تحسين النتائح
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الصفحة 6
الصفحة 6
Anti-viral metabolites from medicinal plants
Covers general concepts of anti-viral metabolites, classifications, ethnopharmacology, chemistry, clinical and preclinical studies focusing on different medicinal plants against various types of viral infections. Various plants have been used in medicine since ancient times and are known for their strong therapeutic effects. The book will describe potential antiviral properties of medicinal plants against a diverse group of viruses, and provide an insight to the potential plants possess for broad-spectrum antiviral effects against emerging viral infections.The book aims to target a broad audience including virologists, molecular biologist, microbiologist and scientists working with natural products as well as researchers, students, healthcare experts involved in pharmaceutical and medical field.
Antisense RNA Design, Delivery, and Analysis
This volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Antioxidants effects in health : The bright and the dark side ; 1st ed.
Examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants’ historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.
Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis
Covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome).
Antimalarial medicinal plants
Malaria continues to affect a large population of the world, especially in third world countries. The spread of drug-resistant parasites demonstrates the need for antimalarial agents with various modes of action. The search for remedies derived from medicinal plants for the treatment of malaria is reliant on accurate ethnobotanical and ethnopharmacological information obtained from traditional medical practitioners. Antimalarial Medicinal Plants provides information on bioactive compounds and therapeutic potentials of several antimalarial plant species found around the globe. This book evaluates these plant species with respect to their biology, diversity, distribution, and pharmacological values.
Anticancer activity in heterocyclic organic structures : A pathway to novel drug development : Part 1
New Directions in Organic & Biological Chemistry, explores the development of cancer therapeutics, focusing on molecular chemistry and advanced drug design approaches. Written by experts in theoretical chemistry and molecular chemistry, they bridge the gap between theoretical chemistry, molecular biology, and drug development. In Part I, they focus on the fundamental properties of heterocyclic compounds and innovative methodologies being employed to enhance therapeutic potential. By exploring various classes of heterocyclic compounds and diverse anticancer mechanisms.
Antibiotics Simplified
Designed to bridge knowledge gained in basic sciences courses with clinical practice in infectious diseases. This practical text reviews basic microbiology and how to approach the pharmacotherapy of a patient with a presumed infection. It also contains concise Drug Class Reviews with an explanation of the characteristics of various classes of antibacterial drugs and antifungal drugs.
Androgen Excess Disorders in Women
The field of androgen excess disorders has advanced substantially since the original publication of this book. The Androgen Excess Society (AES) was founded to bring together investigators in the field. A better understanding of the screening, progression, and molecular genetics of nonclassic adrenal hyperplasia (NCAH) has improved the clinical care and diagnostic accuracy of these patients. New criteria for the diagnosis of the polycystic ovary syndrome (PCOS) were proposed in Rotterdam, criteria that have resulted in controversy and, hopefully, initiation of new studies. The association of insulin resistance with PCOS has been strengthened, and the role of metformin in tre- ing the infertility of the PCOS has been validated. Risks for diabetes and, more cont- versially, cardiovascular disease in women with PCOS have received substantial investigation. Our understanding of the epidemiology and economic impact of these disorders has expanded, emphasizing their critical importance.
Analyzing T cell responses : How to analyze cellular immune responses against tumor associated antigens
Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer
Analytical scientists in pharmaceutical product development : Task management and practical knowledge
Explains task management concepts and outlines practical knowledge to help pharmaceutical analytical scientists become productive and enhance their career. •Presents broad topics such as product development process, regulatory requirement, task and project management, innovation mindset, molecular recognition, separation science, degradation chemistry, and statistics. •Provokes thinking through figures, tables, and case studies to help understand how the various functions integrate and how analytical development can work efficiently and effectively by applying science and creativity in their work. •Discusses how to efficiently develop a fit-for-purpose HPLC method without screening dozens of columns, gradients, or mobile phase combinations each time, since the extra effort may not provide enough of a benefit to justify the cost and time in a fast-paced product development environment.
Analysing Ecological Data
This book provides a practical introduction to analysing ecological data using real data sets collected as part of postgraduate ecological studies or research projects. The first part of the book gives a largely non-mathematical introduction to data exploration, univariate methods (including GAM and mixed modelling techniques), multivariate analysis, time series analysis (e.g. common trends) and spatial statistics. The second part provides 17 case studies, mainly written together with biologists who attended courses given by the first authors. The case studies include topics ranging from terrestrial ecology to marine biology.
Analisi di Rasch e questionari di misura : Applicazioni in medicina e scienze sociali = Rasch analysis and measurement questionnaires: Applications in medicine and social sciences
Evaluation questionnaires are the most used tools nowadays in the field of medicine and the human sciences to evaluate variables such as disability, altruism or pain. However, clinicians are often unfamiliar with these tools. What do they really measure? How are the results to be interpreted? This book tries to answer these questions.
Analgesia
Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use.
Anafilassi in pediatria = Anaphylaxis in pediatrics
Anaphylaxis is defined as an immediate systemic reaction due to the rapid IgE mediated release of potent mediators from tissue mast cells and peripheral blood basophils and represents a generalized clinical condition that includes skin, respiratory, cardiovascular and gastrointestinal signs and symptoms. It includes various clinical pictures, which derive from the association of symptoms such as urticaria, angioedema, vomiting, diarrhea, asthma, dyspnoea, edema of the glottis, hypotension, shock, etc., not always easy to identify, which however require a timely and correct diagnostic approach. .
Alzheimers disease : Cellular and molecular aspects of Amyloid beta
This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy)
Alternative medicines for diabetes management : Advances in pharmacognosy and medicinal chemistry
Apart from diet and exercise, the strategic use of different classes of prescribed or non-prescribed xenobiotic compounds for the restoration of euglycemic levels in the body is well known. The ongoing rivalry between the recommended usage of allopathic medicines versus ayurvedic remedies has encouraged many researchers to focus their studies on thoroughly isolating and characterizing the extracts from different parts of plants and then evaluating their relative activities via in vitro, in vivo and in some cases clinical studies.
Algal Chemical Ecology
This is the first ever book devoted entirely to the chemical ecology of algae. Algae from both marine and freshwater habitats are covered, as are macroalgae (seaweeds) and microalgae (including phytoplankton). While its main emphasis is on the ecological rather than chemical aspects of the field, the book also includes a unique introductory chapter intended as a primer on algal natural products chemistry for ecologists. It elucidates the roles of chemical defenses in various regions and habitats, of DMSP, oxidative burst responses, and herbivore offense. Topics such as algal sensory chemical ecology and defenses against ultraviolet radiation are also treated, and an introduction to the chemical ecology of phytoplankton is provided.
AJCC Atlante per la stadiazione dei tumori maligni = Atlas for the Staging of Malignant Tumors
he atlas contains over 400 specially created black and white illustrations describing the anatomical extent of the malignant tumor in the primary site (T), regional lymph nodes (N) and distant metastases (M) for various sites, including the head and neck area, the digestive system, the thorax, the musculoskeletal system, the soft tissues, the breast, the urinary system and the genital system. Each illustration provides precise and detailed descriptions designed to clarify the crucial anatomical structures and to provide the reader with an immediate view of the progressive extension of the disease. The most important anatomical structures are identified by specific definitions.
Agricultural Biotechnology in China : Origins and Prospects
Building on a long tradition of agricultural advances, Chinese scientists have applied biotechnology techniques to develop hundreds of novel crop varieties suited to local farming conditions and challenges.Agricultural Biotechnology in China: Origins and Prospects is a comprehensive examination of how the origins of biotechnology research agendas, along with the effectiveness of the seed delivery system and biosafety oversight, help to explain current patterns of crop development and adoption in China. Based on firsthand insights from China’s laboratories and farms, Valerie Karplus and Dr. Xing Wang Deng explore the implications of China’s investment for the nation’s rural development, environmental footprint, as well as its global scientific and economic competitiveness.
Advances in pharmacokinetics and pharmacodynamics
Provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
