volume represents a collection of topics discussed during the conference.
Current Perspectives in microRNAs (miRNA)
In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.
Current Concepts in Autoimmunity and Chronic Inflammation
The ethiopathologies of autoimmune diseases are complex. A broad variety of cell types and gene products are involved. This book explores clinical and experimental evidence suggesting that the importance of an individual factor changes during the course of the disease.
CtBP Family Proteins
The Ctbp family proteins are multifunctional. They predominantly function as transcriptional corepressors in the nucleus by recruiting various histone modifying enzymes such as histone deacetylases, histone methylases and a histone demethylase. This book is a comprehensive monograph on the Ctbp family proteins.
Cough : Pathophysiology, diagnosis and treatment
This book provides an updated and comprehensive overview of cough, while opening new perspectives for their treatment and management. It enables readers to not only discover new physiologic features and mechanisms but also to gain an in-depth understanding of the diagnostic workup of cough, still one of the most frequent and challenging symptoms in daily medical practice. The book also provides insights into cough’s features and pathogenesis, as well as into pharmacologic and non-pharmacologic treatments. The most frequent causes of chronic cough (asthma, postnasal drip, gastroesophageal reflux and chronic hypersensitivity syndrome) and different types of pediatric cough are also explored.
Cortical Deficits In Schizophrenia : From Genes to Function
Opens with a chapter by Paul Harrison highlighting the several convergence points among the diverse schizophrenia-related genes. This is followed by chapters reviewing several different specific genes, including Neuregulin, DISC-1, dysbindin, and Homer, among others, and by several chapters presenting information on physiological cortical processes that could be affected by those genes. These include glutamatergic, GABAergic and cholinergic neurotransmission.Current hot topics in schizophrenia research are also highlighted in the book. A concept that is gaining strength in the field, the chapters in this book summarize the current state of affairs in schizophrenia pathophysiology, with a consideration of genetic elements that may contribute to it. Cortical Deficits in Schizophrenia: From Genes to Function will prove a useful tool for those interested in a better understanding of schizophrenia. Even if more predisposing genes (not included in this book) become identified, the work laid out here will prove critical for assigning a functional (or dysfunctional) role to those genes. Although this is a fast-evolving field, the information and concepts covered in this book will likely be useful for years to come.
Coronaviruses : Methods and Protocols
Aims to describe a variety of techniques that reflects the wide range of research currently performed in the field of coronavirology, and begins with an overview of current understandings of coronavirus replication and pathogenesis to introduce specialists and non-specialists to the field. The rest of the book is divided into several sections of chapters beginning with those that describe identification, diagnosis, and study of the evolution of coronaviruses. The next few chapters discuss the preparation of cells and organ cultures useful in propagating coronaviruses and titration techniques, as well as techniques for analyzing virus functions that require purification of the viruses. The next chapters describe two commonly used reverse genetics techniques for coronaviruses, and techniques detailing identification of cellular receptors, binding profiles of viral attachment proteins, and virus-cell fusion. The final chapters cover a broad spectrum of techniques to identify virus-host protein-protein interactions, confirm the functional role of these proteins in virus replication, study host cell responses through genome-wide or pathway-specific approaches, and visualize virus replication complexes. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Coronavirus Replication and Reverse Genetics
This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.
Cornea and External Eye Disease : Corneal Allotransplantation, Allergic Disease and Trachoma
The 8 recurring volumes of the "Essentials in Ophthalmology" series cover the most recent developments in one of eight subspecialties in Ophthalmology.
Contrast Agent and Nephropathy
Diagnostic tests such as MRIs (magnetic resonance imaging), CT (Computed tomography) scans and angiograms are routinely used because they provide important information about many diseases or injuries and can help in diagnosis and treatment. In many cases, the use of a contrast dye is necessary to enhance these tests, but sometimes these dyes can either lead to kidney problems, or cause problems in patients with kidney disease. There are two rare but serious disorders associated with contrast dyes and the kidneys: contrast induced nephropathy (CIN) and nephrogenic systemic fibrosis (NSF).
Congenital Diseases and the Environment
"In recent years, increasing attention and resources have been brought to bear on the relationship between the environment and congenital diseases. These diseases were previously thought to be mostly due to genetic causes. Even though the importance of genes as factors in causation is accepted, environmental factors seem to be implicated just as strongly. This book explores some further concepts that have arisen from more recent perceptions of environmental effects and their possible interactions with living systems. Discussion and presentation of old and novel ideas is targeted at developing a more holistic and united perception of the interaction between congenital diseases and the environment. Amongst the topics discussed are: -effects of prenatal exposure to toxic chemicals -intra-uterine exposure to drugs -effects of endocrine disrupters -environmental risk and sex ratio in newborns -surveillance of environmental impact-research and policy."
Conditional Mutagenesis : An Approach to Disease Models
Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.
Computational genetics and genomics : Tools for understanding disease
The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiological or pathological responses among inbred mouse strains, thus facilitating more rapid genetic discovery
Colorectal Cancer : Evidence-based Chemotherapy Strategies
The clinician is challenged to keep up with the rapidly changing landscape and the rapidly emerging data that shape the options for treatment today and tom- row. In this text, leaders in the management of colorectal cancer review the current literature that has led us to where we are today. Critical evaluations of the data are offered, and evidence-based recommendations are made.
Color Atlas of Chemical Peels
This book is the first atlas on chemical peels, representing the state of the art in this field. It is a fully illustrated text, becoming an ideal reference tool for dermatologists dealing with cosmetology. It is a practical and simple guide: in the first part the peeling techniques are displayed in a step-by-step manner with an exhaustive text supporting the illustrations; in the second part different diseases are discussed in their pathogenesis and treatment options.
Cold Region Atmospheric and Hydrologic Studies. The Mackenzie GEWEX Experience: Vol.2: Hydrologic Processes
This book presents decade-long advances in atmospheric research in the Mackenzie River Basin in northern Canada, which encompasses environments representative of most cold areas on Earth. Collaborative efforts by a team of about 100 scientists and engineers have yielded knowledge entirely transferable to other high latitude regions in America, Europe and Asia. Emphases are placed on the investigation of processes (including storm genesis, precipitation, moisture and energy fluxes and frost), and the improvement and application of a suite of models and remote sensing to enhance the assessment of climate variability and water resources.
CO-ENZYME Q10
Coenzyme Q10 (CoQ10) is a fat-soluble compound that is synthesized by the body and can be obtained from the diet. Co-Q10 plays a central role in mitochondrial oxidative phosphorylation and the production of adenosine triphosphate (ATP). It also functions as an antioxidant in cell membranes and lipoproteins. Endogenous synthesis and dietary intake provide sufficient C0- Q10 to prevent deficiency in healthy people, although coenzyme Q10 concentrations in tissues decline with age. Oral supplementation of coenzyme Q10 increases coenzyme Q10 concentrations in plasma and lipoproteins. Oral high-dose co- Q10 is usually effective to treat mitochondrial disorders that are caused by mutations in coenzyme Q10 biosynthetic genes.
Clusia : A woody neotropical genus of remarkable plasticity and diversity
Clusia is the only dicotyledonous tree genus with crassulacean acid metabolism (CAM), and in some cases all variants of CAM can be expressed in one given species. These unique features as well as Clusia's extreme flexibility have put it in the limelight of international research. The studies presented in this volume embrace anatomy, morphology and plant architecture, phytogeographical distribution and community ecology, phylogeny and genetic diversity, physiology and metabolism, physiological ecology and functional diversity, circadian rhythmicity and biological timing. Covering all aspects of tree biology, this richly illustrated volume is an invaluable source of information for any plant scientist.
