الصفحة 1
الصفحة 1
Oculoplastic Surgery Atlas : Cosmetic Facial Surgery
The previous volume in this series covered reconstructive eyelid surgery. This volume presents many aspects of facial cosmetic surgery, including blepharoplasty, endoscopic forehead surgery, rhytidectomy, and other related procedures. Future volumes will pr- ent facets of lacrimal and orbital surgery.
Nuucleic acids in medicinal chemistry and chemical biology : Drug development and clinical applications
Delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders : from Genes to Therapeutics
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Novel Carrier Systems for Targeted and Controlled Drug Delivery
Presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers.
Non-viral Gene Therapy: Gene Design and Delivery
The development of gene medicine based on the concept of molecular therapy has opened new medical horizons. Among the many techniques in gene medicine, gene design and delivery are especially significant in clinical applications. This book presents state-of-the-art information on non-viral gene-delivery techniques, covering a broad spectrum of disciplines that include chemistry, molecular biology, cell biology, and pharmacokinetics
Nonlinear Time Series Analysis in the Geosciences : Applications in Climatology, Geodynamics and Solar-Terrestrial Physics
This book presents recent developments in nonlinear time series which have been motivated by present day problems in geosciences. Modern methods of spatio-temporal data analysis, time-frequency analysis, dimension analysis, nonlinear correlation and synchronization analysis and other nonlinear concepts are used to study emerging questions in climatology, geophysics, solar-terrestrial physics and related scientific disciplines. This volume collects contributions of some of the world's leading experts in geoscientific time series analysis.
Neuronal cell death : Methods and protocols
Covers comprehensive methods on ways to assess structural and ultrastructural changes in the mitochondria, cytoskeleton, and microglia using state-of-the-art microscopy techniques including super-resolution imaging, electron microscopy, and ultra-high field MRI. The chapters in this book cover topics such as analysis of neurodegeneration in the post-mortem characterization of preclinical animal models, in vivo modeling in cell death in different model systems and brain organoids, single cell clonal analysis using Mosaic Analysis with Double Markers in genetic mouse models, and genome and proteomic methods for analysis of mRNA dynamics and quantitation of targeted peptides.
Neuroimmune Pharmacology
This exciting new textbook, Neuroimmune Pharmacology, reflects the history and vision of the Society on NeuroImmune Pharmacology and of the Society’s official publication, the Journal of Neuroimmune Pharmacology. All three represent deliberations arising from a relatively young, interdisciplinary, and dynamic field of research, which have major translational implications for neurodegenerative, neuroinflammatory, neuropsychiatric diseases, and infections of the nervous system. They all demonstrate the synergistic value of integrating the parts: Neuroscience, Immunology, and Pharmacology. The extraordinary accomplishment of Neuroimmune Pharmacology is its comprehensive nature.
Neuroendocrine cells and peptidergic innervation in human and rat prostrate
Introduction The prostate causes a signi?cant number of medical problems in the adult male, and the lower urinary tract symptoms are accepted as an unavoidable consequence of male aging. Most of these symptoms are mainly due to clinical benign prostatic hyperplasia (BPH), which is the most frequent benign tumor in the male, in- pendent of race or culture. On the other hand, cancer of the prostate shows an increasing incidence, being the second leading cause of death in men, after lung cancer.
Neural Networks and Sea Time Series : Reconstruction and Extreme-Event Analysis
This book, a careful blend of theory and applications, is an excellent introduction to the use of ANN, which may encourage readers to try analogous approaches in other important application areas. Researchers, practitioners, and advanced graduate students in neural networks, hydraulic and marine engineering, prediction theory, and data analysis will benefit from the results and novel ideas presented in this useful resource.
Natural poisons and venoms: Plant toxins : Polyketides, phenylpropanoids and further compounds
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natriuretic Peptides : The Hormones of the Heart
The rapid knowledge in the field of neuro-humoral regulation of cardiovascular pathophysiology is changing the picture of current diagnosis and treatment of cardiac patients. The emerging conceptual revolutionary idea is that heart acts not as a pump, merely, but as a "gland", that is as a regulator of circulatory homeostasis and salt-water balance. Cardiovascular pathophysiology has to be written, indeed, on this basis: this physiology textbook gives an up-to-date description of the complexity and novelty of actual knowledge, with all its potential clinical implications.
NASH and Nutritional Therapy
This collection of research and clinical findings on nonalcoholic steatchepatitis (NASH) and nutritional therapy contains significant new findings in several fields . As NASH frequently causes liver cirrhosis, the nutritional aspects of its treatment are discussed . Other areas covered include nonalcoholic fatty liver, the role of leptin in the pathogenesis of NASH, restricted diets and exercise therapy, mammalian targets of the peptide rapamycin, and genetic factors influencing the development of NASH.
Nanoparticle-Based Drug Delivery in Cancer Treatment
Discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Focuses on : Recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Material platforms that establish NPs and both localized and controlled gene silencing The most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment The most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells
Multiplication of RNA Plant Viruses
Biochemical studies on plant virus RNA replication have advanced considerably since 2000, primarily because of new genetic, molecular, biochemical, and enzymatic studies. Certain virus-encoded essential proteins, nucleotide sequence motifs, and RNA secondary structures are central to virus RNA replication, which has a number of stages.
Multiple Testing Procedures and Applications to Genomics
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. The methods are applied to a range of testing problems in biomedical and genomic research, including the identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments.
Multidetector-Row CT of the Thorax
With the advent of multidetector-row technology, excitement has returned to computed tomography. Not only can we now image faster and with better resolution than ever before; more importantly, the development of sophisticated image acquisition techniques has enabled us to venture into areas previously considered to be beyond the scope of CT imaging. The knowledge, experience, and vision of a host of renowned international experts in cutting-edge thoracic applications of multidetector-row CT are condensed within this book. The result is a critical, comprehensive review of the novel opportunities, but also the new challenges, brought about by the development of ever-faster CT acquisition techniques.
Multidetector-Row CT Angiography
Multidetector-row CT has dramatically improved the results of computed tomography in all clinical applications, but its beneficial impact has been most striking in vascular imaging. The simplicity of acquisition and the wide availability of equipment make this modality especially suitable for routine clinical application. In this book the basic aspects of multidetector-row CT angiography are comprehensively reviewed. Individual chapters are included on technical principles, image processing techniques and contrast agent administration. All clinical applications are then discussed in depth, with lucid descriptions of the examination technique for particular clinical indications and of the findings that characterize specific diseases. Limitations and advantages in comparison with other imaging modalities are considered. A large number of high-quality black and white and color illustrations help to explain the clinical findings.
Multidetector-Row Computed Tomography : Scanning and Contrast Protocols
Multidetector-row computed tomography (MDCT) has advanced the approach to diagnostic assessment of many pathologies and now plays an integral role in imaging of both abdominal and cardiovascular diseases. The possibility to acquire diagnostic images with shorter scan duration, longer scan ranges, and/or thinner sections, MDCT has facilitated the opening of new horizons, such as interventional MDCT and functional imaging in stroke and oncology. In addition, advanced postprocessing techniques now permit high quality volumetric imaging in combination with maximum intensity projections, volume rendering, curved planar reformations and multiplanar reconstructions. This volume gathers contributions by internationally renowned specialists in the field who, through presenting their clinical experience, provide a thorough overview not only of MDCT and its practical applications, but also of workflow management in everyday clinical practice. Focussing on scanning and contrast protocols, the current advantages and disadvantages of non-enhanced vs. enhanced MDCT are discussed, along with insights into likely future developments. The volume represents an up-to-date source of technical and practically-oriented clinical information which should prove of great benefit to all who wish to improve or consolidate their knowledge and expertise in MDCT.
Mucins : Methods and protocols
Explores the latest advancements in mucin research. The chapters in this book are organized into 8 parts and cover a wide range of topics such as mucin extraction, isolation, physicochemical property analysis, and experimental methods. The chapters also discuss the origins of mucins in jellyfish, feces, saliva and salivary glands, bronchi, stomach, and cervical tract; organic synthesis of peptides glycosylated at specific sites; analysis of mucin gene expression and methylation-specific electrophoresis of genes; imaging of mucin networks by AFM; and experimental methods using supported molecular matrix electrophoresis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
