الصفحة 10
الصفحة 10
Breast cancer genetics, immunology, and immunotherapy : An interdisciplinary approach
Publishes comprehensive volumes on immune and genetic mechanisms of breast cancer diagnosis and prognosis. The role of molecular genetics, interleukins, chemokine receptor, and tumor-infiltrated lymphocytes-TILS in breast cancer are explained. Targeting myeloid determinants, SiRNA loaded in drug delivery nanosystems, nucleic acid and drug dual agent nanoplatforms, and oncolytic virotherapy are also discussed in the treatment of breast cancer, particularly in multidrug resistant and metastatic breast cancer.
Brain tumor pathology : Current diagnostic hotspots and pitfalls
Since Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.
Biotechnologies for plant mutation breeding : Protocols
This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.
Biosensing for the 21st Century
Covers trends in modern biotechnology All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated
Biopharmaceutical drug design and development
Biopharmaceutical Drug Design and Development, Second Edition, updates the widely successful first edition, published in 1999. This new, expanded edition investigates the dozens of new biopharmaceutical drugs that have become available since the publication of the first edition. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, such as bioinformatics, DNA microarrays, transgenics, therapeutic gene delivery, stem cells, nucleic acid-based therapeutics, and macromolecular drug delivery. Authors also study pharmacogenetics in the clinic and changes in biologic drug approval at the FDA. Biopharmaceutical Drug Design and Development, Second Edition, is a worthy sequel in the discussion on the dynamic, exciting field of biotechnology.
Biology of orthodontic tooth movement : current concepts and applications in orthodontic practice
Presents the current knowledge and understanding of the biological processes involved in the orthodontic movement of teeth and discusses recent progress in the field. It links research advances to their immediate clinical applications and offers researchers and clinicians a state of the art reference on topical issues relating to orthodontic tooth movement.
Biology of Inositols and Phosphoinositides
This volume describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in the area since the publication of volume 26 in 1996 in this series. The progress made in dissecting the genetics, structure and evolution of the seminal enzyme for synthesis of inositol in the biological system has driven the understanding of the enzyme forward. With the current genomic and proteomic tools in place the new role of inositols, inositol phosphates and phosphoinositides in cell signaling or stress response has been explored. These advances are described.
Biology and Ecology of Norway Spruce
This book presents a concise and comprehensive review of the biology, ecology, and management of Norway spruce. It integrates classic and contemporary literature (more than 2000 works cited in the text), highlighting basic research and forestry practices in central and eastern Europe. The topics include anatomy and morphology, physiology and nutrition, reproductive biology and genetics, and ecology. In addition, it examines mycorrhiza, diseases and pests as well as silviculture and wood products. In the light of increasing threats to forest health from air pollution, climate change, and insects and disease, it provides an essential information source to those concerned with the ecology, conservation, and management of the species
Biological nitrogen fixation, sustainable agriculture and the environment ; Proceedings of the 14th International nitrogen fixation congress
Covers aspects of fundamental and applied nitrogen-fixation research, from biochemistry and chemistry through genetics, regulation and physiology to agricultural practice and environmental impact. This work describes progress on studies of potential catalysts for nitrogen fixation; how the N2-fixing process is regulated in living cells; and more.
Biological nitrogen fixation : Towards poverty alleviation through sustainable agriculture ; Proceedings of the 15th International nitrogen fixation congress and the 12th International Conference of the African Association for Biological Nitrogen Fixation
This volume covers recent developments in both fundamental and applied research in biological nitrogen fixation. It emphasizes the application of biological nitrogen fixation for sustainable agriculture, which should lead to poverty alleviation, environmental protection, and good agricultural practices generally. The roles of, and advances in, plant breeding, plant molecular biology, nodule physiology, and symbiotic and associative interactions between plants and microbes in sustaining agricultural productivity and soil fertility are described. The evolution of symbioses and nitrogen fixation are also covered in this volume. To ensure high agricultural productivity, while protecting the environment (both soil and water resources), requires plant cultivars that also respond to beneficial microbes.
Bioinformatics research and development ; 2nd International Conference, BIRD 2008 Vienna, Austria, July 7-9, 2008 Proceedings
This book constitutes the refereed proceedings of the Second International Bioinformatics Research and Development Conference, BIRD 2008, held in Vienna, Austria in July 2008.
Bioinformatics research and applications ; 3rd International Symposium,ISBRA 2007, Atlanta, GA, USA, May 7-10, 2007, Proceedings
This book including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.
Bioinformatics of genome regulation and structure II
The conference was organized by the Laboratory of Theoretical Genetics, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. The material covers the most recent topics in bioinformatics, including (i) regulatory genomic sequences: databases, knowledge bases, computer analysis, modeling, and recognition; (ii) large-scale genome analysis and functional annotation; (iii) gene structure detection and prediction; (iv) comparative and evolutionary genomics; (v) computer analysis of genome polymorphism and evolution; computer analysis and modeling of transcription, splicing, and translation; structural computational biology: structure- function organization of genomic DNA, RNA, and proteins; (vi) gene networks, signal transduction pathways, and genetically controlled metabolic pathways: databases, knowledge bases, computer analysis, and modeling; principles of organization, operation, and evolution; (vii) data warehousing, knowledge discovery and data mining; and (viii) analysis of basic patterns of genome operation, organization, and evolution.
Bioinformatics and the cell : Modern computational approaches in genomics, proteomics and transcriptomics
"Xuhua Xia’s Bioinformatics and the Cell is a welcome addition to the bourgeoning field of bioinformatics text books. Xia stakes out a too-often neglected middle ground in bioinformatics by presenting a work that emphasizes methods’ biological utility without eschewing algorithmic formalism. Readers will find a well-rounded presentation of bioinformatics techniques employed in genomics, transcriptomics and proteomics – unified throughout by the common theme of molecular evolution."
Bioinformatics
In this textbook present mathematical models in bioinformatics and they describe the biological problems that inspire the computer science tools used to handle the enormous data sets involved. The first part of the book covers the mathematical and computational methods, while the practical applications are presented in the second part. The mathematical presentation is descriptive and avoids unnecessary formalism, and yet remains clear and precise. Emphasis is laid on motivation through biological problems and cross applications. Each of the four chapters in the first part is accompanied by exercises and problems to support an understanding of the techniques presented. Each of the six chapters of the second part is devoted to some specific application domain: sequence alignment, molecular phylogenetics and coalescence theory, genomics, proteomics, RNA, and DNA microarrays. Each chapter concludes with a problems and projects section, to deepen the reader's understanding and to allow for the design of derived methods. Many of the projects involve publicly available software and/or Web-based bioinformatics depositories. Finally, the book closes with a thorough bibliography, reaching from classic research results to very recent findings, providing many pointers for future research.Overall, this volume is ideally suited for a senior undergraduate or graduate course on bioinformatics, with a strong focus on its mathematical and computer science background.
Bioethics and the Holocaust : A Comprehensive Study in How the Holocaust Continues to Shape the Ethics of Health, Medicine and Human Rights
This book offers a framework for understanding how the Holocaust has shaped and continues to shape medical ethics, health policy, and questions related to human rights around the world. The field of bioethics continues to face questions of social and medical controversy that have their roots in the lessons of the Holocaust, such as debates over beginning-of-life and medical genetics, end-of-life matters such as medical aid in dying, the development of ethical codes and regulations to guide human subject research, and human rights abuses in vulnerable populations. As the only example of medically sanctioned genocide in history, and one that used medicine and science to fundamentally undermine human dignity and the moral foundation of society, the Holocaust provides an invaluable framework for exploring current issues in bioethics and society today. This book, therefore, is of great value to all current and future ethicists, medical practitioners and policymakers – as well as laypeople.
Behavioral pharmacology of the cholinergic system
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Basis and Treatment of Cardiac Arrhythmias
Incorporating the information related to mechanisms and treatment of cardiac arrhythmia, this book discusses genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These approaches and implementations of anti-arrhythmic therapy derive from many decades of research.
Bacterial Genomes and Infectious Diseases
This book imparts fundamental knowledge on the structure, organization, and evolution of bacterial genomes. The value and power of comparative genomics and proteomics, bioinformatics, microarrays, and knockout animal models in analyzing genomes, bacteria-host interactions and disease are demonstrated. Also discussed are the genomes of virulent and nonvirulent strains and species, origin and evolution of pathogens, different models of bacteria-host interactions, and diseases mechanisms.
Bacterial and Bacteriophage Genetics
Genetic investigations and manipulations of bacteria and bacteriophage have made vital contributions to our basic understanding of living cells and to the development of molecular biology and biotechnology. This volume is a survey of the genetics of bacteria and their viruses, and it provides students with a comprehensive introduction to this rapidly changing subject. The book is written for upper level undergraduates and beginning graduate students, particularly those who have had an introductory genetics course.
