تحسين النتائح
ترتيب حسب
من
الى
الصفحة 1
الصفحة 1
Managing Failed Anti-Reflux Therapy
This multiauthored text provides information on the pathophysiology of GERD, appropriate medical management, and proper indications for and performance of surgical and endoscopic procedures for GERD. Thousands of patients will experience inadequate relief from medical therapy or will develop complications from their procedures or recurrent or new symptoms afterwards; this text describes in detail the proper evaluation and management of such patients.
Management of Heart Failure ; Vol.2 : Surgical
Management of Heart Failure has been conceived as a rapid but comprehensive review for practitioners of all persuasions involved in the management of patients with heart failure. Heart failure is a problem of epidemic proportions in all parts of the world. State of the art treatment may not be accessible to all, but simply creating an awareness of simple methods of diagnosis and treatment would assist in promoting a better global response to this epidemic. This practical volume, written by a panel of world-renown cardiology experts, focuses on the surgical management of heart failure. Surgery for heart failure is an evolving and new area in cardiac surgery with many exciting developments.
Malattie dellapparato respiratorio = Respiratory system diseases
This book reports the status of the art of the community more diseases of the respiratory apparatus. The first part is dedicated to the anatomy of the lung, to the regulation of the respiration and to the respiratory mechanics, follows the functionalities of the respiratory pain and the invasive and non-invasive diagnosis, including the diagnosis per imaging in pneumology. Nella description of the particular malattie importance of this date in the chiarire the "perché" of the diversi symptoms and according to the clinical practice within the therapeutic approach, confronted with te international guideline, with the communication of the vast experience of the clinic of the author. The main objective of this book is that the recent acquisition of the physiology, pathophysiology and clinic of the respiratory system, including non-invasive mechanical ventilation, oxygen therapy and respiratory rehabilitation, and combining a clear description from the respiratory pathophysiology with emphasis on its clinical application. The volume is aimed both at students of the specialist degree course in medicine and surgery, and at specialists in diseases of the respiratory system. It also represents a valid reference for the general medicine doctor, above all when the last intention will increase the proprietary knowledge of clinics, diagnosis and therapy in the sector of the respiratory pathology, branch that always is often shared by the doctor and the specialist in the risoluzione of almost anche molto complessi.
Malattia coronarica : Fisiopatologia e diagnostica non invasiva con TC = Coronary heart disease: Pathophysiology and non-invasive diagnostics with CT
The work stems from the desire to provide the cardiologist or non-imaging physician with the basis for understanding technical principles and methods of acquiring and reconstructing images. At the same time, even the radiologist who does not have specific experience in cardiac imaging will be able to acquire basic knowledge of coronary anatomy and pathophysiology.
Lung biology and pathophysiology
The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.
Les douleurs abdominales en questions : Rôle physiopathologique de la sensibilité viscérale = Abdominal pain in question : The pathophysiological role of visceral sensitivity
The gut-brain axis refers to the network of nerve pathways that connect the myenteric plexus, the veritable "gut brain," to the central nervous system. Nearly 80% of these neurons are sensory neurons, and the afferent pathways that transmit information from the digestive tract to the central nervous system play a crucial role in the physiological regulation of digestive functions, as well as in certain pathological conditions. A large majority of these sensations remain unconscious and give rise to reflex responses. Only those requiring a conscious response reach the level of awareness in a normal state (hunger, thirst, the urge to defecate). In pathological situations, the same is true for painful sensations of digestive origin. Functional bowel disorders are a frequent reason for consultation. Their pathophysiology is now based on a model integrating the various etiological factors around the brain-gut axis. These patients frequently present with visceral hypersensitivity, which manifests as an increased perception of digestive sensations, notably the onset of pain in response to stimuli that are not painful in normal subjects. Recognizing the role of visceral hypersensitivity has made it possible to explain the mechanism of action of medications used to treat functional bowel disorders and paves the way for the development of new molecules acting on digestive afferents. In this book, we will describe the anatomical and physiological basis for understanding the concept of visceral sensitivity and the role of digestive afferents in the pathophysiology of acute and chronic abdominal pain, particularly irritable bowel syndrome.
Leptomeningeal Metastases
Leptomeningeal Metastases provides the reader with an overview of the state-of-the-art therapy for the leptomeningeal patient with additional information on epidemiology, symptom management, new clinical trials, and current basic research in animal models for experimental therapies. "Leptomeningeal metastases remains a devastating manifestation of hematologic malignancies and solid tumors. Leading figures in the field review the pathophysiology and clinical consequences of this process. State-of-the-art treatment strategies are presented highlighting advances in current management."
Clinical and Basic Immunodermatology
Clinical and Basic Immunodermatology is a comprehensive, yet readable and easily digested disease-focused textbook designed for Residents and Fellows in dermatology and immunology.
Chemokine biology : Basic research and clinical application ; Vol.2 : Pathophysiology of chemokines
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Chemokine biology : Basic research and clinical application ; Vol.1 : Immunobiology of chemokines
The discovery of interleukin-8 close to 20 years ago initiated a new field of research touching on many aspects of immunology and inflammation. Interleukin-8 is just one member of a large class of structurally related chemoattractant proteins, known as chemokines. Chemokines are involved in the traffic control of leukocytes, which bear the corresponding chemokine receptors on their surfaces. Today, it is clear that chemokines affect all aspects of immunology and even many unrelated fields, such as tissue development and tumor cell metastasis. Their fundamental contributions to chronic inflammatory diseases make them a principal target for the development of novel, anti-inflammatory therapeutics.
Cell volume and signaling
In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field.
Carpal Tunnel Syndrome
This book is an instrument for deepening their knowledge of this condition and its management. It can be considered a moment for reflection on a condition that is erroneously considered simple to treat and easy to resolve. The surgical chapters compare various complications as well as various conservative and rehabilitative treatment options, thus underlining that this condition must not be underestimated. Incorrect treatment can have many negative ramifications: not only that the patient is dissatisfied but it can also lead to the hand’s functional loss and render the patient an invalid.
Cardiac Mechanotransduction
For about hundred years the investigation of heart physiology has had one central guiding principle, the "law" of Frank and Starling. This connects the return of blood into the heart and the blood pressure with cardiac con traction force. The "law" does it in a way that enables the cardiovascular system to react to perturbations without major malfunctions. This book is a compilation of reviews of prominent scientists on this subject. The differ ence of the original formulation of the Frank-Starling principle is that mechanotransduction is the central theme that leads the reader through the book. Since the discovery of the "law" the scope of topics related to this subject has broadened enormously, as can be seen easily by glancing at the contents of this book. Mechanotransduction in the heart has many faces that range from molecules to humans and their diseases.
Cardiac drug therapy
Cardiac Drug Therapy, 7th ed., addresses the pharmacology and therapeutic application of drugs used to treat heart diseases and hypertension. Additions and updates to the sixth edition include six new chapters on current controversies in cardiac drug therapy such as the beta blocker issue many cardiologists are presently grappling with. The book provides practical advice on how to manage cardiac diseases and addresses the choice of one particular cardiac agent vs. another. In addition to providing core knowledge in cardiovascular therapeutics, the text assists in resolving some of the issues surrounding cardiac drugs. Cardiac Drug Therapy provides practical information including properties, dosage, side effects, potential salutary benefits, and drawbacks on virtually all commercially available cardiac drugs.
Calcium Signalling and Disease : Molecular Pathology of Calcium
This topic is a new entry in the area of cellular calcium signaling: yet, it now spans the entire area, with discoveries that cover both genetic and acquired pathologies, even offering glimpses in the direction of therapy.Cellular calcium homeostasis, and thus calcium signalling, is mainly regulated by membrane intrinsic proteins and calcium sensor proteins. Both classes may be involved in pathological processes that affect both human and animals, ranging from common and important diseases (e.g. migraine, diabetes, epilepsia, manic depression, infertility, various types of cancer, Alzheimer’s disease, muscular dystrophy) to rare genetic conditions (e.g., a number of genetic heart conditions, autoimmune retinopathies, night blindness, hereditary amyloid polyneuropathy, malignant hyperthermia, cerebellar ataxia, atherothrombotic disease).
Cachexia and Wasting : A Modern Approach
Aim of the volume is to provide the best available evidence on the pathogenesis, clinical features and therapeutic approach of cachexia, and to facilitate the understanding of the complex yet unequivocal clinical role of this syndrome, that truly represents a disease, or, better still, a disease within other different diseases.
Brain Metastases
Brain metastases are the most dreaded complication of systemic cancer, affecting approximately 170,000 people a year, a far greater incidence than primary brain tumors. Advances in modern chemotherapy have led to an improved control of system cancers, often with agents that poorly penetrate the central nervous system, resulting in an increasing incidence of brain metastases. Traditional chemotherapy has had little impact on brain metastases. The main therapeutic option is radiation therapy, and in a small number of patients - surgery. However, refinements in all of these treatments offer some positive outcomes and an increased ability to stratify patients based on certain criteria.
Bone Resorption
Bone Resorption, the second volume in the series Topics in Bone Biology, deals with the osteoclast, the bone-resorbing cell, its origins, its enzymes, the regulation of osteoclast activity, and structural aspects of bone resorption. Diseases involving osteoclast function are discussed from the genetic viewpoint in two chapters that span transgenic mouse models to human pathology. Another chapter treats diseases of osteoclast function. Because osteoporosis may be considered a disease in which the bone resorption rate exceeds formation, a separate chapter deals with current and potential therapeutic approaches to this widespread disease that affects both men and women. Bone metastases and an analysis of the central role of the osteoclast in this condition are treated in the concluding chapter.
Bone and Osteoarthritis
Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease.
Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics
In this newly updated second edition of Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics, William B. White, MD, and a panel of highly distinguished clinicians give a critical review of every aspect of the evaluation of high blood pressure. This includes home and ambulatory blood pressure monitoring, the relationship between whole-day blood pressure and the cardiovascular disease process, and the effects of antihypertensive therapies on these blood pressure parameters. World-class contributors describe the significant advances in our understanding of the circadian pathophysiology of cardiovascular disorders and demonstrate that ambulatory blood pressure values are independent predictors of cardiovascular morbidity and mortality.
