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الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Online hate speech in the European Union : A discourse-analytic perspective
open access under a CC BY 4.0 license and reports on research carried out as part of the European Union co-funded C.O.N.T.A.C.T. project which targeted hate speech and hate crime across a number of EU member states. It showcases the bearing that discourse analytic research can have on our understanding of this phenomenon that is a growing global cause for concern.
Nuclear Law : The Global Debate
This open access book traces the journey of nuclear law: its origins, how it has developed, where it is now, and where it is headed. As a discipline, this highly specialized body of law makes it possible for us to benefit from the life-saving applications of nuclear science and technology, including diagnosing cancer as well as avoiding and mitigating the effects of climate change. This book seeks to give readers a glimpse into the future of nuclear law, science and technology. It intends to provoke thought and discussion about how we can maximize the benefits and minimize the risks inherent in nuclear science and technology. This compilation of essays presents a global view in discipline as well as in geography.
Norwegian Shipping in the 20th Century : Norway's Successful Navigation of the World's Most Global Industry
This open access book discusses how Norwegian shipping companies played a crucial role in global shipping markets in the 20th century, at times transporting more than ten per cent of world seaborne trade. Chapters explore how Norway managed to remain competitive, despite being a high labour-cost country in an industry with global competition. Among the features that are emphasised are market developments, business strategies and political decisions The Norwegian experience was shaped by the main breaking points in 20th century world history, such as the two world wars, and by long-term trends, such as globalization and liberalization. The shipping companies introduced technological and organizational innovations to build or maintain a competitive advantage in a rapidly changing world. The growing importance of offshore petroleum exploration in the North Sea from the 1970s was both a threat and an opportunity to the shipping companies. By adapting both business strategies and the political regime to the new circumstances, the Norwegian shipping sector managed to maintain a leading position internationally.
Nature-Based Solutions to Climate Change Adaptation in Urban Areas : Linkages between Science, Policy and Practice
This book is open access under a CC BY 4.0 license.This book brings together research findings and experiences from science, policy and practice to highlight and debate the importance of nature-based solutions to climate change adaptation in urban areas. Emphasis is given to the potential of nature-based approaches to create multiple-benefits for society
Musical Haptics
This Open Access book offers an original interdisciplinary overview of the role of haptic feedback in musical interaction. Divided into two parts, part I examines the tactile aspects of music performance and perception, discussing how they affect user experience and performance in terms of usability, functionality and perceived quality of musical instruments. Part II presents engineering, computational, and design approaches and guidelines that have been applied to render and exploit haptic feedback in digital musical interfaces.Musical Haptics introduces an emerging field that brings together engineering, human-computer interaction, applied psychology, musical aesthetics, and music performance.
Multi-dimensional Approaches Towards New Technology : Insights on Innovation, Patents and Competition
This open access edited book captures the complexities and conflicts arising at the interface of intellectual property rights (IPR) and competition law. To do so, it discusses four specific themes: (a) policies governing functioning of standard setting organizations (SSOs), transparency and incentivising future innovation; (b) issue of royalties for standard essential patents (SEPs) and related disputes; (c) due process principles, procedural fairness and best practices in competition law; and (d) coherence of patent policies and consonance with competition law to support innovation in new technologies.
Motivational profiles in TIMSS mathematics : Exploring student clusters across aountries and time
This open access book presents a person-centered exploration of student profiles, using variables related to motivation to do school mathematics derived from the IEA’s Trends in International Mathematics and Science Study (TIMSS) data. Statistical cluster analysis is used to identify groups of students with similar motivational profiles, across grades and over time, for multiple participating countries. In this book, a person-centered analysis of distinct and meaningful motivational profiles and their differences on sociodemographic variables and mathematics performance broadens understanding about the role that motivation characteristics play in learning and achievement in mathematics.
Methodological Investigations in Agent-Based Modelling : With Applications for the Social Sciences
Examines the methodological complications of using complexity science concepts within the social science domain. The opening chapters take the reader on a tour through the development of simulation methodologies in the fields of artificial life and population biology, then demonstrates the growing popularity and relevance of these methods in the social sciences. Following an in-depth analysis of the potential impact of these methods on social science and social theory, the text provides substantive examples of the application of agent-based models in the field of demography. This work offers a unique combination of applied simulation work and substantive, in-depth philosophical analysis, and as such has potential appeal for specialist social scientists, complex systems scientists, and philosophers of science interested in the methodology of simulation and the practice of interdisciplinary computing research.
Mathematics teacher education in the Andean region and Paraguay : A comparative analysis of issues and challenges
This Open Access book is an excellent synthesis of the initial and continuing preparation for Mathematics Teaching in Bolivia, Ecuador, Paraguay and Peru, from which comparative analyses can be made that show similarities and differences, and highlight various perspectives. This book brings to the international Educational Community an important collection of experiences and ideas in the Mathematics Education of four Latin-American countries in the developing Andean region and Paraguay. The dissemination of these results can promote the search for international collaborative actions in a wider scale.
Interferometry and Synthesis in Radio Astronomy
This book is open access under a CC BY-NC 4.0 license.The third edition of this indispensable book in radio interferometry provides extensive updates to the second edition, including results and technical advances from the past decade; discussion of arrays that now span the full range of the radio part of the electromagnetic spectrum observable from the ground, 10 MHz to 1 THz; an analysis of factors that affect array speed; and an expanded discussion of digital signal-processing techniques and of scintillation phenomena and the effects of atmospheric water vapor on image distortion, among many other topics.
IMPROVE - Innovative modelling approaches for production systems to raise validatable efficiency : Intelligent methods for the factory of the future
This open access work presents selected results from the European research and innovation project IMPROVE which yielded novel data-based solutions to enhance machine reliability and efficiency in the fields of simulation and optimization, condition monitoring, alarm management, and quality prediction.
Human Rights in Child Protection : Implications for Professional Practice and Policy
This open access book critically explores what child protection policy and professional practice would mean if practice was grounded in human rights standards. This book inspires a new direction in child protection research – one that critically assesses child protection policy and professional practice with regard to human rights in general, and the rights of the child in particular. Each chapter author seeks to approach the rights of the child from their own academic field of interest and through a comparative lens, making the research relevant across nation-state practices.
Hormones, metabolism and the benefits of exercise
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
High-Performance Modelling and Simulation for Big Data Applications: Selected Results of the COST Action IC1406 cHiPSet
This book is the final compendium of case studies emanated from “High-Performance Modelling and Simulation for Big Data Applications” (cHiPSet).cHiPSet has created a sustainable reference network linking applied research in High Performance Computing (HPC) and Modelling & Simulation to tangibly address Big Data challenges.cHiPSet has also endeavoured to use and exploit results through Open Science practices, i.e., open access publication, open access to data repositories, and open-source software development. A testament to this philosophy, this compendium is set to become a required reference for the fast-changing fields of HPC, Big Data, and Modelling & Simulation.
Higher Education in the Era of the Fourth Industrial Revolution
This collection examines how higher education responds to the demands of the automation economy and the fourth industrial revolution. Considering significant trends in how people are learning, coupled with the ways in which different higher education institutions and education stakeholders are implementing adaptations, it looks at new programs and technological advances that are changing how and why we teach and learn. The book addresses trends in liberal arts integration of STEM innovations, the changing role of libraries in the digital age, global trends in youth mobility, and the development of lifelong learning programs.
Forecasting and Assessing Risk of Individual Electricity Peaks
The overarching aim of this open access book is to present self-contained theory and algorithms for investigation and prediction of electric demand peaks. A cross-section of popular demand forecasting algorithms from statistics, machine learning and mathematics is presented, followed by extreme value theory techniques with examples.
Feminist and LGBTI+ activism across Russia, Scandinavia and Turkey : Transnationalizing spaces of resistance
What do struggles for women’s and LGBTI+ rights in Russia, Turkey and the Scandinavian countries have in common? And what can actors who struggle for rights and justice in these contexts learn from each other? Based on a multisited ethnography of feminist and LGBTI+ activisms across Russia, Turkey and the Scandinavian countries, this Open Access book explores transnational struggles on various levels, from the micro-scale of the everyday to large-scale, spectacular events. Drawing on ethnographic insights and encounters from various sites, this book conceptualizes resistance as situated in the grey zone between barely perceptible, even hidden or covert, forms of mundane activist practices and highly visible street protests, gathering large crowds. Taking the reader beyond the dichotomies of visible/invisible and public/private, this book advances new understandings of resistance, solidarity, and activism in transnationalizing feminist and queer struggles, illustrated by rich ethnographic case studies from Russia, Scandinavia and Turkey.
Exceptional Lifespans
How long can humans live? This open access book documents, verifies and brings to life the advance of the frontier of human survival. It carefully validates data on supercentenarians, aged 110+, and semi-supercentenarians, aged 105-109, stored in the International Database on Longevity (IDL).
Evaluating Information Retrieval and Access Tasks : NTCIR's Legacy of Research Impact
This open access book summarizes the first two decades of the NII Testbeds and Community for Information access Research (NTCIR). NTCIR is a series of evaluation forums run by a global team of researchers and hosted by the National Institute of Informatics (NII), Japan. The book is unique in that it discusses not just what was done at NTCIR, but also how it was done and the impact it has achieved. For example, in some chapters the reader sees the early seeds of what eventually grew to be the search engines that provide access to content on the World Wide Web, today’s smartphones that can tailor what they show to the needs of their owners, and the smart speakers that enrich our lives at home and on the move. We also get glimpses into how new search engines can be built for mathematical formulae, or for the digital record of a lived human life.
