تحسين النتائح
ترتيب حسب
من
الى
الصفحة 1
الصفحة 1
La riabilitazione dei disturbi cognitivi nella sclerosi multipla = The rehabilitation of cognitive disorders in multiple sclerosis
Multiple sclerosis is one of the most frequent causes of chronic disability in young adults. It mainly affects individuals between 20 and 50 years of age, with a peak of incidence around the age of 30. This disease is characterized by the presence of demyelinating lesions of an inflammatory nature disseminated in the central nervous system. The different localization of these lesions is at the basis of the variability of clinical symptoms which can be characterized by motor, sensory, neurovegetative and cognitive disorders. The latter concern about half of the patients affected by this pathology and have a significant impact on the personal, family and work situation of these patients.
Cancer in the Arab World
Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab world who provide vital information on cancer statistics and risk factors, available clinical care pathways and infrastructure, and prevention programs in their individual countries. The chapters also address specific challenges in each country and insights into future directions to achieve optimal care with conventional and novel diagnostics and therapies to keep up with the era of precision medicine.
Atlas of Woody Plant Stems : Evolution, Structure, and Environmental Modifications
he „Atlas of Woody Plant Stems“ is a com- Naturally, it was impossible to cover completely the Tprehensively illustrated book with short, in- enormous variability of plant life forms. We have formative texts. We chose this layout because plant tried, however, to illustrate the main principles and anatomy and morphology can only be conveyed by features. Many decades of collection and prepa- detailed pictures. In addition, a vivid presentation tion provided the basis for this book.
Appropriate Dose Selection - How to Optimize Clinical Drug Development
Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers – based on the (known) pharmacology of the drug and/or biology of the underlying disease – along with exposure–response evaluation throughout all phases of drug development can quantitatively integrate clinical pharmacology knowledge, provide early proof of concept, and help in rational dose selection and rational drug product labeling for clinical use.
Advances in pharmacokinetics and pharmacodynamics
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Machine Learning for Multimedia Content Analysis
Challenges in complexity and variability of multimedia data have led to revolutions in machine learning techniques. Multimedia data, such as digital images, audio streams and motion video programs, exhibit richer structures than simple, isolated data items. A number of pixels in a digital image collectively conveys certain visual content to viewers. A TV video program consists of both audio and image streams that unfold the underlying story. To recognize the visual content of a digital image, or to understand the underlying story of a video program, we may need to label sets of pixels or groups of image and audio frames jointly.
Applied Civil Engineering Risk Analysis
Povides readers with the tools needed to determine the probability of failure, and when multiplied by the consequences of failure, illustrates how to assess the risk of civil engineering problems. Presenting methods for quantifying uncertainty that exists in engineering analysis and design, with an emphasis on fostering more accurate analysis and design.
Managing Weather and Climate Risks in Agriculture
In many parts of the world, weather and climate are one of the biggest production risks and uncertainty factors impacting on agricultural systems performance and management. Both structural and non-structural measures can be used to reduce the impacts of the variability (including extremes) of climate resources on crop production. While the structural measures include strategies such as irrigation, water harvesting, windbreaks etc., the non-structural measures include use of seasonal to interannual climate forecasts, improved application of medium-range weather forecasts and crop insurance. This book based on an International Workshop held in New Delhi, India should be of interest to all organizations and agencies interested in improved risk management in agriculture.
Climatic Change and its Impacts : An Overview Focusing on Switzerland
This book focuses upon climate processes, variability and change and applies the general principles related to these issues, particularly in Switzerland. Although a small country, Switzerland is characterized by complex topography where climatic processes are often enhanced due to the presence of the Alps. In addition, there is a remarkable density of observational data in both the natural and social sciences that enable a comprehensive assessment of climate processes, their long-term trends and their impacts. This book is intended for students from the undergraduate level onwards and researchers interested in climate issues specific to the alpine region.
Climate Variability, Predictability and Climate Risks : A European Perspective
This book provides an integrated assessment of issues related to climate variability and change, predictability and risks. It details both the technical aspects of variability and abrupt climate change and the agricultural and economical impacts and consequences.
Climate Variability and Extremes during the Past 100 Years
This volume provides an up to date overview of climate variability during the 20th century in the context of natural and anthropogenic variability. It compiles a number of contributions to a workshop held in Gwatt, Switzerland, in July 2006 dealing with different aspects of climate change, variability, and extremes during the past 100 years.
Climate prediction and agriculture : Advances and challenges
Improved adaptation of food production, particularly in areas where climate variability is large, holds the key to improving food security for human populations. Increasing climate knowledge and improved prediction capabilities facilitate the development of relevant climate information and prediction products for applications in agriculture to reduce the negative impacts due to climate variations and to enhance planning activities based on the developing capacity of climate science. This book, based on an International Workshop held in Geneva in 2005, reviews the advances made so far in seasonal climate predictions and their applications for management and decision-making in agriculture and identifies the challenges to be addressed in the next 5 to 10 years to further enhance operational applications of climate predictions in agriculture, especially in the developing countries.
Beam Instrumentation and Diagnostics
This treatise covers all aspects of the design and the daily operations of a beam diagnostic system for a large particle accelerator. A very interdisciplinary field, it involves contributions from physicists, electrical and mechanical engineers and computer experts alike so as to satisfy the ever-increasing demands for beam parameter variability for a vast range of operation modi and particles. The author draws upon 40 years of research and work, most of them spent as the head of the beam diagnostics group at GSI. He has illustrated the more theoretical aspects with many real-life examples that will provide beam instrumentation designers with ideas and tools for their work.
Atmospheric and Oceanic
This volume contains many original findings on mesoscale processes in atmospheric and oceanic systems through mathematical modeling, numerical simulations and field experiments. These scientific papers examine and provide the latest developments on a range of topics that include tropical cyclones/hurricanes, mesoscale variability and modeling, seasonal monsoons and land surface processes including atmospheric boundary layer. This volume will be useful as a reading material in graduate level courses dealing with mesoscale systems, weather, climate, monsoon variability and boundary layer.
Airglow as an Indicator of Upper Atmospheric Structure and Dynamics
The book summarizes international progress over the last few decades in upper atmosphere airglow research. Measurement methods, theoretical concepts and empirical models of a wide spectrum of upper atmospheric emissions and their variability are considered. The book contains a detailed bibliography of studies related to the upper atmosphere airglow.
Advances in Cardiac Signal Processing
Deals with the acquisition and extraction of the various morphological features of the electrocardiogram signals.In the first chapters the book first presents data fusion and different data mining techniques that have been used for the cardiac state diagnosis. The second part deals with heart rate variability (HRV), a non-invasive measurement of cardiovascular autonomic regulation. Next, visualization of ECG data is discussed, an important part of the display in life threatening state. Here, the handling of data is discussed which were acquired during several hours. In the following chapters the book discusses aortic pressure measurement which is of significant clinical importance. It presents non-invasive methods for analysis of the aortic pressure waveform, indicating how it can be employed to determine cardiac contractility, arterial compliance, and peripheral resistance. In addition, the book demonstrates methods to extract diagnostic parameters for assessing cardiac function. Further the measurement strategies for contractile effort of the left ventricle are presented. Finally, the book concludes about the future of cardiac signal processing leading to next generation research topics which directly impacts the cardiac health care.
