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الصفحة 4
الصفحة 4
Asymmetric Cell Division
Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
Artificial intelligence in drug design
Looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future.
Arid Dune Ecosystems: The Nizzana Sands in the Negev Desert
Sand dune dynamics plays a key role in many arid deserts. This volume provides a synthesis of a specific sand dune ecosystem, the Nizzana site in the Negev Desert. Describing its climate and geophysical/geochemical properties of soils, geological history, flora and fauna, and past/present land-use patterns, it elucidates ecological and geomorphological processes and their interrelations, based on long-term monitoring, in situ experiments and satellite imagery. Particular attention is drawn to the impact of the topsoil biological crust in controlling water availability at local/regional scales. The interdisciplinary approach adopted in this case study offers a good example of a highly complex and dynamic system, which could easily be applied to other sandy ecosystems.
Anti-viral metabolites from medicinal plants
Covers general concepts of anti-viral metabolites, classifications, ethnopharmacology, chemistry, clinical and preclinical studies focusing on different medicinal plants against various types of viral infections. Various plants have been used in medicine since ancient times and are known for their strong therapeutic effects. The book will describe potential antiviral properties of medicinal plants against a diverse group of viruses, and provide an insight to the potential plants possess for broad-spectrum antiviral effects against emerging viral infections.The book aims to target a broad audience including virologists, molecular biologist, microbiologist and scientists working with natural products as well as researchers, students, healthcare experts involved in pharmaceutical and medical field.
Antimalarial natural products
Begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type.
Antibiotic pharmacokinetic : Pharmacodynamic considerations in the critically Ill
Provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
Analysis file of drug-induced lung injury : expert opinion for analysis of big data
Describes the pathologic conditions of drug-induced lung injuries, monitoring strategies, and guides on how to interpret the evidence. It also dives into particular drugs that caused the disorder, such as EGFR inhibitors, anti-EGFR antibodies, mTOR inhibitors, proteasome inhibitors, immune checkpoint inhibitors, neoangiogenesis inhibitors, and other molecular targeted drugs. It outlines the analysis and interpretation of the post-marketing survey on surveillance of each drug for inducing pulmonary lesions presenting diffuse haziness. The data and analysis from this survey are valuable since a guideline is yet to be established due to limited clinical evidence and cases. As new drugs are developed, establishing treatment and event management is crucial.
Analgesia
Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use.
An introduction to medicinal chemistry
Providing an introduction to medicinal chemistry, this resource covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug
An introduction to generative drug discovery
Describes the state‑of‑the‑art methods and applications for de novo design of drug candidates using generative chemistry models as well as the ethical aspects of this technology. It will provide a foundation for those new to the field as well as those that may already have some experience of its utility. With contributions from scientists in both academia and industry ‘Introduction to Generative Drug Discovery’ may represent one of the earliest if not the first book to focus on this topic.
Alzheimers Disease : Advances in genetics, molecular and cellular biology
Alzheimer’s Disease: Advances in Genetics, Cellular and Molecular Biology provides exciting, comprehensive and up-to-date summaries of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of AD. The studies and advances described in this volume will help to accelerate the process of rational drug discovery and soon serve to extend and enhance the mental health and lifespan of our burgeoning elderly population.
Alternative medicines for diabetes management : Advances in pharmacognosy and medicinal chemistry
Apart from diet and exercise, the strategic use of different classes of prescribed or non-prescribed xenobiotic compounds for the restoration of euglycemic levels in the body is well known. The ongoing rivalry between the recommended usage of allopathic medicines versus ayurvedic remedies has encouraged many researchers to focus their studies on thoroughly isolating and characterizing the extracts from different parts of plants and then evaluating their relative activities via in vitro, in vivo and in some cases clinical studies.
Alkaliphiles : Genetic properties and applications of enzymes
The pioneering work of Dr. Koki Horikoshi on the discovery, research and applications of alkaliphilic bacteria are described here in their entirety. The isolation, distribution and taxonomy of alkaliphilic microorganisms as well as their cell structure and physiology are discussed for a basic understanding of these entities. The molecular biology and genome sequencing of some alkaliphilic bacterial strains are also presented. Part II of the volume focuses on enzymes of alkaliphiles and their applications. These include alkaline proteases, starch-degrading enzymes and numerous others. Some of these enzymes are currently in wide commercial use as laundry detergent additives and in wastewater treatment. Alkaliphiles are a relatively recent field of research that will no doubt provide avenues to a wide range of further discoveries and applications for a new generation of workers in bioscience and technology.
Alicyclobacillus : Thermophilic Acidophilic Bacilli
Soft drinks with pHs lower than 4. 0 are subjected to minimum pasteuri- tion at 65 °C for 10 min as required by the Japanese Food Sanitation Law. Not only pathogenic bacteria but most spore-forming bacteria are unable to grow at this low pH condition, and thus reports of microbial spoilage in pasteurized acidic soft drinks are rare. Since 1982, when the spoilage of aseptically packed apple juice was - tributed to a new type of acidophilic spore-forming bacteria in Germany, a succession of similar complaints regarding other fruit juice concentrates and their products has been received. In the beginning, the bacteria were classified in the genus Bacillus, but later, in 1992, the new genus Ali- clobacillus was proposed owing to their characteristic cellular membranes containing omega-alicyclic fatty acids. A group of Alicyclobacillus strains, responsible for the tainting of fruit juices, was then described as A. a- doterrestris in 1999. They are acidophilic and grow preferably at around pH 4. 0. They are thermophilic and grow better at temperatures above 40 °C. This indicates that we might have been missing them by our or- nary methods of bacterial detection at pH 7. 0 and 35 °C.
AJCC Atlante per la stadiazione dei tumori maligni = Atlas for the Staging of Malignant Tumors
he atlas contains over 400 specially created black and white illustrations describing the anatomical extent of the malignant tumor in the primary site (T), regional lymph nodes (N) and distant metastases (M) for various sites, including the head and neck area, the digestive system, the thorax, the musculoskeletal system, the soft tissues, the breast, the urinary system and the genital system. Each illustration provides precise and detailed descriptions designed to clarify the crucial anatomical structures and to provide the reader with an immediate view of the progressive extension of the disease. The most important anatomical structures are identified by specific definitions.
AI in clinical medicine : A practical guide for healthcare professionals
A Practical Guide for Healthcare Professionals is the definitive reference book for the emerging and exciting use of AI throughout clinical medicine. AI in Clinical Medicine: A Practical Guide for Healthcare Professionals is divided into four sections. Section 1 provides readers with the basic vocabulary that they require, a framework for AI, and highlights the importance of robust AI training for physicians. Section 2 reviews foundational ideas and concepts, including the history of AI. Section 3 explores how AI is applied to specific disciplines. Section 4 describes emerging trends, and applications of AI in medicine in the future.
Aesthetic Facial Surgery
Rhytidoplasty is a palliative procedure in which face wrinkles are surgically removed to promote a more youthful appearance.The first sections focus on the surgical planning, including psychological considerations, preparation of the patient and anatomical and biochemical changes caused by the aging process. It also describes the surgical anatomy of the forehead, face, neck and eyelids. The third section provides a comprehensive overview of the basic techniques of facelift with details of refined surgical approaches for each segment of the face and neck. It highlights liposuction techniques, lipoinjection as well as transference of stem cells, showing their importance in reshaping the facial contours. It addresses both the treatment of soft tissue and craniofacial bone structures to improve the aesthetics of the face. The next sections present the final scars after face-lifting, minimally invasive procedures as complementary approaches during rhytidoplasty and the associated procedures during rhytidoplasty. The last section discusses postoperative care.
Advances in pharmacokinetics and pharmacodynamics
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Advances in Healthcare Technology : Shaping the Future of Medical Care
This book describes valued contributions of technology for improving hospital and home healthcare, and gives a perspective on how they will influence critical aspects of future medical care. It provides an overview and discussion of trends, presents the state-of-the-art of important research areas, and highlights recent breakthrough results in selected fields, giving an outlook on game-changing developments in the coming decades.
Adipose-derived stem cells : Methods and protocols
Discusses of the latest technology and advancements in the field of human-derived ASC and SVF. The chapters in this book are organized into four parts. Part One focuses on human ASC’s isolation, characterization, and differentiation. Part Two describes the isolation and characterization of ASC and SVF from canine, feline, and murine tissues. Part Three looks at hydrogels, scaffolds, and microphysiological systems, and Part Four talks about the new assays and applications using ASC. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
