Antimalarial natural products
- المؤلف
- A. Douglas Kinghorn
- سنة النشر
- 2022
- الناشر
- Springer
- لغة الملف
- انكليزي
- نوع الملف
- Book
- تصنيف الكتاب
- Medical Science
- تحميل الكتاب قراءة الكتاب
Begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type.
الكلمات المفتاحية: Malaria / Quinine / Artemisinin / Plasmodium falciparum / Mechanism of action / Alkaloids / Terpenoids / Organic chemistry / Biochemistry - General / Medicinal chemistry / Parasitology / Pharmaceutical sciences / Antimalarials / Natural products
