الصفحة 1
الصفحة 1
Z-DNA : Methods and protocols
Compiles key methods and techniques used to establish some of the structural and functional aspects of Z-form nucleic acids. Beginning with chapters on characterizing Z-DNA, the book continues by exploring structure determination techniques, gene- and genome-targeting methods and genome-wide approaches, Z-RNA study, and much more.
Your Skin is Your Mirror
Skin is a significant part of a body involve protect yourself from foreign body and harmful substance also maintains the physiological function like body temperature and preserve skin moisture. However, some factor, progressive the aging involves internal and external factor and their interactions, affecting a human individual from conception to death as well as the response of the human body to these factors that lead to decreases, the skin function, Appearance of wrinkles, sagging and hyperpigmentation make biological and clinical signs of skin aging. Now the medical science and technology is change and develop using therapy technique and cosmetic product like Botox, fillers, collagen, Hyaluronicacid and Mesotherapy improve skin tone and reduce aging signs and symptoms.
Viral Therapy
Virotherapy is a treatment using biotechnology to convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses, viral vectors for gene therapy and viral immunotherapy. These branches utilize three different types of treatment methods: gene overexpression, gene knockout, and suicide gene delivery. Gene overexpression adds genetic sequences that compensate for low to zero levels of needed gene expression. Gene knockout utilizes RNA methods to silence or reduce expression of disease-causing genes. Suicide gene delivery introduces genetic sequences that induce an apoptotic response in cells, usually to kill cancerous growths. In a slightly different context, virotherapy can also refer more broadly to the use of viruses to treat certain medical conditions by killing pathogens like Bacteriophages that specialized to kill Bacteria without harming human cell.
Vaccines, medicines and COVID-19 : How can WHO be given a stronger voice?
The considerable health, economic and social challenges that the world faced at the beginning of 2020 with COVID-19 continued and worsened in many parts of the world in the second-half of 2020 and into 2021. Many of these countries and nations wanted to explore COVID-19 on their own, sometimes without listening to the main international health bodies such as WHO, an agency of the United Nations system with long-standing experience and vast knowledge at the global level and of which all countries in the world are members.
U.S. Pharmacopeia National Formulary 2018 USP 41 NF 36
Contains standards for medicines, dosage forms, drug substances, excipients, biologics, compounded preparations, medical devices, dietary supplements, and other therapeutics. Offers convenient, comprehensive information for all phases of producing quality prescription, nonprescription, and compounded medicines; excipients; biologics; medical devices; and dietary supplements. It is essential for quality control, quality assurance, regulatory/compendial affairs, research and development, method development/analytical services, and corporate management. USP–NF monographs and methods can help to: Ensure compliance with required U.S. quality standards / Work to world-recognized standards of precision and accuracy / Validate test results against proven benchmarks / Establish and validate in-house standard operating procedures, and specifications / Expedite new product development and approvals
Turmeric and curcumin for neurodegenerative diseases
Examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference.
Treatment planning steps in oral implantology : a color atlas
Comprehensive guide to oral implantology for dental surgeons covering latest surgical advances and technologies, procedures for achieving optimal aesthetic results, managing bone deficiency in the posterior maxilla and mandible, and much more. Authored by internationally recognised experts in the field and features nearly 2500 images and illustrations. Covers : Internationally recognised author team Features nearly 2500 images and illustrations
Toll-Like Receptors (TLRs) and Innate Immunity
Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Thérapeutiques antiangiogéniques en cancérologie = Antiangiogenic therapeutics in oncology
The fundamental role of angiogenesis in tumor growth and spread has been known for over 30 years now. We have recently had effective anti-angiogenic drugs on many tumors. Their use requires a good knowledge of their mode of action, their side effects, their indications and their place in the therapeutic strategy. This work is therefore divided into three points: - It is first recalled the important role of tumor angiogenesis, the means available to evaluate it on histological samples, its practical modalities of use and the side effects of anti-cancer drugs. -angiogenic.- Then the therapeutic results obtained with the anti-VEGF antibodies and the anti-VEGFR tyrosine kinase inhibitors are detailed for each of the tumors.- Finally, the positioning of these new molecules in the multidisciplinary strategy is discussed. - view of other processing methods.
Therapeutic approaches in cancer treatment
A unique blend of structured information covering a broad area relevant to cancer therapeutics.This book comprises fourteen chapters covering cancer genomic approaches for cancer treatment, traditional modalities, chemotherapy, radiotherapy, hormonal therapy, immunotherapy, oncolytic virotherapy, which is another emerging field. Furthermore, it also covers targeted therapies in personalized medicine, which is again an emerging yet promising field for cancer treatment. Use of nanocarriers in the cancer treatment is another important aspect which is a developing thrive. This book is also unique about in covering psychological elements in cancer treatments and providing knowledge for nutritional assessments in cancer treatment. The book has very good text highlighting the important features with a blend of traditional and emerging treatment modalities. Furthermore, chemoresistance development and challenges it poses in cancer treatment along with the pharmacogenetics of anticancer drug, which is way important for the clinicians to understand for their individual patients, associated toxicities, and clinical responses to a particular drug.
Therapeutic Antibodies
Antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions and are becoming the molecules of choice for further combination therapies and cell engineering. Current developments and clinical successes are summarised by experts in the drug development field. A must read for immunologists, clinical scientists and novel drug developers.
The silent epidemic
Biofilm is a complex structure of microbiome having bacterial colonies adhere to the surface. These cells are embedded in extracellular polymeric substances, a matrix generally composed of eDNA, proteins and polysaccharides, showing high resistance to antibiotics. Quorum sensing plays an important role in regulating the biofilm formation. Biofilm is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. There are many approaches being used to control biofilm. Indeed, the adhesive characteristics of natural human flora are now considered as a tool for preventing the adhesion of pathogenic bacteria to avert infection. These antibiofilm approaches represent a promising therapeutic target in the treatment of biofilm infections and development of a strong capability to interfere with different phases of the biofilm development.
The Serotonin Receptors : From Molecular Pharmacology to Human Therapeutics
The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice.
The role of nanotechnology in protection
Nanotechnology is a new science and the revolution of the twenty-first century. There is a serious promising applications for nanotechnology that we can use in many fields, Such as (cosmetics, textiles, healthcare, tissue engineering, catalysis, functional coatings, medical diagnosis and therapeutics, sensors , communication engineering and water and air pollution treatment). It plays an essential role in protection by using it in sterilization and giving distinct results , it was also used to eliminate bacteria and viruses by incorporating nanofilter with many material containing the ability to reduce reproduction of bacteria or eliminating it. We have several examples of these materials like ( Copper (II) oxide, silver , graphene ) . Because of these unique features , nanofiber has been used in many filters types like ( air nanofilter , water nanofilter , oil nano filter ....etc.) But the specific type that interests us uses nanofilter in face masks.
The era of gene therapy
Typically, therapeutic gene therapies involve the transfer of genetic material into cells to reverse an abnormal condition or induce a new trait. Depending on the underlying genetic problem, various strategies such as addition, edition (repair), and deletion/knockout (inactivation) could be used. Sometimes gene therapy is used to add a normal and functional copy of an allele to increase gene expression, such as adding a normal human clotting factor IX allele to produce enough factor IX in hemophilia type B. Also, gene transferred by vectors...
The development in cancer therapy and early detection tools
Despite the development in cancer treatment there is still a high rate of mortality worldwide. Although the traditional ways of cancer treatments are still used as a first line therapy, however, new treatments have been developed which showed a high effect on cancer cells. Therefore, the aim of our study is to search for the most recent cancer therapies, such as anti-angiogenesis treatment and immune therapy and related early detection tools. We will focus on the most “resilient” aggressive types of cancers which people have a lack of information about, in order to let them be aware about their risk factors and how to avoid them, and to provide them with their symptoms as well.
The Dentist's Quick Guide to Medical Conditions
With increasing numbers of dental patients being elderly or having medical conditions, it is important for the dentist to understand how these conditions may impact dental treatment. The Dentist’s Quick Guide to Medical Conditions presents the relevant information dentists need—symptoms, diagnostic tests, medications prescribed, and dental management for each disease and condition.
The Crazy Paving
Pulmonary alveolar proteinosis (PAP) is a rare respiratory syndrome characterized by the accumulation of surfactant lipoproteins within the alveoli. Primary PAP is led by a granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling disruption. Secondary PAP is associated with various diseases causing a reduction in function and/or the number of alveolar macrophages. Congenital PAP emerges as a consequence of corrupted surfactant production, due to mutations affecting surfactant transporter or lung development.
The Chemokine Receptors
To date, there are over twenty different chemokine receptors, binding nearly fifty unique ligands that have been identified. In Chemokine Receptors, leading investigators attempt to distill the large body of literature ranging from basic molecular and cellular mechanism of chemokine receptors, to physiological and pathological roles of chemokines. Chemokines exhibit a tremendous functional diversity and participate in a wide variety of processes that include inflammation, innate and adaptive immunity, immune cell differentiation, angiogenesis, tumorigenesis, development, neurobiology and viral pathogenesis. Chemokine Receptors targets the pharmaceutical industry, provides an authoritative perspective on the future direction of this field, and insights into areas of active development of novel therapeutics.
Textbook of Personalized Medicine
This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considersgenetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various playersin it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed.
