Development and In-vitro Dissolution Test of Pilocarpine PVA : Hydrogel Lenses

Due to high water content of hydrogel (wetting) and due to extended drug release comparing to ophthalmic solution and higher transparency comparing to ophthalmic ointment, soft contact lenses were found to elongate contact time with the eye and use it for long time without causing hypoxia or needing multiple dosing per a day. The objective of the study was to design, fabricate, and investigate the effectiveness of PVA hydrogel with DMSO soft contact lens in releasing the model drug, pilocarpine.