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Bioactives and pharmacology of Legumes
A variety of bioactives and therapeutics from the legume family (Fabaceae or Leguminosae) are thoroughly detailed. For each species included in the volume, a brief introduction is given, the plant’s bioactive compounds are listed, and its chemical structures shown, followed by their pharmacological activities. Many of these plants have medicinal activities that include antiviral, antimicrobial, antioxidant, anticancer, anti-inflammatory, and antidiabetic, hepatoprotective, nephroprotective and cardioprotective. The biochemical characteristics of the 37 plants included, such as the type of starch, protein, and fibers, can be exploited as binders, excipients, thickeners, and dispersants in the formulation of various products in the pharmaceutical industry. The published literature on the pharmacological activities on each species is reviewed and presented in a concise and clear manner.
Bioactive egg compounds
Hen eggs have exceptional potential as an inexhaustible source for a variety of products with unique properties. These products are valuable to human health and nutrition and can be used as raw materials for diverse purposes in the cosmetics and pharmaceutical industries. Bioactive Egg Compounds presents the latest results and concepts in the biotechnological use of egg compounds. Following an introduction to the different compounds of egg white, yolk and shell, the nutritive value of egg compounds is discussed. Procedures for processing egg compounds to improve their nutritive value are described, including the concept of so-called enriched eggs. Also described is the isolation and application of egg compounds with special properties, such as antibiotic action.
Bee products and their applications in the food and pharmaceutical industries ; 1st ed.
Focuses on the health benefits of selected bee products by looking more closely at their pharmacological potentials and therapeutic applications in coping with various diseases. The book explores some of these products, such as royal jelly, propolis and bee venom, which is highly attractive to the food supplement sector due to the biological actions that are proved by scientific studies. Bee products also attract the cosmetics industry by utilizing those products in various applications such as hair products, toothpaste, sunscreen creams, lip balsams, or facial moisturizing creams. Each chapter focuses on a particular health benefit, providing more compact and detailed information about each activity for a specific interest. The mainframe of the book is based on the medicinal and pharmacological functions of bee products, with the therapeutic applications for each bee product supporting the mechanism of action of their biological functions.
Basiswissen pharmakologie = Basic knowledge of pharmacology
Offers a clear and concise overview of all exam-relevant pharmacology content. It guides you through the entire foundational knowledge, from the basics to the most important clinical pictures, in an easily understandable way and aligned with the German National Competency-Based Learning Objectives for Medicine (GK) and National Competency-Based Learning Objectives for Medicine (NKLM). Benefit from the lecturer's many years of experience, who has carefully selected and presented the essential information for you.
Basic principles of drug discovery and development ; 2nd ed.
Presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields.
Bacterial signal transduction : Networks and drug targets
Interactions among different TCSs enable one system to respond to multiple signals, which is important for bacteria to minutely adjust themselves to complex environmental changes. Such interactions are found or predicted in various bacteria in this book. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been brought to light. Reports on these develop› ments have been put together in this book, Bacterial Signal Transduction: Networks andDrug Targets. This book Offers an incentive for graduate students, academic scientists, and researchers in the pharmaceutical industry to further elucidate the TCS networks and apply them in the search for novel drugs.
Asymmetric synthesis of drugs and natural products
Focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations
Arzneimittel, giftstoffe, kunststoffe, farbstoffe, pestizide = Pharmaceuticals, toxins, plastics, dyes, pesticides
Spells out which methods in which cases produce the most comprehensive results. Beschreibt alle modernen Spektroskopiemethoden in Theorie und Praxis. Behandelt die schnelle und effektive Identifikation von Giftstoffen. Enthält zahlreiche Absorptions- und Massenspektren aus der Zentralkartei der Bayer AG.
Applications of nanotechnology in drug discovery and delivery
Presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials
Application of microbes in environmental and microbial biotechnology
Discusses the innovative approaches and investigation strategies, as well as provides a broad spectrum of the cutting-edge research on the processing, properties and technological developments of microbial products and their applications. Microbes finds very important applications in our lives including industries and food processing. They are widely used in the fermentation of beverages, processing of dairy products, production of pharmaceuticals, chemicals, enzymes, proteins and biomaterials / conversion of biomass into fuel, fuel cell technology, health and environmental sectors. Some of these products are produced commercially, while others are potentially valuable in biotechnology. Microorganisms are considered invaluable in research as model organisms. This is a useful compilation for students and researchers in microbiology, biotechnology and chemical industries.
Anti-viral metabolites from medicinal plants
Covers general concepts of anti-viral metabolites, classifications, ethnopharmacology, chemistry, clinical and preclinical studies focusing on different medicinal plants against various types of viral infections. Various plants have been used in medicine since ancient times and are known for their strong therapeutic effects. The book will describe potential antiviral properties of medicinal plants against a diverse group of viruses, and provide an insight to the potential plants possess for broad-spectrum antiviral effects against emerging viral infections.The book aims to target a broad audience including virologists, molecular biologist, microbiologist and scientists working with natural products as well as researchers, students, healthcare experts involved in pharmaceutical and medical field.
Antioxidants effects in health : The bright and the dark side ; 1st ed.
Examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants’ historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.
Antimalarial natural products
Begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type.
Antibiotic Drug Resistance
This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases.
Animal Models of T Cell-Mediated Skin Diseases
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
Analytical scientists in pharmaceutical product development : Task management and practical knowledge
Explains task management concepts and outlines practical knowledge to help pharmaceutical analytical scientists become productive and enhance their career. •Presents broad topics such as product development process, regulatory requirement, task and project management, innovation mindset, molecular recognition, separation science, degradation chemistry, and statistics. •Provokes thinking through figures, tables, and case studies to help understand how the various functions integrate and how analytical development can work efficiently and effectively by applying science and creativity in their work. •Discusses how to efficiently develop a fit-for-purpose HPLC method without screening dozens of columns, gradients, or mobile phase combinations each time, since the extra effort may not provide enough of a benefit to justify the cost and time in a fast-paced product development environment.
An introduction to pharmacovigilance ; 2nd ed.
Designed to aid the rapid understanding of the key principles of pharmacovigilance. Packed full of examples illustrating drug safety issues it not only covers the processes involved, but the regulatory aspects and ethical and societal considerations of pharmacovigilance. Covering the basics step-by-step, this book is perfect for beginners and is essential reading for those new to drug safety departments and pharmaceutical medicine students. The second edition is thoroughly revised and updated throughout and includes a new chapter on clinical aspects of pharmacovigilance.
An introduction to medicinal chemistry
Providing an introduction to medicinal chemistry, this resource covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug
An introduction to bioanalysis of biopharmaceuticals
Provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness. Focuses on a broad range of conventional and emerging biopharmaceutical modalities including monoclonal antibody-based therapeutics, gene therapy, cell therapy, peptides and oligonucleotides.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
