الصفحة 20
الصفحة 20
Micrometastasis
Distant metastases are the main cause of cancer-related death. The onset of the metastatic process can now be assessed in cancer patients by the use of immunocytochemical and molecular methods that allow the identification of disseminated carcinoma cells in regional lymph nodes, peripheral blood or distant organs. There is increasing evidence that the detection and characterization of tumor cells present in bone marrow or peripheral blood can provide clinically important information. In this book, leading experts in the area of micrometastasis research provide an overview that summarizes the current state of research on micrometastatic disease in patients with solid tumors. In each chapter, the technical aspect as well as clinical relevance of micrometastasis detection is discussed. The book addresses basic researchers as well as clinicians involved in the treatment of cancer patients.
Micromachined Thin-Film Sensors for SOI-CMOS Co-Integration
Co-integration of sensors with their associated electronics on a single silicon chip may provide many significant benefits regarding performance, reliability, miniaturization and process simplicity without significantly increasing the total cost. Micromachined Thin-Film Sensors for SOI-CMOS Co-integration covers the challenges and interests and demonstrates the successful co-integration of gas-flow sensors on dielectric membrane, with their associated electronics, in CMOS-SOI technology.
Microbiomes and emerging applications
Covers a range of important topics and recent advances in metagenomics, microbiomes and their emerging applications, including microbiota transplantation and its health implications. It also discusses microbiome composition and development in humans. The contributors of this volume provide detailed information on prebiotics and probiotics for enhanced human health. They also introduce microbiomes as the next frontiers in medicine, agriculture, industry and environment. A chapter is presented that discusses probiotic research studies in Nigeria and Canada that led to the discovery of Lactobacillus pentosus KCA1. The book contains timely knowledge and will be useful reference material for scientists and researchers working in the fields of food and agricultural biotechnology, biopharmaceuticals and medical biotechnology, fermentation technology, environmental biotechnology, microbiomes and microbial biotechnology and health care.
Microbiology of Extreme Soils
This volume provides an excellent introduction to the study of extreme soil micro-biology, and a variety of the challenging and fascinating environments that Earth-bound microbes face. Some are natural, and some are the result of human activity, and all of them have lessons to teach us about life’s adaptations within the “extreme” hori-zons of terrestrial soils. What’s more, each of these chapters (including the chapter on the soils of Mars by Ronald L. Crawford and David A. Newcombe) can give us insights into strategies that may make life possible beyond the safe confines of our present-day biosphere, to other worlds in this solar system and beyond
Microbial Root Endophytes
Plant roots may not only be colonized by mycorrhizal fungi, but also by a myriad of bacterial and fungal root endophytes that are usually not considered by the investigators of classic symbioses. This is the first book dedicated to the interactions of non-mycorrhizal microbial endophytes with plant roots. The phenotypes of these interactions can be extremely plastic, depending on environmental factors, nutritional status, genetic disposition and developmental stages of the two partners. The book deals with diversity, life history strategies, interactions, applications in agriculture and forestry, methods for isolation, cultivation, and both conventional and molecular methods for identification and detection of these endophytes. The comprehensive reviews demonstrate the high diversity of interactions and will provoke further studies to better understand the mechanisms which determine whether a plant-microbial interaction remains asymptomatic, leads to disease or to a mutualistic interaction.
Microbial protein toxins
Since the initial establishment of Robert Koch’s postulates in the nineteenth century, microbial protein toxins have been recognized as a major factor of bacterial and fungal virulence. An increasing number of proteins produced and secreted by various bacteria, yeasts and plants are extremely toxic and most of them developed remarkably "intelligent" strategies to enter, to penetrate and to finally kill a eukaryotic target cell by modifying or blocking essential cellular components. This book describes the strategies employed by protein toxins to render their pro- and eukaryotic producers a selective growth advantage over competitors. In providing an up-to-date overview on the mode of protein toxin actions, it accommodates biomedically and biologically relevant toxin model systems. As a result, it significantly broadens our perspective on biochemical architecture and molecular ploy behind the lethal principles of pro- and eukaryotic toxins.
Microbial Phosphate Solubilization
Last decade has seen a significantly increased knowledge about phosphate solubilizing microorganisms. Sixty specialists from thirteen countries met in Salamanca to discuss the problems of the high P-unavailability as a soil nutrient for crops, and the hazards of an increasing phosphate input to aquatic habitats from industrial and mining activities, sewage disposal, detergents, and other sources. Updated solutions to enhance P-uptake by plants, bioremediation potential in the rehabilitation of ecosystems, taxonomic characterization interactions with mycorrizae, the physiological and molecular basis of PSM, and possibilities of genetic modifications of rhizospheric microorganisms were among the contributions presented. Challenges in commercializing a phosphate solubilizing microorganism were also outlined by a relevant biotech company.
Microbial Linear Plasmids
Microbial Linear Plasmids constitutes the first attempt to comprehensively assemble current knowledge of different types of such elements, highlight recent developments in the field, and challenge the distinction between viruses and linear plasmids.
Microbial Activity in the Rhizosphere
The rhizosphere is a very complex environment in which the effects of the plant on soil microorganisms and the effects of the microorganisms on the plant are interacting and are interdependent. Plant root exudates and breakdown products attract microbes and feed them and, in turn, the plants often benefit from the microbes. Interactions among microorganisms and plant roots are essential for nutritional requirements of the plant. Plant growth, development and productivity are largely dependent on the soil environment in the root region rhizosphere. The new techniques of studying the rhizosphere enables us to get a much better understanding of the dynamics of the rhizosphere population, such rhizosphere studies being of interest to agriculturists, soilbiologists, chemists, microbiologists and molecular biologists. The rhizosphere microbes in?uence the root environment in several ways. They may change the oxidation-reduction potential, influence the availability of moisture and nutrients, produce growth inhibiting or growth promoting substances in the form of exudates, provide competition and possibly induce many other effects. My corrhizal associations are beneficial in mineral uptake and in increasing root surface area for effective ion absorption. Antagonism, ompetition and synergism in soil and the rhizoplane (rhizosphere) are the most important microbial interactions to consider in the study of rhizosphere biology. With the growing information on the production of growth regulators, competitiveness of the microbes in the rhizosphere, microsymbionts, and other factors, their effect upon plant growth will become more evident. Experiments on the introduction of microbes or their products in the rhizosphere will help to improve our understandingofthebiologyoftherhizosphere.
Microbes in agri-forestry biotechnology
Explores recent advances on the use of microbes for agri-forestry biotechnological applications. It provides technical concepts and discussions on the use of microorganisms for processes such as bioprocessing, bioremediation, soil enhancement, aquaponics advances, and plant-host symbiosis. The book provides an overview of the microbial approach to the tools and processes used in agriculture and forestry that make or modify products, improve plants for specific uses, and make use of livestock in agricultural systems. The authors discuss the main process conditions that enhance agri-forestry applications with the use of microbes and introduce the use of genetically modified (GM) microbes in agrobiotechnology. Finally, the authors explore the main technological advances in the production of secondary metabolites with potential applications in agri-forestry.
Microarrays in Inflammation
The book is of interest to academic and industrial researchers but also clinicians who are working on inflammation related topics and would like to extend their knowledge about microarrays and the application thereof. After reading the book a researcher or clinician should be in the position to plan, perform and analyse or to critically review microarray experiments related to inflammation research.
Micro Cogeneration : Towards Decentralized Energy Systems
The need for replacement is an extremely important driving force for the current transformation, forcing conventional and new technologies to compete for a role in the future energy supply. The overall transformation of electricity systems is neither driven nor shaped by technical or societal modifications alone, but rather by a rich diversity of processes in the realms of technology, politics, society and economy.
Michael Van Valkenburgh Associates : Allegheny Riverfront Park
Part of the "Source Books in Landscape" series, this book focuses on Michael Van Valkenburgh's Allegheny Riverfront Park project for Pittsburgh, Pennsylvania. It provides documentation of this project, following its development from conception through completion using sketches, drawings, models, renderings, working drawings, and photographs.
Michael Graves : Images of a grand tour
Michael Graves: Images of A Grand Tour collects for the first time the stunning artwork produced during this trip. Delicate pencil sketches, striking ink washes, and colorful photographs show the deep connection Graves had to the places he visited, from the Roman Forum to the Grecian Acropolis to Wiltshires Stonehenge. They also tell something of the education of an architect, bringing to light the classical buildings that caused Graves to reexamine his early devotion to modernism. A foreword by Graves reflects on these travels from the distance of forty years
MICAI 2008 : Advances in Artificial Intelligence ;7th Mexican International Conference on Artificial Intelligence, Atizapán de Zaragoza, Mexico, October 27-31, 2008 Proceedings
The 96 revised full papers presented together with 2 invited lectures were carefully reviewed and selected from 363 submissions. The papers are organized in topical sections on logic and reasoning, knowledge-based systems, knowledge representation and acquisition, ontologies, natural language processing, machine learning, pattern recognition, data mining, neural networks, genetic algorithms, hybrid intelligent systems, computer vision and image processing, robotics, planning and scheduling, uncertainty and probabilistic reasoning, fuzzy logic, intelligent tutoring systems, multi-agent systems and distributed ai, intelligent organizations, bioinformatics and medical applications, as well as applications.
mHealth Innovation in Asia : Grassroots Challenges and Practical Interventions
Offers a detailed account of a range of mHealth initiatives across South, Southeast and East Asia. It provides readers with deep insights into the challenges such initiatives face on the ground, and a view of the diverse cultural contexts shaping strategies for overcoming these challenges. The book brings together various discussions on the broader mHealth literature, and demonstrates how a research focus on diverse Asian contexts influences the success and/or failure of current mHealth initiatives. It also highlights the important roles social scientists can play in advancing theoretical approaches, as well as planning, implementing and evaluating mHealth initiatives. The book is a valuable resource for project planners, policy developers in NGOs and government institutions, as well as academics, researchers and students in the fields of public health, communications and development studies.
Metric Handbook : Planning and Design Data
A major handbook of planning and design data for architects and architecture students. Covering basic design data for all the major building types, it is the ideal starting point for any project. For each building type, the book gives the basic design requirements and all the principal dimensional data, and succinct guidance on how to use the information and what regulations the designer needs to be aware of.
Metric Driven Design Verification : An Engineer's and Executive's Guide to First Pass Success
A metric based flow is described that focuses on the four steps of: 1. Planning: Defining what needs to be done and the automatically trackable metrics that will be used to measure progress. 2. Execution: Implementing verification environments and then extensively exercising the device under verification utilizing comprehensive, massively parallel regression strategies. 3. Measurement: Automatically capturing the metrics defined in planning to provide objective data with which to manage the verification project. Custom tailoring those metrics through an automated reporting framework to provide all stakeholders a real-time meaningful view of project status. 4. Response: Utilizing the returned metrics to effectively adapt to changing project conditions. Making use of automated response mechanisms to automate engineering processed and management response to streamline project management processes
Methods to study litter decomposition : A practical guide
Decomposition of organic matter is a major ecosystem process involving an array of different organisms, including bacteria, fungi and invertebrates. The main objective of this book is to provide students and laboratory instructors at universities and professional ecologists with a broad range of established methods to study plant litter decomposition. Detailed protocols for direct use in the field or laboratory are presented in an easy to follow step-by-step format. A short introduction to each protocol reviews the ecological significance and principles of the technique and points to key references. Although most methods are described for freshwater ecosystems, many will work equally well in the presented or slightly modified form for studies in marine and terrestrial environments.
Methods of Celestial Mechanics: Vol. I: Physical, Mathematical, and Numerical Principles
G. Beutler's Methods of Celestial Mechanics is a coherent textbook for students in physics, mathematics and engineering as well as an excellent reference for practitioners. This Volume I gives a thorough treatment of celestial mechanics and presents all the necessary mathematical details that a professional would need. After a brief review of the history of celestial mechanics, the equations of motion (Newtonian and relativistic versions) are developed for planetary systems (N-body-problem), for artificial Earth satellites, and for extended bodies (which includes the problem of Earth and lunar rotation). Perturbation theory is outlined in an elementary way from generally known mathematical principles without making use of the advanced tools of analytical mechanics. The variational equations associated with orbital motion - of fundamental importance for parameter estimation (e.g., orbit determination), numerical error propagation, and stability considerations - are introduced and their properties discussed in considerable detail. Numerical methods, especially for orbit determination and orbit improvement, are discussed in considerable depth. The algorithms may be easily applied to objects of the planetary system and to Earth satellites and space debris.
