الصفحة 12
الصفحة 12
Electrical Diseases of the Heart : Genetics, Mechanisms, Treatment, Prevention
Electrical Diseases of the Heart is a thorough clinical reference on the current status of cardiac electrophysiological disease,emphasizing common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology, and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science.
Economic Analyses of the European Patent System
Stefan M. Wagner analyses problems associated with institutional changes (duration of patent examination and opposition mechanisms), the expansion of the patentable subject matter and organizational challenges for industrial patentees. The study is based on the empirical analysis of large scale datasets on European patents and employs advanced multivariate methods such as semi-parametric and panel-data regression methods.
Ecology of Riparian Forests in Japan : Disturbance, Life History, and Regeneration
It presents the dynamics and mechanisms that govern the coexistence of riparian tree species, tree demography, the response to water stress of trees, and the conservation of endangered species, and focuses on natural disturbances, life-history strategies, and the ecophysiology of trees. Because many riparian landscapes have been degraded and are disappearing at an alarming rate, the regeneration of the remaining riparian ecosystems is urgent. With contributions by more than 20 experts in diverse fields, this book offers useful information for the conservation, restoration, and rehabilitation of riparian ecosystems that remain in world streams and rivers.
Dynamic pricing and automated resource allocation for complex information services : Reinforcement learning and combinatorial auctions
This book develops allocation mechanisms that aim to ensure an efficient resource allocation in modern IT-services. The author presents two methods, both of which using the users’ willingness-to-pay to control the allocation process. The author generates a method to calculate dynamic resource prices.
Durability of reinforced concrete structures
Reinforced concrete structures corrode as they age, with significant financial implications, but it is not immediately clear why some are more durable than others. This book looks at the mechanisms for corrosion and how corrosion engineering can be used for these problems to be minimized in future projects. Several different examples of reinforced concrete structures with corrosion problems are described and the various life enhancement solutions considered and applied are discussed. The book includes a chapter on the effectiveness of corrosion monitoring techniques and questions why the reality is at odds with current theory and standards.
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug and Alcohol Abuse : A Clinical Guide to Diagnosis and Treatment
Gives professionals and students across the health and mental health disciplines a working knowledge of drug-related pathology, beginning with pharmacology, drug mechanisms, and genetic factors. This title features clinical/emergency orientation suited to both chronic misuse and acute situations.
DNA Methylation, Epigenetics and Metastasis
Provides an outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. This book describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour
DNA Methylation : Basic Mechanisms
The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is not well understood. The stability, inheritability, and developmental flexibility of these patterns point to a major role that these patterns appear to play in determining structure and function of the genome.
DNA Conformation and Transcription
the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Distributed Event-Based Systems
Event-based architectures inherently decouple system components. Event-based components are not designed to work with specific other components in a traditional request/reply mode, but separate communication from computation through asynchronous communication mechanisms via a dedicated notification service.
Discovering Biomolecular Mechanisms with Computational Biology
In this anthology, leading researchers present critical reviews of methods and high-impact applications in computational biology that lead to results that also non-bioinformaticians must know to design efficient experimental research plans. Discovering Biomolecular Mechanisms with Computational Biology also summarizes non-trivial theoretical predictions for regulatory and metabolic networks that have received experimental confirmation. Discovering Biomolecular Mechanisms with Computational Biology is essential reading for life science researchers and higher-level students that work on biomolecular mechanisms and wish to understand the impact of computational biology for their success.
Direct Democracy in Europe : Developments and Prospects
The initiative and referendum process offers extra channels of participation and can serve as an important supplementary institution in representative democratic systems. This first volume of the new series Direct Democracy in Modern Europe features sixteen systematic and broadly empirical approaches to the study of modern direct democracy within the context of European politics including - system contexts and effects of the initiative and referendum process - theoretical approaches and basic values in modern direct democracy - the quality and institutional design of direct democratic mechanisms - aspects of information and communication - institutional performance and economic effectiveness - transnational challenges and the development of direct democracy in Europe
Dipeptidyl Aminopeptidases : Basic Science and Clinical Applications
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.
Diffuse matter from star forming regions to active galaxies : A volume honouring John Dyson
In this volume dedicated to him, introductory reviews to a number of the key processes and to the sources themselves are given by leading experts. The mechanisms in which the multi-component natures of media affect their dynamics receive particular attention, but the roles of hydromagnetic effects are also highlighted.
Diastolic Heart Failure
This book addresses the epidemiology, pathophysiologic mechanisms, diagnostic methods, treatment and prognosis. It also gives an analysis of specific problems, related to coronary artery disease, arterial hypertension, diabetes, hypertrophic and restrictive cardiomyopathies, and constrictive pericarditis.
Designing Organizations : 21st Century Approaches
The design of organizations has been an ongoing concern of management theory and practice over the past several decades. Over this time, there has been little change in the fundamental theory, principles and concepts of Organization Design (OD). Recently organizational life has changed dramatically with the advent of: new communication systems, adaptive mechanisms, information technology, knowledge management systems, innovation processes and more. This book systemically examines these developments and their impact on OD with contributions from leading scholars in the area. Also featured in the book are the practical issues with implementing OD in organizations. The individual chapters are organized into five sections: (1) Putting Contingency Theory in its Place, (2) Focus on Individuals Who Make up the Organization, (3) Innovation Processes and Organization Design, (4) Adaptation and Technology, and (5) Design for Performance. Each chapter examines aspects of the book’s threefold theme: (1) core issues in organization design, (2) emerging theoretical perspectives in OD, and (3) new developments and directions in OD. A special feature of each chapter is: 1) implications for theory, and 2) implications for practice.
Design of Hybrid Structures : Where Steel Profiles Meet Concrete
Focuses on design approaches for concrete structures reinforced in an unconventional way by steel profiles. It explains force transfer mechanisms of steel profiles and oncrete interfaces, and an analysis of the characteristics of hybrid structures, including slendercomponents. Several types of hybrid designs are addressed: walls and columns with several embedded steel profiles, connections strengthened by steel profiles between steel and composite or reinforced concrete components, including the specific case of shear keys connecting deep beams or flat slabs to columns. The transition zones in partly reinforced concrete and partly composite columns are also covered.
Dermatopathology
The book describes the principles of histopathologic patterns in selected acquired skin diseases, together with short clinical descriptions and case reports. The underlying, or possible underlying, mechanisms are elucidated, and controversial concepts are discussed. To facilitate the understanding of underlying mechanisms, the first chapters of the book comprise summaries of basic histology of lymphatics and blood vessels, relevant parts of general pathology, immunology, and molecular cell biology.
Deployment and operation of complex software in heterogeneous execution environments : The SODALITE approach
This book provides an overview of the work developed within the SODALITE project, which aims at facilitating the deployment and operation of distributed software on top of heterogeneous infrastructures, including cloud, HPC and edge resources. The experts participating in the project describe how SODALITE works and how it can be exploited by end users. While multiple languages and tools are available in the literature to support DevOps teams in the automation of deployment and operation steps, still these activities require specific know-how and skills that cannot be found in average teams. The SODALITE framework tackles this problem by offering modelling and smart editing features to allow those we call Application Ops Experts to work without knowing low level details about the adopted, potentially heterogeneous, infrastructures. The framework offers also mechanisms to verify the quality of the defined models, generate the corresponding executable infrastructural code, automatically wrap application components within proper execution containers, orchestrate all activities concerned with deployment and operation of all system components, and support on-the-fly self-adaptation and refactoring.
