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Management of Complications in Refractive Surgery
This guide offers the reader practical pearls to the solution and prevention of the different complications of corneal and refractive surgery. All complications are described and lavishly illustrated from its pathogenesis to its treatment modalities.
Management of atopic dermatitis : Methods and challenges
This new edition builds upon the foundational knowledge covered in the first edition, covering the epidemiology, pathogenesis, and clinical presentation of atopic dermatitis in both pediatric and adult patients. It provides an overview of the mechanism and presentation of atopic dermatitis and focuses on the management methods experienced dermatologists have used to successfully manage atopic dermatitis. The book includes new chapters describing the special considerations for atopic dermatitis in skin of color patients, dedicated chapters on topical and oral prescription management reflected the latest FDA-approved treatments, and also a chapter covering the updated guidelines from the American Academy of Dermatology. A final chapter includes updates on the future of atopic dermatitis treatment.
Malignant Mesothelioma : Pathogenesis, Diagnosis, and Translational Therapies
(Review from JAMA) Malignant mesothelioma is an uncommon neoplasm usually associated with exposure to asbestos. Because of its low incidence, thorough reviews of the topic are hard to find. Harvey Pass and colleagues have edited an up-to-date, comprehensive book that includes a wide range of information, from a historical perspective to descriptions of the latest treatment. The authors . . . have written chapters on the carcinogenesis, molecular genetics, and clinical aspects of mesothelioma. Malignant Mesothelioma is suitable for a broad audience. Laboratory researchers will use it as a resource for information about the pathogenesis, animal models, molecular genetics, and cell lines of mesothelioma. . . . Clinicians will benefit from this complete guide to the presentation, prognosis, imaging, and treatment of the disease. I highly recommend this book to all who are interested in mesothelioma.
Macular Degeneration
Macular Degeneration: Science and Medicine in Practice provides a unique overview of current thinking in the pathogenesis, incidence and treatment of AMD. It includes, for the first time, a synthesis of the views of the world's leading scientists and practitioners regarding retinal biology, basic mechanisms, clinical and pathogenetic processes, and rational approaches to intervention.
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Lung biology and pathophysiology
The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.
Liver carcinogenesis : Methods and protocols
Discusses the latest advancements in modern methodologies used to study liver carcinogenesis. The first half of this book describes pertinent preclinical models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), established either through orthotopic induction of ectopic implantation. The second half of this book covers a diverse array of techniques applied to characterize the biochemical and cellular composition of hepatic malignancies that operate at the single-cell and histological levels. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Listeria Monocytogenes : Pathogenesis and Host Response
This comprehensive volume, written by experts in the field, includes concise and timely reviews of Listeria monocytogenes, one of the most intensively studied bacterial pathogens. Listeria monocytogenes is the cause of listeriosis, a potentially fatal disease that arises from the consumption of contaminated food. During the past two decades, studies of this organism have uncovered a wealth of information on its virulence factors, its genome organization, and its interactions with host cells and the immune system.
Legionella Pneumophila : Pathogenesis and Immunity
Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. The volume brings together all of the lastest research on this pathogen, the interest in which is rapidly growing.
Kindling 6
A broad array of themes concerned with research on epilepsy and kindling is covered in the book: Pathogenesis of kindling, including developmental patterns; electrophysiology; anatomy, morphology, and neural circuitry; genes, species, and strains; synaptic pharmacology and neurochemistry ; Behavioral consequences of kindling ; Drugs and interventions against kindling ; Clinical relevance of kindling for our understanding of epilepsy in patients
Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality, with at least one third of cases requiring hospitalization, exceeding the numbers admitted for myocardial infarction and stroke. Despite a broad armamentarium of antimicrobials available, it remains an important cause of death in industrialized countries. CAP is caused by a variety of pathogens with their order of importance dependent on the location and population studied. Despite the importance of CAP, reliable data and a recommended evidence-based therapy are lacking, and basic research must be improved. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered. The volume is of interest to researchers and clinicians in virology, epidemiology and biomedicine.
Cigarette Smoke and Oxidative Stress
From a public health point of view, there is little doubt that one of the most important preventable causes of disease worldwide is tobacco smoking. From a scientifc point of view, we found it of interest to make a comprehensive ov- view of what we presently know about oxidative stress and tobacco smoke, because sm- ing is presently the best-known common condition associated with oxidative stress, and it may serve as a model for others. To this end, we have asked distinguished researchers from the public and the private sectors to evaluate the present scientifc status in their particular area. Authors were selected purely because of their scientifc merits.
Chronic Viral and Inflammatory Cardiomyopathy
This publication constitutes the outcome of an ESRF meeting held together with the German Research Foundation. Clinical researchers, immunologists, virologists and molecular biologists provide the latest findings in their fields, advancing our understanding of what causes chronic viral and inflammatory cardiomyopathy, why it affects a subset of individuals while sparing the majority, how we can develop better therapies, and whether the disease can be prevented. Special emphasis is placed on the role of viruses in the aetiology and pathogenesis of cardiomyopathy.
Chronic Lymphocytic Leukemia
Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. developments of basic science into effective new approaches to the patient.
Chlamydia pneumoniae infection and disease : Infection and disease
This volume, part of the Infectious Agents and Pathogenesis series, is a complete portrait of C. pneumoniae and what is currently known about it
Chemokines and Viral Infection
This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
Cell Signaling in Vascular Inflammation
Although inflammatory disease of the vascular bed of the lung is a major cause of morbidity and mortality in both adult and pediatric age groups, the importance of vascular biology to its understanding, and in developing novel therapeutics, has been overlooked. In Cell Signaling in Vascular Inflammation, leading basic and clinical researchers review the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement.
Carcinoma della cervice uterina : Eziopatogenesi e profilassi = Carcinoma of the uterine cervix : Aetiopathogenesis and prophylaxis
The volume offers a synthetic and updated picture of a complex topic that includes the multifactorial etiopathogenesis of cervical cancer, the characteristics of the virus, the dynamics of HPV infections, the histological lesions of the cervix leading to cervical cancer. and the characteristics of the various surgical treatments, the current strategies for early diagnosis through the use of molecular assays currently on the market, up to the trials of the two vaccines recently registered also in Italy.
Cancer : Cell Structures, Carcinogens and Genomic Instability
Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related.
Calcium and Phosphate Metabolism Management in Chronic Renal Disease
Calcium and Phosphate Metabolism Management in Chronic Renal Diseases provides an overview of the state-of-the-art clinical and basic science aspects of abnormal calcium and phosphate metabolism and its management.
