تحسين النتائح
ترتيب حسب
من
الى
الصفحة 1
الصفحة 1
Advances in pharmacokinetics and pharmacodynamics
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Bayesian Networks and Decision Graphs
Probabilistic graphical models and decision graphs are powerful modeling tools for reasoning and decision making under uncertainty. As modeling languages they allow a natural specification of problem domains with inherent uncertainty, and from a computational perspective they support efficient algorithms for automatic construction and query answering. This includes belief updating, finding the most probable explanation for the observed evidence, detecting conflicts in the evidence entered into the network, determining optimal strategies, analyzing for relevance, and performing sensitivity analysis. The book introduces probabilistic graphical models and decision graphs, including Bayesian networks and influence diagrams.It contians two parts. The first part focuses on probabilistic graphical models. Compared with the previous book, the new edition also includes a thorough description of recent extensions to the Bayesian network modeling language, advances in exact and approximate belief updating algorithms, and methods for learning both the structure and the parameters of a Bayesian network. The second part deals with decision graphs, and in addition to the frameworks described in the previous edition, it also introduces Markov decision processes and partially ordered decision problems.
Artificial intelligence and machine learning in health care and medical sciences : Best practices and pitfalls
Provides a detailed review of the latest methods and applications of artificial intelligence (AI) and machine learning (ML) in medicine. With chapters focusing on enabling the reader to develop a thorough understanding of the key concepts in these subject areas along with a range of methods and resulting models that can be utilized to solve healthcare problems, the use of causal and predictive models are comprehensively discussed. Care is taken to systematically describe the concepts to facilitate the reader in developing a thorough conceptual understanding of how different methods and resulting models function and how these relate to their applicability to various issues in health care and medical sciences. Guidance is also given on how to avoid pitfalls that can be encountered on a day-to-day basis and stratify potential clinical risks.
Advances in Assessment and Modeling of Earthquake Loss
Originates from an international workshop organized by Turkish Natural Catastrophe Insurance Pool (TCIP) in November 2019 that gathered renown researchers from academia, representatives of leading international reinsurance and modeling companies as well as government agencies responsible of insurance pricing in Turkey. The book includes chapters related to post-earthquake damage assessment, the state-of-art and novel earthquake loss modeling, their implementation and implication in insurance pricing at national, regional and global levels, and the role of earthquake insurance in building resilient societies and fire following earthquakes. The rich context encompassed in the book makes it a valuable tool not only for professionals and researchers dealing with earthquake loss modeling but also for practitioners in the insurance and reinsurance industry.
A Structural Framework for the Pricing of Corporate Securities : Economic and Empirical Issues
This book is the first comprehensive treatment, of structural credit risk models for the simultaneous and consistent pricing of corporate securities. Through the development of a flexible economic framework based on the firm's EBIT, the reader is taken from the economic principles of firm value models to the empirical implementation. Analytical solutions are provided, if EBIT follows an arithmetic or geometric Brownian motion.
Mathematical Epidemiology
Based on lecture notes of two summer schools with a mixed audience from mathematical sciences, epidemiology and public health, this volume offers a comprehensive introduction to basic ideas and techniques in modeling infectious diseases, for the comparison of strategies to plan for an anticipated epidemic or pandemic, and to deal with a disease outbreak in real time. It covers detailed case studies for diseases including pandemic influenza, West Nile virus, and childhood diseases. Models for other diseases including Severe Acute Respiratory Syndrome, fox rabies, and sexually transmitted infections are included as applications. Its chapters are coherent and complementary independent units. In order to accustom students to look at the current literature and to experience different perspectives, no attempt has been made to achieve united writing style or unified notation.
Lie Algebras and Applications
This book, designed for advanced graduate students and post-graduate researchers, provides an introduction to Lie algebras and some of their applications to the spectroscopy of molecules, atoms, nuclei and hadrons. In the first part, a concise exposition is given of the basic concepts of Lie algebras, their representations and their invariants. The second part contains a description of how Lie algebras are used in practice in the treatment of bosonic and fermionic systems. Physical applications considered include rotations and vibrations of molecules (vibron model), collective modes in nuclei (interacting boson model), the atomic shell model, the nuclear shell model, and the quark model of hadrons. One of the key concepts in the application of Lie algebraic methods in physics, that of spectrum generating algebras and their associated dynamic symmetries, is also discussed. The book contains many examples that help to elucidate the abstract algebraic definitions. It provides a summary of many formulas of practical interest, such as the eigenvalues of Casimir operators and the dimensions of the representations of all classical Lie algebras.
Advances in Mathematical Finance
This volume brings together a collection of chapters by some of the most distinguished researchers and practitioners in the fields of mathematical finance and financial engineering. Presenting state-of-the-art developments in theory and practice.
A rose armed with thorns : Spinoza’s Philosophy under a novel lens
presents a systemic analysis of Spinoza’s philosophy and challenges the traditional views. It deals with Spinoza’s concepts of substance, truth conditions, attributes, and the first, second, and supreme grades of knowledge. Based upon an analysis of the relevant details in all of Spinoza’s philosophical works, reveals many important points, including the following: Spinoza’s system is not, nor is meant to be, a foundational-deductive system but was meant to be a coherent system of a network model. Spinoza’s reality is not made in the image of a mathematical model. Imaginatio, the first grade of knowledge, and ratio, the second grade, are parts or properties of the supreme grade of knowledge, scientia intuitiva, which is their essence.
A life cycle for clusters? : The dynamics of agglomeration, change, and adaption
The phenomenon of non-random spatial concentrations of firms in one or few related sectors (clusters) is intensively debated in economic theory and policy. The euphoria about successful clusters however neglects that historically, many thriving clusters did deteriorate into old industrial areas. This book studies the determinants of cluster survival by analyzing their adaptability to change in the economic environment. Linking theoretic knowledge with empirical observations, a simulation model (based in the N/K method) is developed, which explains when and why the cluster's architecture assists or hampers adaptability. It is found that architectures with intermediate degrees of division of labour and more collective governance forms foster adaptability. Cluster development is thus path dependent as architectures having evolved over time impact on the likelihood of future survival.
