الصفحة 12
الصفحة 12
Drug discovery with privileged building Blocks : Tactics in medicinal chemistry
Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book.
Drift-Driven Design of Buildings : Mete Sozen’s Works on Earthquake Engineering
Summarizes the most essential concepts that every engineer designing a new building or evaluating an existing structure should consider in order to control the damage caused by drift (deformation) induced by earthquakes. It presents the work on earthquake engineering done by Dr. Mete Sozen and dozens of his collaborators and students over decades of experimentation, analysis, and reconnaissance. Many of the concepts produced through this work are integral part of earthquake engineering today. Nevertheless, the connection between the concepts in use today and the original sources is not always explained.
Drawing imagining building : Embodiment in architectural design practices
Drawing Imagining Building focuses on the history of hand-drawing practices to capture some of the most crucial and overlooked parts of the process. Using 80 black and white images to illustrate the examples, it examines architectural drawing practices to elucidate the ways drawing advances the architect’s imagination.
Drawing Architecture : The beginner's guide to drawing and painting buildings
A comprehensive and practical guide full of advice and inspiration for anyone wishing to capture the beauty of the urban landscape. The wonderful thing about drawing buildings is that, wherever you travel around the globe, you will never be short of subjects to inspire you. From the most elaborate of Renaissance cathedrals, through to the humble garden shed, you will always be able to practise your skills and learn a few techniques in the process. This hands-on and inspirational book will encourage you to meet the exciting challenges of drawing and painting buildings using a variety of media and a wide range of techniques, including pencil, pen, graphite powder, watercolour, water-soluble pencils and Indian ink. As you work through this book, you will look at materials and their qualities then move on to explore how to put these materials to best use when drawing specific types of building. You will be led gently through levels of learning, with easy and more challenging exercises progressing your knowledge and developing your skills. As the book is divided into discrete sections, you can dip in to a particular type of building that you wish to draw, and use the information and illustration provided, while extended teaching exercises take you through the way the author approaches composing and completing a drawing.
Doors : History, repair and conservation
Guides you through the function, history, development, care, repair and conservation of doors by chapter authors who are experts in their field. This book offers depth and range of detail from dating and archaeology right through to the surveying, recording, engineering and curation of the door, its furniture and the part of the building into which it is set.
Doormaking : Materials, Techniques, and Projects for Building Your First Door
Starts first by addressing the fundamentals: the basics of good design and proper construction technique, the pros-and-cons of common materials including wood and sheet goods, interior and exterior finishes, hardware and the fine points of hanging doors. Once those key elements are covered, it offers project chapters that walk the reader step-by-step through the construction of eight essential doors, explaining design and material choices in specific contexts, tool options and other considerations. The first four projects are easly accessible to a beginner while the the remaining projects offer up some more challenging details for the intermediate woodworker. Also included are sidebars containing amusing anecdotes and mistake stories each delivering tips as well as details for hanging a door and an inspiring gallery of doors that are sure to inspire.
Do Smart Adaptive Systems Exist? : Best Practice for Selection and Combination of Intelligent Methods
This book is intended as a reference and a guide summarising and focusing on best practices when using intelligent techniques and building systems requiring a degree of adaptation and intelligence. Another attractive feature of the book is that it brings together experts from neural network, fuzzy, machine learning, evolutionary and hybrid systems communities who will provide their views on how these different intelligent technologies have contributed and will contribute to creation of smart adaptive systems of the future.
DNA Computing Models
This book emphasizes computational methods to tackle central problems of DNA computing, such as controlling living cells, building patterns, and generating nanomachines.
Distributed network systems : From concepts to implementations
This textbook covers both theoretical and practical aspects of distributed computing. It describes the client-server model for developing distributed network systems, the communication paradigms used in a distributed network system, and the principles of reliability and security in the design of distributed network systems. Based on theoretical introductions, the book presents various implementation strategies and techniques for building distributed network systems, including examples in TCP/IP communications, the use of remote procedure call and remote method invocation techniques, and the development of web-based applications, distributed databases, and mobile computing systems.
Disordered Materials : An Introduction
This self-contained text introduces the physics of structurally disordered condensed systems at the level of advanced undergraduate and graduate students. Among the topics are the geometry and symmetries of the structural units used as building blocks of extended structures, the various kinds of disorder, the phenomenology and the main theories of the glass transition, the structure of amorphous systems and the techniques to investigate it, the evolution of system's structure with its size (clusters) and the presence of orientational order in the absence of translational order (quasicrystals). In the second edition, the treatment of the mode coupling theory of the glass transition has been enlarged and connects now to a new section on collective excitations in disordered systems. Special attention has been devoted to nanometer-sized disordered systems, with emphasis on cluster-assembled materials. Questions of what governs the occurrence and stability of quasicrystals, the features of the amorphous to quasicrystal transformation and its reverse transition are discussed. The conditions leading to nano-quasicrystalline phases of technological interest are examined. Throughout the text relevant recent experimental and theoretical results are discussed so as to give readers insight into the currently most vibrant research topics.
Digitization of healthcare data using blockchain
Gives a detailed description of the integration of blockchain technology for Electronic Health Records and provides the research challenges to consider in various disciplines such as supply chain, drug discovery, and data management. he aim of the book is to investigate the concepts of blockchain technology and its association with the recent development and advancements in the medical field. Moreover, it focuses on the integration of workflow strategies like NLP, and AI which could be adopted for boosting the clinical documentation and electronic healthcare records (EHR) usage by bringing down the physician EHR data entry. Also, the book covers the usage of smart contracts for securing patient records. Digitization of Healthcare Data Using Blockchain presents the practical implementations that deal with developing a web framework for building highly usable healthcare applications, a simple blockchain-powered EHR system.
Digital transformation of the design, construction and management processes of the built environment
This book focuses on the development of methods, interoperable and integrated ICT tools, and survey techniques for optimal management of the building process.
Digital Technologies in Construction Engineering : Selected Papers
Includes the latest advances, innovations, and applications in the field of construction engineering, as presented by researchers and engineers at the Digital Technologies in Construction Engineering conference, held in Belgorod, Russia, on June 8-9, 2021. It covers highly diverse topics, including industrial and civil construction, building materials; environmental engineering and protection; sustainability; structure safety and special construction structures. The contributions, which were selected by means of a rigorous international peer-review process, highlight numerous exciting ideas that will spur novel research directions and foster multidisciplinary collaborations.
Digital Libraries : International Collaboration and Cross-Fertilization; 7th International Conference on Asian Digital Libraries, ICADL 2004, Shanghai, China, December 13-17, 2004, Proceedings
The International Conference on Asian Digital Libraries (ICADL) is an annual international forum that provides opportunities for librarians, researchers and experts to exchange their research results, innovative ideas, service experiences and state-- the-art developments in the field of digital libraries. Building on the success of the first six ICADL conferences, the 7th ICADL conference hosted by the Shanghai Jiao Tong University and the Shanghai Library in Shanghai, China aimed to further strengthen the academic collaboration and strategic alliance in the Asia- Pacific Region in the development of digital libraries.
Digital libraries : Implementing strategies and sharing experiences ; 8th International Conference on Asian digital libraries, ICADL 2005, Bangkok, Thailand, December 12-15, 2005, Proceedings
Constitutes the proceedings of the 8th International Conference on Asian Digital Libraries, ICADL 2005. This book is organized in topical sections on concepts and models for digital library systems, case studies in digital libraries, digital archives and museums, multimedia digital libraries, digital libraries for community building, and more
Digital Human Modeling ; 1st International Conference, ICDHM 2007, Held as Part of HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings
Theis book includes human aspects of design and use of computing systems.It covers the entire field of Human-Computer Interaction, addressing major - vances in knowledge and effective use of computers in a variety of application areas. It also contains thematic area of Digital Human Modeling, Shape and Movement Modeling and Anthropometry, Building and Applying Virtual Humans, Medical and Rehabilitation Applications, Industrial and Ergonomic Applications
Diagrid structures : systems, connections, details
Diagrids are load-bearing structures made of steel diagonal grids. They were first used in the great buildings of the turn of the millennium, such as the Swiss Re Tower in London ("The Gherkin") and the Hearst Magazine Tower in New York City. Dagrids owe their ensuing popularity not only to their stunning aesthetic value, but also to their very tangible benefits: lateral loading capacity, a massive saving of material, a significant gain in open, usable floor area, and increased flexibility. At its opening in 2014, the Leadenhall Building in London will be the first skyscraper without a bearing inner core-thanks to a diagrid structure.
Diabetes drug notes
Diabetes is becoming more common in both older and younger generations and in keeping with this escalation in cases, there are an ever increasing number of drugs and drug classes that are suitable to treat hyperglycaemia. In a unique blend of diabetes practice, clinical pharmacology, and cardiovascular medicine, Diabetes Drug Notes describes the principles of clinical pharmacology with regards to diabetes prescribing. Each drug class for the treatment of diabetes is covered in detail, along with the effect on the cardiovascular and renal systems caused by each drug. Building upon the success of their "Drug Notes" series for Practical Diabetes and their "Drugs for Diabetes" series in the British Journal of Cardiology, the team of experts focuses on the glycaemic management of type 1 and type 2 diabetes, with other effects of antidiabetic drugs covered as well.
Developmental State Building : The Politics of Emerging Economies
This book modifies and revitalizes the concept of the ‘developmental state’ to understand the politics of emerging economy through nuanced analysis on the roles of human agency in the context of structural transformation. In other words, there is a revived interest in the ‘developmental state’ concept. The nature of the ‘emerging state’ is characterized by its attitude toward economic development and industrialization. Emerging states have engaged in the promotion of agriculture, trade, and industry and played a transformative role to pursue a certain path of economic development. Their success has cast doubt about the principle of laissez faire among the people in the developing world. This doubt, together with the progress of democratization, has prompted policymakers to discover when and how economic policies should deviate from laissez faire, what prevents political leaders and state institutions from being captured by vested interests, and what induce them to drive economic development.
Development of geopolymer from pond ash-thermal power plant waste : Novel constructional materials for civil engineers
Demonstrates how to utilize fly ash/pond ash (waste materials from thermal power plants) to produce a novel material called 'Geopolymer' (GP). Red mud, slags, etc., are mixed with fly ash to produce GP with enhanced strength. As shown in a few European countries, GP can replace cement, and some permanent structures constructed with GP are now appearing in a few advanced countries. GP, and geopolymer concrete, is considered suitable for the construction of roads, buildings, etc., and will eventually, fully or partially, replace cement.
