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الصفحة 1
الصفحة 1
Management of Erectile Dysfunction in Clinical Practice
Management of Erectile Dysfunction in Clinical Practice is a concise and practical guide to erectile dysfunction (ED) and its management. The book covers normal function and dysfunction, assessment, treatment options and interventions. Since ED is a symptom, not a disease the underlying causes such as hypertension, coronary artery disease, diabetes, chronic renal impairment, chronic arthritis, chronic alcoholism, multiple sclerosis are looked at.
La riabilitazione dei disturbi cognitivi nella sclerosi multipla = The rehabilitation of cognitive disorders in multiple sclerosis
Multiple sclerosis is one of the most frequent causes of chronic disability in young adults. It mainly affects individuals between 20 and 50 years of age, with a peak of incidence around the age of 30. This disease is characterized by the presence of demyelinating lesions of an inflammatory nature disseminated in the central nervous system. The different localization of these lesions is at the basis of the variability of clinical symptoms which can be characterized by motor, sensory, neurovegetative and cognitive disorders. The latter concern about half of the patients affected by this pathology and have a significant impact on the personal, family and work situation of these patients.
Chemokine biology : Basic research and clinical application ; Vol.2 : Pathophysiology of chemokines
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Advances in multiple Sclerosis and Experimental Demyelinating Diseases
Challenging Charcot’s hypothesis that inflammatory response is the primary contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold look at the causes and possible treatments of MS.Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore viruses, toxins and genetic defects as possible culprits. They present novel methods to interrupt and reverse demyelination. This book examines the correlation between axonal loss and clinical deficits, including the implied role of the CD8+ T cell and perforin. It assesses proteases, specifically, kallikrein 6, which are strongly associated with active demyelination. By directing natural autoantibodies against oligodendrocytes that demonstrate remyelination in animal models, the authors envision clinical trials for remyelination enhancement.
