Advances in pharmacokinetics and pharmacodynamics
- المؤلف
- Panos Macheras
- سنة النشر
- 2023
- الناشر
- Springer
- لغة الملف
- انكليزي
- نوع الملف
- Book
- تصنيف الكتاب
- Medical Science
- تحميل الكتاب قراءة الكتاب
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
الكلمات المفتاحية: Pharmacology / Drug delivery / Drugs Physiological effect / Médicaments Effets physiologiques / Pharmacocinétique / Pharmacokinetics / Pharmacokinetics / Pharmacodynamics / PBPK models / Biopharmaceutics / Pbftpk models / Pk/pd modles / Reproducibility / Subject variability / Physiology / Variability
